Missense3DLogo

Missense3D predicts the structural changes introduced by an amino acid substitution and is applicable to analyse both PDB coordinates and homology-predicted structures.

Please cite: Ittisoponpisan, S., Islam, S.A., Khanna, T., Alhuzimi, E., David, A. & Sternberg, M.J.E. (2019)
Can Predicted Protein 3D Structures Provide Reliable Insights into whether Missense Variants Are Disease Associated? J. Mol. Biol. 431, 2197-2212.
https://doi.org/10.1016/j.jmb.2019.04.009

Missense3DLogo

Missense3D predicts the structural changes introduced by an amino acid substitution and is applicable to analyse both PDB coordinates and homology-predicted structures.


Choose your input from:


or


Variant information

Please select a valid amino acid.
Please select a valid amino acid.
Example

#PDB #Chain #Residue No. #WildtypeAA #MutantAA
P06280 3hg3 B 52 Cys Arg
P00918 2fos A 107 His Tyr
*Each column is separated by a space.

Example

#PDB #Chain #Residue No. #WildtypeAA #MutantAA
3hg3 B 52 Cys Arg
2fos A 107 His Tyr
*Each column is separated by a space.

3hg3 B 52 Cys Arg 2fos A 107 His Tyr
P06280 3hg3 B 52 Cys Arg P00918 2fos A 107 His Tyr


Get your protein structure predicted

If the structure of the protein you wish to analyse is not available, you can get one using our in-house homology model predictor Phyre2.

Go to Phyre2 website

AlphaFold Models

You can now use AlphaFold models in Missense3D, just upload your AlphaFold model using the 'Position on 3D structure' mode. If you want to learn more about AlphaFold models please read our recent Perspective article in Journal of Molecular Biology available at https://doi.org/10.1016/j.jmb.2021.167336


Medical Disclaimer: Missense3D is intended for purely research purposes. It should not be used for medical or professional advice or any clinical decision making.

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