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Missense3D-PTM^db is a comprehensive resource which allows users to explore millions of variants, post-translational modifications (PTMs), and topology information, if any, for the collection of canonical proteins within the human proteome (~20,000). Users can visualize these features on a 3D AlphaFold model for their protein of interest by simply providing (1) a gene name or UniProt ID, (2) a position within the canonical UniProt protein sequence, and (3) the wild type residue at that position.

Preprint now available in bioRxiv
Missense3D-PTMdb an interactive web resource to explore and visualize genetic variants and post-translational modifications sites (PTMs) using AlphaFold 3D models
Haotian Zhao, Ryan Pye, Grace Walker, Wendy Tran, Olivia Simmonds, Ifigenia Tsitsa, Suhail Islam, Gordon Hanna, Alessia David
bioRxiv 2025.07.22.666170; doi: https://doi.org/10.1101/2025.07.22.666170

Click here for more information on datasets used within Missense3D-PTM and additional documentation.

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Find Protein Features

UniProt ID:

ORGene Name:

Residue Position:

Wild Type Residue:(Required just as a check)

Please select a valid amino acid.