search Missense3D-DB

Search Examples - UniProt ID: Q9BYF1 | Gene name: ACE2

Note: Currently Missense3D-DB hosts variants prediction based on what we consider the best representative 3D coordinates for the query protein (see Documentation for details). However, additional 3D coordinates representing the query protein in different conformational states or in complex with ligands or other proteins may be available.

Please use our Missense3D software if:
- your variant is currently not in the database, or
- you want to make predictions using different 3D coordinates

Database statistics: Number of variants = 3,960,015; Variant sources = Humsavar (49,480), ClinVar (82,880), dbSNP (including gnomAD) (3,865,525) mapped to PDB structures or Phyre models.

Missense3D-DB is free for academic and commercial users.

Medical Disclaimer: Missense3D is intended for purely research purposes. It should not be used for medical or professional advice or any clinical decision making.
If you use Missense3D-DB please cite:

1. Khanna, T., Hanna, G., Sternberg, M.J.E. & David, A. (2021) Missense3D-DB web catalogue: an atom-based analysis and repository of 4M human protein-coding genetic variants. Human Genetics, 140(5), 805-812. DOI: 10.1007/s00439-020-02246-z

2. Ittisoponpisan, S., Islam, S.A., Khanna, T., Alhuzimi, E., David, A. & Sternberg, M.J.E. (2019) Can Predicted Protein 3D Structures Provide Reliable Insights into whether Missense Variants Are Disease Associated? J. Mol. Biol. 431, 2197-2212. DOI: 10.1016/j.jmb.2019.04.009

version 1.5.1 11/05/21