Missense3D-DB results

(structural effect of missense variants)

Note: In this version of the database, the structural analysis is based on the impact of a variant on the protein tertiary structure. The missense variant may disrupt additional features (e.g. protein-protein interactions or functional sites) that we are currently not capturing.

UniProt ID: P48643     Gene name: CCT5     pLI score: 1.0 tooltip info, click for explanation of pLI score     RVIS score: -0.61 (24.0 %) tooltip info, click for explanation of RVIS scores

tooltip info, click on the Download Report checkbox to display the column which supports the download of a custom report in the results table    tooltip info, click on the UniProt Position checkbox to display the uniprot position column in the results table    tooltip info, click on the PDB/Model Position checkbox to display the PDB or Model position column in the results table    tooltip info, click on the Residue Wildtype checkbox to display the wildtype residue column in the results table    tooltip info, click on the Residue Mutant checkbox to display the mutant residue column in the results table    tooltip info, click on the Structure checkbox to display the PDB/structure id column in the results table    tooltip info, click on the Structure Type checkbox to display the PDB/Phyre model column in the results table    tooltip info, click on the Missense3D Prediction checkbox to display the Missense3D Prediction column in the results table    tooltip info, click on the Structural damage predicted checkbox to display the column detailing whether structural damage is predicted in the results table    tooltip info, click on the Humsavar annotation checkbox to display the Humsavar annotation column in the results table    tooltip info, click on the ClinVar annotation checkbox to display the ClinVar annotation column in the results table    tooltip info, click on the MAF score checkbox to display the MAF score column in the results table    tooltip info, click on the dbSNP checkbox to display the dbSNP id column in the results table    tooltip info, click on the Ensemble ID checkbox to display the Ensemble ID column in the results table    tooltip info, click on the SIFT prediction(score) checkbox to display the SIFT prediction and score column in the results table    tooltip info, click on the PolyPhen-2 prediction(score) checkbox to display the PolyPhen-2 prediction and score column in the results table    tooltip info, click on the Interface(source RCSB) checkbox to display the Interface column in the results table    tooltip info, click on the Pfam domain checkbox to display the Pfam domain id column in the results table    tooltip info, click on the Location (GRCh37) checkbox to display the column containing the GRCh37 Chromosome location in the results table    tooltip info, click on the Location (GRCh38) checkbox to display the column containing the GRCh38 Chromosome location in the results table    tooltip info, click on the CCR percentile checkbox to display the conserved coding region percentile column in the results table    tooltip info, click on the GERP score checkbox to display the GERP score column in the results table

If your variant is not present in the table below click here to use our missense3d website to analyse it using your own 3D structural model.

Download Report Uniprot Position PDB/Model Position Residue Wildtype Residue Mutant Structure Structure Type Missense3D Prediction Structural damage predicted Humsavar Annotation ClinVar Annotation MAF score dbSNP Ensemble ID SIFT prediction(score) PolyPhen-2 prediction(score) Interface(source RCSB) Pfam domain Location (GRCh37) Location (GRCh38) CCR percentile GERP score
link to download the report for this variant 147 147 HIS ARG 5uyx_D PDB Neutral none predicted Pathogenic Not_provided - - - tolerated(0.51) benign(0.007) - Cpn60_TCP1 - - - -
link to download the report for this variant 146 146 GLU VAL 5uyx_D PDB Neutral none predicted Benign Benign - - - deleterious(0.03) benign(0.267) - Cpn60_TCP1 - - - -
link to download the report for this variant 29 29 MET THR 5uyz_D PDB Neutral none predicted - VUS 4.068e-06 rs141133834 ENST00000280326 tolerated(0.58) benign(0.03) - - 5:10250538 5:10250426 0 5.45
link to download the report for this variant 89 89 LYS ASN 5uyx_D PDB Neutral none predicted - VUS - - - deleterious(0) possibly_damaging(0.862) Yes Cpn60_TCP1 - - - -
link to download the report for this variant 163 163 GLU LYS 5uyx_D PDB Damaging Buried H-bond breakage - VUS 3.257e-05 rs552008894 ENST00000280326 tolerated(0.06) benign(0.127) - Cpn60_TCP1 5:10256222 5:10256110 6 5.61
link to download the report for this variant 226 226 LYS ARG 5uyx_D PDB Neutral none predicted - VUS - rs768757632 ENST00000280326 tolerated(0.19) benign(0.06) - Cpn60_TCP1 5:10258369 5:10258257 28 5.59
link to download the report for this variant 293 293 LYS ILE 5uyx_D PDB Neutral none predicted - VUS - - - deleterious(0) probably_damaging(0.976) - Cpn60_TCP1 - - - -
link to download the report for this variant 299 299 LEU VAL 5uyx_D PDB Damaging Cavity altered - VUS 4.061e-06 rs141509761 ENST00000280326 tolerated(0.49) possibly_damaging(0.536) - Cpn60_TCP1 5:10260925 5:10260813 86 5.79
link to download the report for this variant 351 351 GLU LYS 5uyx_D PDB Neutral none predicted - VUS 4.874e-05 rs140095139 ENST00000280326 tolerated(0.07) possibly_damaging(0.48) Yes Cpn60_TCP1 5:10261729 5:10261617 76 4.5
link to download the report for this variant 357 357 GLY ASP 5uyx_D PDB Neutral none predicted - VUS 0.0006173 rs143444882 ENST00000280326 tolerated(0.07) probably_damaging(1) - Cpn60_TCP1 5:10261748 5:10261636 1 5.39
link to download the report for this variant 362 362 ILE MET 5uyx_D PDB Neutral none predicted - Benign 0.006071 rs141675330 ENST00000280326 tolerated(0.27) benign(0.038) - Cpn60_TCP1 5:10261764 5:10261652 1 3.59
link to download the report for this variant 378 378 LYS GLU 4V94_E MODEL Neutral none predicted - VUS 3.655e-05 rs773314762 ENST00000280326 tolerated(0.68) benign(0.005) - Cpn60_TCP1 5:10261810 5:10261698 80 4.18
link to download the report for this variant 395 395 ILE VAL 5uyx_C PDB Neutral none predicted - VUS - - - tolerated(1) benign(0.024) - Cpn60_TCP1 - - - -
link to download the report for this variant 439 439 LYS THR 5uyx_D PDB Neutral none predicted - VUS 1.625e-05 rs768671276 ENST00000280326 tolerated(0.12) benign(0.349) - Cpn60_TCP1 5:10262729 5:10262617 15 5.09
link to download the report for this variant 442 442 THR ALA 5uyx_D PDB Neutral none predicted - VUS - - - deleterious(0.01) benign(0.026) Yes Cpn60_TCP1 - - - -
link to download the report for this variant 446 446 TYR HIS 5uyx_D PDB Neutral none predicted - VUS - - - deleterious(0.02) probably_damaging(1) Yes Cpn60_TCP1 - - - -
link to download the report for this variant 449 449 ARG LYS 5uyx_D PDB Neutral none predicted - VUS 8.123e-06 rs762423535 ENST00000280326 tolerated(0.09) possibly_damaging(0.876) Yes Cpn60_TCP1 5:10263274 5:10263162 6 5.63
link to download the report for this variant 492 492 ASP ASN 5uyx_D PDB Neutral none predicted - VUS 4.488e-05 rs749250007 ENST00000280326 deleterious(0) probably_damaging(0.998) - Cpn60_TCP1 5:10263402 5:10263290 45 5.63
link to download the report for this variant 492 492 ASP HIS 5uyx_D PDB Neutral none predicted - VUS 4.488e-05 rs749250007 ENST00000280326 deleterious(0) probably_damaging(0.998) - Cpn60_TCP1 5:10263402 5:10263290 45 5.63
link to download the report for this variant 14 14 ARG LEU 4V94_E MODEL Neutral none predicted - - - rs1273941214 ENST00000280326 deleterious(0) benign(0.012) - - 5:10250493 5:10250381 92 4.58
link to download the report for this variant 21 21 ASP ASN 4V94_E MODEL Neutral none predicted - - - rs1213195325 ENST00000280326 tolerated(0.05) benign(0.017) - - 5:10250513 5:10250401 92 5.45
link to download the report for this variant 22 22 GLN GLU 4V94_E MODEL Neutral none predicted - - 8.129e-06 rs545528591 ENST00000280326 tolerated(0.08) possibly_damaging(0.481) - - 5:10250516 5:10250404 0 5.45
link to download the report for this variant 22 22 GLN ARG 4V94_E MODEL Neutral none predicted - - 4.065e-06 rs1423621557 ENST00000280326 deleterious(0) possibly_damaging(0.765) - - 5:10250517 5:10250405 1 5.45
link to download the report for this variant 23 23 ASP HIS 4V94_E MODEL Neutral none predicted - - 4.064e-06 rs768773985 ENST00000280326 deleterious(0.05) benign(0.006) - - 5:10250519 5:10250407 6 5.45
link to download the report for this variant 24 24 ARG SER 4V94_E MODEL Neutral none predicted - - 8.13e-06 rs747916999 ENST00000280326 tolerated(0.18) benign(0) - - 5:10250522 5:10250410 10 5.45
link to download the report for this variant 25 25 LYS ARG 4V94_E MODEL Neutral none predicted - - 4.065e-06 rs769677185 ENST00000280326 tolerated(0.12) benign(0.003) - - 5:10250526 5:10250414 1 5.45
link to download the report for this variant 26 26 SER THR 4V94_E MODEL Neutral none predicted - - 8.132e-06 rs772848951 ENST00000280326 tolerated(0.64) benign(0) - - 5:10250528 5:10250416 3 2.95
link to download the report for this variant 28 28 LEU PHE 4V94_E MODEL Neutral none predicted - - 1.22e-05 rs1297478583 ENST00000280326 tolerated(0.06) possibly_damaging(0.611) - - 5:10250534 5:10250422 6 5.45
link to download the report for this variant 29 29 MET LYS 5uyz_D PDB Neutral none predicted - - 4.068e-06 rs141133834 ENST00000280326 tolerated(0.58) benign(0.03) - - 5:10250538 5:10250426 0 5.45
link to download the report for this variant 29 29 MET ARG 5uyz_D PDB Neutral none predicted - - 4.068e-06 rs141133834 ENST00000280326 tolerated(0.58) benign(0.03) - - 5:10250538 5:10250426 0 5.45
link to download the report for this variant 29 29 MET VAL 5uyz_D PDB Neutral none predicted - - 4.067e-06 rs773861292 ENST00000280326 tolerated(0.43) benign(0.003) - - 5:10250537 5:10250425 0 5.45
link to download the report for this variant 29 29 MET LEU 5uyz_D PDB Neutral none predicted - - 4.067e-06 rs773861292 ENST00000280326 tolerated(0.43) benign(0.003) - - 5:10250537 5:10250425 0 5.45
link to download the report for this variant 29 29 MET ILE 5uyz_D PDB Neutral none predicted - - 4.069e-06 rs1355138785 ENST00000280326 tolerated(0.36) benign(0) - - 5:10250539 5:10250427 1 5.45
link to download the report for this variant 30 30 GLY GLU 5uyz_D PDB Neutral none predicted - - 4.069e-06 rs767111523 ENST00000280326 deleterious(0.04) possibly_damaging(0.907) - - 5:10250541 5:10250429 6 5.45
link to download the report for this variant 31 31 LEU PRO 5uyx_D PDB Neutral none predicted - - 1.221e-05 rs752348970 ENST00000280326 tolerated(0.06) benign(0.248) Yes - 5:10250544 5:10250432 10 5.45
link to download the report for this variant 32 32 GLU ASP 5uyx_D PDB Neutral none predicted - - 4.072e-06 rs1359521662 ENST00000280326 tolerated(0.34) benign(0.001) - - 5:10250548 5:10250436 78 0.61
link to download the report for this variant 36 36 SER PHE 5uyx_D PDB Neutral none predicted - - - rs1333902630 ENST00000280326 deleterious(0) possibly_damaging(0.836) - - 5:10254258 5:10254146 78 5.26
link to download the report for this variant 38 38 ILE VAL 5uyx_D PDB Neutral none predicted - - - rs1191228356 ENST00000280326 deleterious(0.04) possibly_damaging(0.873) - - 5:10254263 5:10254151 78 5.26
link to download the report for this variant 39 39 MET ILE 5uyx_D PDB Neutral none predicted - - 3.656e-05 rs142638550 ENST00000280326 tolerated(0.1) benign(0.01) - - 5:10254268 5:10254156 15 5.26
link to download the report for this variant 39 39 MET THR 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs1445582465 ENST00000280326 tolerated(0.14) benign(0.001) - - 5:10254267 5:10254155 0 5.26
link to download the report for this variant 41 41 ALA GLY 5uyx_D PDB Neutral none predicted - - 4.063e-06 rs1337016126 ENST00000280326 tolerated(0.07) benign(0.027) - - 5:10254273 5:10254161 71 5.26
link to download the report for this variant 43 43 ALA ASP 5uyx_D PDB Neutral none predicted - - - - - tolerated(0.09) benign(0.016) - - - - - -
link to download the report for this variant 47 47 THR ALA 5uyx_D PDB Neutral none predicted - - 6.5e-05 rs770668105 ENST00000280326 tolerated(0.06) benign(0.168) Yes Cpn60_TCP1 5:10254290 5:10254178 6 5.26
link to download the report for this variant 48 48 MET LEU 5uyx_D PDB Neutral none predicted - - - - - tolerated(1) benign(0) - Cpn60_TCP1 - - - -
link to download the report for this variant 48 48 MET ILE 5uyx_D PDB Neutral none predicted - - - rs1471919727 ENST00000280326 tolerated(0.2) benign(0) - Cpn60_TCP1 5:10254295 5:10254183 10 5.26
link to download the report for this variant 48 48 MET VAL 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs778660679 ENST00000280326 tolerated(0.2) benign(0) - Cpn60_TCP1 5:10254293 5:10254181 10 5.26
link to download the report for this variant 49 49 ARG THR 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs1323483213 ENST00000280326 deleterious(0.02) possibly_damaging(0.744) - Cpn60_TCP1 5:10254297 5:10254185 62 4.37
link to download the report for this variant 54 54 PRO THR 5uyx_D PDB Damaging Cavity altered - - 4.062e-06 rs745860397 ENST00000280326 deleterious(0) probably_damaging(0.981) Yes Cpn60_TCP1 5:10254311 5:10254199 6 5.26
link to download the report for this variant 55 55 ASN HIS 5uyx_D PDB Neutral none predicted - - 8.125e-06 rs771901324 ENST00000280326 deleterious(0.04) possibly_damaging(0.811) Yes Cpn60_TCP1 5:10254314 5:10254202 22 5.26
link to download the report for this variant 57 57 LEU PHE 5uyx_D PDB Neutral none predicted - - 1.22e-05 rs768096968 ENST00000280326 deleterious(0.05) probably_damaging(0.97) Yes Cpn60_TCP1 5:10254788 5:10254676 54 3.83
link to download the report for this variant 57 57 LEU ILE 5uyx_D PDB Neutral none predicted - - 1.22e-05 rs768096968 ENST00000280326 deleterious(0.05) probably_damaging(0.97) Yes Cpn60_TCP1 5:10254788 5:10254676 54 3.83
link to download the report for this variant 61 61 MET VAL 5uyx_D PDB Neutral none predicted - - 4.064e-06 rs1381959516 ENST00000280326 deleterious(0.03) possibly_damaging(0.588) Yes Cpn60_TCP1 5:10254800 5:10254688 22 4.43
link to download the report for this variant 63 63 ASP TYR 5uyx_D PDB Neutral none predicted - - 4.064e-06 rs764202392 ENST00000280326 deleterious(0) possibly_damaging(0.876) Yes Cpn60_TCP1 5:10254806 5:10254694 65 5.64
link to download the report for this variant 68 68 VAL MET 5uyx_D PDB Neutral none predicted - - 4.063e-06 rs1224885104 ENST00000280326 deleterious(0.04) probably_damaging(0.954) Yes Cpn60_TCP1 5:10254821 5:10254709 45 5.64
link to download the report for this variant 71 71 THR SER 5uyx_D PDB Neutral none predicted - - 4.063e-06 rs779051065 ENST00000280326 tolerated(0.07) probably_damaging(0.999) - Cpn60_TCP1 5:10254831 5:10254719 28 5.64
link to download the report for this variant 72 72 ASN SER 5uyx_D PDB Neutral none predicted - - - rs986387458 ENST00000280326 deleterious(0) probably_damaging(0.999) Yes Cpn60_TCP1 5:10254834 5:10254722 28 5.64
link to download the report for this variant 73 73 ASP GLU 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs750238294 ENST00000280326 deleterious(0) probably_damaging(1) - Cpn60_TCP1 5:10254838 5:10254726 1 -5.83
link to download the report for this variant 74 74 GLY ALA 5uyx_D PDB Damaging Buried Gly replaced - - 4.062e-06 rs1184491874 ENST00000280326 deleterious(0) probably_damaging(1) - Cpn60_TCP1 5:10254840 5:10254728 71 5.64
link to download the report for this variant 75 75 ALA THR 5uyx_D PDB Neutral none predicted - - - - - deleterious(0) probably_damaging(0.91) - Cpn60_TCP1 - - - -
link to download the report for this variant 76 76 THR ILE 5uyx_D PDB Neutral none predicted - - - - - deleterious(0.01) probably_damaging(1) - Cpn60_TCP1 - - - -
link to download the report for this variant 80 80 MET LEU 5uyx_D PDB Neutral none predicted - - 1.218e-05 rs779876496 ENST00000280326 tolerated(0.19) benign(0.001) Yes Cpn60_TCP1 5:10254857 5:10254745 10 4.43
link to download the report for this variant 80 80 MET VAL 5uyx_D PDB Neutral none predicted - - 1.218e-05 rs779876496 ENST00000280326 tolerated(0.19) benign(0.001) Yes Cpn60_TCP1 5:10254857 5:10254745 10 4.43
link to download the report for this variant 81 81 MET THR 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs754960953 ENST00000280326 deleterious(0) probably_damaging(0.989) Yes Cpn60_TCP1 5:10254861 5:10254749 49 5.64
link to download the report for this variant 85 85 HIS ASP 5uyx_D PDB Neutral none predicted - - 8.123e-06 rs780904848 ENST00000280326 deleterious(0.03) possibly_damaging(0.876) - Cpn60_TCP1 5:10254872 5:10254760 58 5.64
link to download the report for this variant 86 86 GLN HIS 5uyx_D PDB Neutral none predicted - - - rs1338375786 ENST00000280326 tolerated(0.18) benign(0.022) Yes Cpn60_TCP1 5:10254877 5:10254765 58 3.8
link to download the report for this variant 89 89 LYS GLU 5uyx_D PDB Neutral none predicted - - - rs201780415 ENST00000280326 deleterious(0) benign(0.249) Yes Cpn60_TCP1 5:10254884 5:10254772 0 5.64
link to download the report for this variant 89 89 LYS ARG 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs747601270 ENST00000280326 tolerated(0.15) benign(0.134) Yes Cpn60_TCP1 5:10254885 5:10254773 80 5.64
link to download the report for this variant 96 96 LYS ASN 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs772697210 ENST00000280326 deleterious(0.01) benign(0.109) Yes Cpn60_TCP1 5:10254907 5:10254795 98 -4.21
link to download the report for this variant 96 96 LYS ARG 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs1287422367 ENST00000280326 tolerated(0.17) benign(0.109) Yes Cpn60_TCP1 5:10254906 5:10254794 0 5.64
link to download the report for this variant 113 113 ALA THR 5uyx_D PDB Neutral none predicted - - - - - tolerated(0.05) probably_damaging(0.988) - Cpn60_TCP1 - - - -
link to download the report for this variant 116 116 LEU SER 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs747317758 ENST00000280326 deleterious(0) probably_damaging(1) - Cpn60_TCP1 5:10256082 5:10255970 39 5.61
link to download the report for this variant 119 119 GLU VAL 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs1479352026 ENST00000280326 deleterious(0) benign(0.405) Yes Cpn60_TCP1 5:10256091 5:10255979 0 5.61
link to download the report for this variant 119 119 GLU ASP 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs769157481 ENST00000280326 deleterious(0) benign(0.142) Yes Cpn60_TCP1 5:10256092 5:10255980 0 -1.42
link to download the report for this variant 120 120 ALA VAL 5uyx_D PDB Neutral none predicted - - - - - deleterious(0) probably_damaging(1) - Cpn60_TCP1 - - - -
link to download the report for this variant 121 121 GLU LYS 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs1473208692 ENST00000280326 tolerated(0.25) possibly_damaging(0.734) - Cpn60_TCP1 5:10256096 5:10255984 39 5.61
link to download the report for this variant 124 124 LEU VAL 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs765272975 ENST00000280326 deleterious(0.02) possibly_damaging(0.612) - Cpn60_TCP1 5:10256105 5:10255993 28 3.81
link to download the report for this variant 126 126 ARG GLN 5uyx_D PDB Neutral none predicted - - 8.123e-06 rs369788570 ENST00000280326 tolerated(0.13) benign(0.177) Yes Cpn60_TCP1 5:10256112 5:10256000 15 5.61
link to download the report for this variant 128 128 ILE VAL 5uyx_D PDB Neutral none predicted - - 3.249e-05 rs773337607 ENST00000280326 tolerated(0.08) benign(0.06) - Cpn60_TCP1 5:10256117 5:10256005 39 5.61
link to download the report for this variant 131 131 ILE VAL 5uyx_D PDB Neutral none predicted - - 8.122e-06 rs1440050099 ENST00000280326 tolerated(0.14) benign(0.074) Yes Cpn60_TCP1 5:10256126 5:10256014 10 5.61
link to download the report for this variant 132 132 ARG LYS 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs1299999750 ENST00000280326 tolerated(0.38) benign(0.173) Yes Cpn60_TCP1 5:10256130 5:10256018 15 5.61
link to download the report for this variant 133 133 ILE MET 5uyx_D PDB Neutral none predicted - - - rs1367000697 ENST00000280326 deleterious(0) probably_damaging(0.983) - Cpn60_TCP1 5:10256134 5:10256022 0 -8.19
link to download the report for this variant 134 134 ALA THR 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs374488155 ENST00000280326 deleterious(0.03) benign(0.309) - Cpn60_TCP1 5:10256135 5:10256023 6 5.61
link to download the report for this variant 135 135 ASP ASN 5uyx_D PDB Neutral none predicted - - 8.123e-06 rs751401579 ENST00000280326 tolerated(0.14) probably_damaging(1) Yes Cpn60_TCP1 5:10256138 5:10256026 1 5.61
link to download the report for this variant 137 137 TYR CYS 5uyx_D PDB Neutral none predicted - - - rs1327400996 ENST00000280326 deleterious(0) probably_damaging(0.976) - Cpn60_TCP1 5:10256145 5:10256033 0 5.61
link to download the report for this variant 139 139 GLN ARG 5uyx_D PDB Neutral none predicted - - - rs923026554 ENST00000280326 tolerated(0.55) possibly_damaging(0.449) Yes Cpn60_TCP1 5:10256151 5:10256039 49 5.61
link to download the report for this variant 139 139 GLN HIS 5uyx_D PDB Neutral none predicted - - - rs1342340114 ENST00000280326 tolerated(0.21) possibly_damaging(0.852) Yes Cpn60_TCP1 5:10256152 5:10256040 49 3.81
link to download the report for this variant 142 142 ARG CYS 5uyx_D PDB Neutral none predicted - - 7.717e-05 rs572671693 ENST00000280326 tolerated(0.06) benign(0.013) - Cpn60_TCP1 5:10256159 5:10256047 0 5.61
link to download the report for this variant 142 142 ARG HIS 5uyx_D PDB Neutral none predicted - - 2.437e-05 rs200433052 ENST00000280326 tolerated(0.07) benign(0.005) - Cpn60_TCP1 5:10256160 5:10256048 1 5.61
link to download the report for this variant 143 143 VAL ILE 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs777219709 ENST00000280326 tolerated(0.23) benign(0.003) - Cpn60_TCP1 5:10256162 5:10256050 22 4.46
link to download the report for this variant 143 143 VAL PHE 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs777219709 ENST00000280326 tolerated(0.23) benign(0.003) - Cpn60_TCP1 5:10256162 5:10256050 22 4.46
link to download the report for this variant 145 145 ILE LEU 5uyx_D PDB Neutral none predicted - - 8.124e-06 rs756876432 ENST00000280326 tolerated(1) benign(0.001) - Cpn60_TCP1 5:10256168 5:10256056 0 4.44
link to download the report for this variant 145 145 ILE VAL 5uyx_D PDB Neutral none predicted - - 8.124e-06 rs756876432 ENST00000280326 tolerated(1) benign(0.001) - Cpn60_TCP1 5:10256168 5:10256056 0 4.44
link to download the report for this variant 145 145 ILE THR 5uyx_D PDB Neutral none predicted - - 8.124e-06 rs747407479 ENST00000280326 tolerated(0.1) benign(0.005) - Cpn60_TCP1 5:10256169 5:10256057 1 5.61
link to download the report for this variant 146 146 GLU GLN 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs768960830 ENST00000280326 tolerated(0.29) benign(0.024) - Cpn60_TCP1 5:10256171 5:10256059 0 4.72
link to download the report for this variant 146 146 GLU GLY 5uyx_D PDB Neutral none predicted - - 0.02313 rs11557652 ENST00000280326 tolerated(0.05) benign(0.219) - Cpn60_TCP1 5:10256172 5:10256060 6 5.61
link to download the report for this variant 147 147 HIS GLN 5uyx_D PDB Neutral none predicted - - 3.25e-05 rs770321570 ENST00000280326 tolerated(0.11) benign(0.009) - Cpn60_TCP1 5:10256176 5:10256064 28 3.5
link to download the report for this variant 148 148 LEU VAL 5uyx_D PDB Neutral none predicted - - - rs763021273 ENST00000280326 deleterious(0.01) probably_damaging(0.939) - Cpn60_TCP1 5:10256177 5:10256065 28 4.55
link to download the report for this variant 149 149 ASP ASN 5uyx_D PDB Neutral none predicted - - 0.0 rs1408430674 ENST00000280326 tolerated(0.09) benign(0.139) - Cpn60_TCP1 5:10256180 5:10256068 28 5.61
link to download the report for this variant 150 150 LYS GLU 5uyx_D PDB Neutral none predicted - - 8.125e-06 rs771086015 ENST00000280326 tolerated(0.57) benign(0.001) - Cpn60_TCP1 5:10256183 5:10256071 6 0.0
link to download the report for this variant 150 150 LYS ARG 5uyx_D PDB Neutral none predicted - - - - - tolerated(0.29) benign(0.007) - Cpn60_TCP1 - - - -
link to download the report for this variant 151 151 ILE PHE 5uyx_D PDB Damaging Buried / exposed switch - - - - - deleterious(0) probably_damaging(0.973) - Cpn60_TCP1 - - - -
link to download the report for this variant 151 151 ILE LEU 5uyx_D PDB Neutral none predicted - - 2.031e-05 rs202190887 ENST00000280326 tolerated(0.1) benign(0.173) - Cpn60_TCP1 5:10256186 5:10256074 22 5.61
link to download the report for this variant 151 151 ILE VAL 5uyx_D PDB Neutral none predicted - - 2.031e-05 rs202190887 ENST00000280326 tolerated(0.1) benign(0.173) - Cpn60_TCP1 5:10256186 5:10256074 22 5.61
link to download the report for this variant 153 153 ASP TYR 5uyx_D PDB Neutral none predicted - - 4.064e-06 rs563305570 ENST00000280326 tolerated(0.08) possibly_damaging(0.732) - Cpn60_TCP1 5:10256192 5:10256080 22 5.61
link to download the report for this variant 153 153 ASP ASN 5uyx_D PDB Neutral none predicted - - 4.064e-06 rs563305570 ENST00000280326 tolerated(0.08) possibly_damaging(0.732) - Cpn60_TCP1 5:10256192 5:10256080 22 5.61
link to download the report for this variant 154 154 SER GLY 5uyx_D PDB Neutral none predicted - - - rs752539971 ENST00000280326 tolerated(0.33) benign(0.102) - Cpn60_TCP1 5:10256195 5:10256083 22 3.11
link to download the report for this variant 155 155 VAL ALA 5uyx_D PDB Neutral none predicted - - - rs201103056 ENST00000280326 deleterious(0.04) benign(0.04) - Cpn60_TCP1 5:10256199 5:10256087 10 5.61
link to download the report for this variant 155 155 VAL ILE 5uyx_D PDB Neutral none predicted - - 2.033e-05 rs760589901 ENST00000280326 tolerated(0.96) benign(0) - Cpn60_TCP1 5:10256198 5:10256086 10 3.65
link to download the report for this variant 156 156 LEU PRO 5uyx_D PDB Neutral none predicted - - 4.065e-06 rs764037204 ENST00000280326 tolerated(0.42) benign(0) - Cpn60_TCP1 5:10256202 5:10256090 1 3.26
link to download the report for this variant 157 157 VAL ILE 5uyx_D PDB Neutral none predicted - - 5.285e-05 rs753294597 ENST00000280326 tolerated(0.94) benign(0.03) - Cpn60_TCP1 5:10256204 5:10256092 6 5.61
link to download the report for this variant 157 157 VAL PHE 5uyx_D PDB Neutral none predicted - - 5.285e-05 rs753294597 ENST00000280326 tolerated(0.94) benign(0.03) - Cpn60_TCP1 5:10256204 5:10256092 6 5.61
link to download the report for this variant 158 158 ASP ASN 5uyx_D PDB Neutral none predicted - - 8.134e-06 rs1336981943 ENST00000280326 tolerated(0.3) benign(0.01) - Cpn60_TCP1 5:10256207 5:10256095 0 5.61
link to download the report for this variant 158 158 ASP GLY 5uyx_D PDB Neutral none predicted - - 4.067e-06 rs1215951935 ENST00000280326 tolerated(0.11) benign(0.006) - Cpn60_TCP1 5:10256208 5:10256096 1 5.61
link to download the report for this variant 159 159 ILE LEU 5uyx_D PDB Neutral none predicted - - 1.22e-05 rs759349493 ENST00000280326 tolerated(0.85) benign(0) - Cpn60_TCP1 5:10256210 5:10256098 0 -2.87
link to download the report for this variant 159 159 ILE LYS 5uyx_D PDB Neutral none predicted - - 0.0004962 rs200462817 ENST00000280326 tolerated(0.94) benign(0) - Cpn60_TCP1 5:10256211 5:10256099 33 -5.37
link to download the report for this variant 161 161 ASP ASN 5uyx_D PDB Neutral none predicted - - - rs1407512090 ENST00000280326 tolerated(0.87) benign(0.001) - Cpn60_TCP1 5:10256216 5:10256104 33 -2.16
link to download the report for this variant 162 162 THR SER 5uyx_D PDB Neutral none predicted - - 4.069e-06 rs748484897 ENST00000280326 tolerated(0.69) benign(0.01) - Cpn60_TCP1 5:10256219 5:10256107 6 3.14
link to download the report for this variant 162 162 THR ALA 5uyx_D PDB Neutral none predicted - - 4.069e-06 rs748484897 ENST00000280326 tolerated(0.69) benign(0.01) - Cpn60_TCP1 5:10256219 5:10256107 6 3.14
link to download the report for this variant 164 164 PRO SER 5uyx_D PDB Neutral none predicted - - 4.072e-06 rs1391060196 ENST00000280326 tolerated(0.5) benign(0.021) - Cpn60_TCP1 5:10256225 5:10256113 0 4.74
link to download the report for this variant 164 164 PRO LEU 5uyx_D PDB Neutral none predicted - - 4.072e-06 rs771088141 ENST00000280326 tolerated(0.71) benign(0.012) - Cpn60_TCP1 5:10256226 5:10256114 1 5.61
link to download the report for this variant 164 164 PRO HIS 5uyx_D PDB Neutral none predicted - - 4.072e-06 rs771088141 ENST00000280326 tolerated(0.71) benign(0.012) - Cpn60_TCP1 5:10256226 5:10256114 1 5.61
link to download the report for this variant 165 165 LEU MET 5uyx_D PDB Neutral none predicted - - 4.073e-06 rs535045917 ENST00000280326 tolerated(0.14) probably_damaging(0.988) - Cpn60_TCP1 5:10256228 5:10256116 6 5.61
link to download the report for this variant 166 166 ILE VAL 5uyx_D PDB Neutral none predicted - - 4.074e-06 rs1367302402 ENST00000280326 tolerated(0.61) benign(0.047) - Cpn60_TCP1 5:10256231 5:10256119 6 4.46
link to download the report for this variant 167 167 GLN GLU 5uyx_D PDB Neutral none predicted - - 4.075e-06 rs199552031 ENST00000280326 tolerated(0.23) benign(0.001) - Cpn60_TCP1 5:10256234 5:10256122 39 5.61
link to download the report for this variant 170 170 LYS GLU 5uyx_C PDB Neutral none predicted - - 8.163e-06 rs775442316 ENST00000280326 tolerated(0.28) benign(0.102) - Cpn60_TCP1 5:10256243 5:10256131 47 5.61
link to download the report for this variant 170 170 LYS GLN 5uyx_C PDB Neutral none predicted - - 8.163e-06 rs775442316 ENST00000280326 tolerated(0.28) benign(0.102) - Cpn60_TCP1 5:10256243 5:10256131 47 5.61
link to download the report for this variant 174 174 GLY SER 4V94_E MODEL Neutral none predicted - - 4.096e-06 rs763970749 ENST00000280326 tolerated(0.28) possibly_damaging(0.58) - Cpn60_TCP1 5:10256255 5:10256143 86 5.61
link to download the report for this variant 174 174 GLY ASP 4V94_E MODEL Neutral none predicted - - - rs1474761450 ENST00000280326 deleterious(0.01) probably_damaging(0.938) - Cpn60_TCP1 5:10256256 5:10256144 86 5.61
link to download the report for this variant 182 182 HIS TYR 5uyx_D PDB Neutral none predicted - - - rs1387026985 ENST00000280326 tolerated(0.35) benign(0.033) - Cpn60_TCP1 5:10258236 5:10258124 86 5.48
link to download the report for this variant 182 182 HIS GLN 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs1471121762 ENST00000280326 tolerated(0.29) benign(0.034) - Cpn60_TCP1 5:10258238 5:10258126 1 3.71
link to download the report for this variant 183 183 ARG GLN 5uyx_D PDB Neutral none predicted - - 1.625e-05 rs772711272 ENST00000280326 tolerated(0.22) possibly_damaging(0.499) - Cpn60_TCP1 5:10258240 5:10258128 90 2.3
link to download the report for this variant 187 187 GLU GLN 5uyx_D PDB Neutral none predicted - - - rs1204572215 ENST00000280326 tolerated(0.24) possibly_damaging(0.58) - Cpn60_TCP1 5:10258251 5:10258139 90 5.59
link to download the report for this variant 193 193 VAL ILE 5uyx_D PDB Neutral none predicted - - 8.122e-06 rs978444316 ENST00000280326 tolerated(0.17) benign(0.078) - Cpn60_TCP1 5:10258269 5:10258157 28 3.64
link to download the report for this variant 195 195 THR ILE 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs1402526047 ENST00000280326 deleterious(0.01) possibly_damaging(0.67) - Cpn60_TCP1 5:10258276 5:10258164 54 5.59
link to download the report for this variant 196 196 VAL ILE 5uyx_D PDB Neutral none predicted - - - rs1444178041 ENST00000280326 deleterious(0.03) possibly_damaging(0.728) - Cpn60_TCP1 5:10258278 5:10258166 54 5.59
link to download the report for this variant 199 199 MET THR 5uyx_D PDB Neutral none predicted - - 2.437e-05 rs751271784 ENST00000280326 deleterious(0.04) benign(0.281) - Cpn60_TCP1 5:10258288 5:10258176 75 5.59
link to download the report for this variant 199 199 MET VAL 5uyx_D PDB Neutral none predicted - - - - - tolerated(0.12) benign(0.006) - Cpn60_TCP1 - - - -
link to download the report for this variant 204 204 VAL ILE 5uyx_D PDB Neutral none predicted - - - rs1266138297 ENST00000280326 tolerated(0.07) probably_damaging(0.949) - Cpn60_TCP1 5:10258302 5:10258190 75 5.59
link to download the report for this variant 206 206 PHE VAL 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs1334450162 ENST00000280326 deleterious(0) probably_damaging(1) - Cpn60_TCP1 5:10258308 5:10258196 81 5.59
link to download the report for this variant 208 208 LEU PHE 5uyx_D PDB Neutral none predicted - - - rs1181012937 ENST00000280326 tolerated(0.07) probably_damaging(0.987) - Cpn60_TCP1 5:10258314 5:10258202 81 5.59
link to download the report for this variant 213 213 GLY ASP 5uyx_C PDB Neutral none predicted - - 4.062e-05 rs764583584 ENST00000280326 deleterious(0.02) possibly_damaging(0.809) - Cpn60_TCP1 5:10258330 5:10258218 49 4.71
link to download the report for this variant 217 217 GLY SER 5uyx_B PDB Damaging Disallowed phi/psi; Gly in a bend - - 0.0002722 rs201804455 ENST00000280326 deleterious(0.03) probably_damaging(0.974) Yes Cpn60_TCP1 5:10258341 5:10258229 74 5.59
link to download the report for this variant 218 218 ARG THR 5uyx_C PDB Neutral none predicted - - - rs1454896427 ENST00000280326 tolerated(0.28) benign(0.297) Yes Cpn60_TCP1 5:10258345 5:10258233 74 5.59
link to download the report for this variant 220 220 GLU GLY 5uyx_C PDB Neutral none predicted - - - - - deleterious(0.05) probably_damaging(0.965) - Cpn60_TCP1 - - - -
link to download the report for this variant 221 221 ASP HIS 5uyx_C PDB Neutral none predicted - - - rs898527531 ENST00000280326 deleterious(0.02) probably_damaging(1) - Cpn60_TCP1 5:10258353 5:10258241 74 5.59
link to download the report for this variant 223 223 LYS GLU 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs745979403 ENST00000280326 tolerated(1) benign(0.039) - Cpn60_TCP1 5:10258359 5:10258247 0 3.31
link to download the report for this variant 223 223 LYS ILE 5uyx_D PDB Neutral none predicted - - 8.124e-06 rs1248524264 ENST00000280326 tolerated(0.19) benign(0) - Cpn60_TCP1 5:10258360 5:10258248 1 4.43
link to download the report for this variant 224 224 LEU VAL 5uyx_D PDB Neutral none predicted - - 2.031e-05 rs925661175 ENST00000280326 deleterious(0.01) probably_damaging(0.999) - Cpn60_TCP1 5:10258362 5:10258250 15 4.73
link to download the report for this variant 225 225 ILE MET 5uyx_D PDB Neutral none predicted - - 8.124e-06 rs758504808 ENST00000280326 deleterious(0) possibly_damaging(0.721) - Cpn60_TCP1 5:10258367 5:10258255 28 -5.54
link to download the report for this variant 228 228 VAL MET 5uyx_D PDB Neutral none predicted - - 5.687e-05 rs368338119 ENST00000280326 deleterious(0.02) probably_damaging(0.993) - Cpn60_TCP1 5:10258374 5:10258262 22 5.59
link to download the report for this variant 229 229 ILE VAL 5uyx_D PDB Neutral none predicted - - - - - tolerated(1) benign(0.026) - Cpn60_TCP1 - - - -
link to download the report for this variant 230 230 VAL MET 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs773084151 ENST00000280326 deleterious(0) possibly_damaging(0.892) - Cpn60_TCP1 5:10258380 5:10258268 10 5.59
link to download the report for this variant 231 231 ASP GLY 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs762850699 ENST00000280326 deleterious(0) probably_damaging(0.986) - Cpn60_TCP1 5:10258384 5:10258272 33 5.59
link to download the report for this variant 234 234 PHE ILE 5uyx_D PDB Damaging Buried H-bond breakage; Cavity altered; Buried / exposed switch - - 2.031e-05 rs770463902 ENST00000280326 tolerated(0.11) possibly_damaging(0.685) - Cpn60_TCP1 5:10258392 5:10258280 28 5.59
link to download the report for this variant 236 236 HIS ARG 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs1409950783 ENST00000280326 deleterious(0.01) probably_damaging(1) Yes Cpn60_TCP1 5:10258399 5:10258287 1 5.59
link to download the report for this variant 237 237 PRO SER 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs922131591 ENST00000280326 tolerated(0.19) benign(0.122) Yes Cpn60_TCP1 5:10258401 5:10258289 22 5.59
link to download the report for this variant 238 238 GLN GLU 5uyx_D PDB Neutral none predicted - - - rs1386038293 ENST00000280326 deleterious(0) probably_damaging(0.999) Yes Cpn60_TCP1 5:10258404 5:10258292 22 5.59
link to download the report for this variant 239 239 MET VAL 5uyx_D PDB Damaging Cavity altered - - 4.061e-06 rs372629115 ENST00000280326 deleterious(0) probably_damaging(0.997) - Cpn60_TCP1 5:10258407 5:10258295 22 5.59
link to download the report for this variant 241 241 LYS GLN 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs759287448 ENST00000280326 deleterious(0) probably_damaging(0.97) Yes Cpn60_TCP1 5:10258413 5:10258301 28 5.59
link to download the report for this variant 243 243 VAL GLU 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs1367645163 ENST00000280326 deleterious(0) possibly_damaging(0.832) - Cpn60_TCP1 5:10258502 5:10258390 28 5.59
link to download the report for this variant 245 245 ASP GLU 5uyx_D PDB Neutral none predicted - - 8.122e-06 rs747958037 ENST00000280326 deleterious(0.01) possibly_damaging(0.803) - Cpn60_TCP1 5:10258509 5:10258397 1 0.58
link to download the report for this variant 246 246 ALA VAL 5uyx_D PDB Neutral none predicted - - 3.249e-05 rs769622374 ENST00000280326 tolerated(0.26) benign(0.034) - Cpn60_TCP1 5:10258511 5:10258399 28 5.59
link to download the report for this variant 246 246 ALA GLY 5uyx_D PDB Neutral none predicted - - 3.249e-05 rs769622374 ENST00000280326 tolerated(0.26) benign(0.034) - Cpn60_TCP1 5:10258511 5:10258399 28 5.59
link to download the report for this variant 248 248 ILE MET 5uyx_D PDB Neutral none predicted - - 1.624e-05 rs144280885 ENST00000280326 deleterious(0.04) benign(0.2) - Cpn60_TCP1 5:10258518 5:10258406 10 0.35
link to download the report for this variant 248 248 ILE THR 5uyx_D PDB Neutral none predicted - - - rs1383276308 ENST00000280326 deleterious(0) possibly_damaging(0.561) - Cpn60_TCP1 5:10258517 5:10258405 0 5.59
link to download the report for this variant 249 249 ALA THR 5uyx_D PDB Neutral none predicted - - - rs1291878369 ENST00000280326 deleterious(0) probably_damaging(0.96) - Cpn60_TCP1 5:10258519 5:10258407 10 5.45
link to download the report for this variant 250 250 ILE VAL 5uyx_D PDB Neutral none predicted - - 3.249e-05 rs200819422 ENST00000280326 deleterious(0.04) probably_damaging(0.999) - Cpn60_TCP1 5:10258522 5:10258410 90 5.45
link to download the report for this variant 250 250 ILE SER 5uyx_D PDB Neutral none predicted - - - rs1366466878 ENST00000280326 deleterious(0.03) probably_damaging(1) - Cpn60_TCP1 5:10258523 5:10258411 90 5.45
link to download the report for this variant 254 254 PRO GLN 5uyx_D PDB Neutral none predicted - - - - - deleterious(0) probably_damaging(0.995) - Cpn60_TCP1 - - - -
link to download the report for this variant 255 255 PHE ILE 5uyx_D PDB Neutral none predicted - - - - - tolerated(0.07) probably_damaging(0.999) Yes Cpn60_TCP1 - - - -
link to download the report for this variant 257 257 PRO THR 5uyx_D PDB Neutral none predicted - - - rs1169397668 ENST00000280326 deleterious(0) probably_damaging(0.964) Yes Cpn60_TCP1 5:10258543 5:10258431 90 5.45
link to download the report for this variant 260 260 PRO ALA 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs765737541 ENST00000280326 deleterious(0.01) probably_damaging(0.996) Yes Cpn60_TCP1 5:10258552 5:10258440 39 5.45
link to download the report for this variant 263 263 LYS GLN 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs750814476 ENST00000280326 deleterious(0) probably_damaging(0.96) Yes Cpn60_TCP1 5:10258561 5:10258449 22 5.45
link to download the report for this variant 263 263 LYS GLU 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs750814476 ENST00000280326 deleterious(0) probably_damaging(0.96) Yes Cpn60_TCP1 5:10258561 5:10258449 22 5.45
link to download the report for this variant 265 265 LYS GLU 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs1351024571 ENST00000280326 tolerated(0.06) possibly_damaging(0.85) Yes Cpn60_TCP1 5:10258567 5:10258455 58 5.45
link to download the report for this variant 267 267 ASP HIS 5uyx_D PDB Neutral none predicted - - - rs1339440553 ENST00000280326 tolerated(0.06) benign(0.33) Yes Cpn60_TCP1 5:10258573 5:10258461 58 5.45
link to download the report for this variant 269 269 THR ILE 5uyx_D PDB Neutral none predicted - - 4.063e-06 rs989835897 ENST00000280326 deleterious(0.01) possibly_damaging(0.598) Yes Cpn60_TCP1 5:10258580 5:10258468 6 4.57
link to download the report for this variant 270 270 SER CYS 5uyx_D PDB Neutral none predicted - - 4.063e-06 rs763613936 ENST00000280326 deleterious(0.01) benign(0.072) Yes Cpn60_TCP1 5:10258583 5:10258471 15 5.35
link to download the report for this variant 272 272 GLU LYS 5uyx_D PDB Neutral none predicted - - 4.471e-05 rs781347459 ENST00000280326 deleterious(0.04) benign(0.007) Yes Cpn60_TCP1 5:10258588 5:10258476 6 5.35
link to download the report for this variant 273 273 ASP HIS 5uyx_D PDB Neutral none predicted - - 8.131e-06 rs751689306 ENST00000280326 tolerated(0.08) benign(0.2) Yes Cpn60_TCP1 5:10258591 5:10258479 76 5.35
link to download the report for this variant 273 273 ASP GLU 5uyx_D PDB Neutral none predicted - - - - - tolerated(1) benign(0.007) Yes Cpn60_TCP1 - - - -
link to download the report for this variant 274 274 TYR CYS 5uyx_D PDB Neutral none predicted - - - rs1203889004 ENST00000280326 deleterious(0) probably_damaging(0.994) Yes Cpn60_TCP1 5:10258595 5:10258483 76 -0.23
link to download the report for this variant 279 279 LYS THR 5uyx_D PDB Neutral none predicted - - 4.071e-06 rs754962890 ENST00000280326 tolerated(0.24) benign(0.155) - Cpn60_TCP1 5:10258610 5:10258498 83 4.19
link to download the report for this variant 287 287 GLU GLY 5uyx_D PDB Neutral none predicted - - 8.178e-06 rs921016368 ENST00000280326 deleterious(0.01) possibly_damaging(0.506) Yes Cpn60_TCP1 5:10258634 5:10258522 32 5.35
link to download the report for this variant 290 290 GLN GLU 5uyx_D PDB Neutral none predicted - - 8.191e-06 rs374472271 ENST00000280326 tolerated(0.61) benign(0) - Cpn60_TCP1 5:10258642 5:10258530 9 0.12
link to download the report for this variant 291 291 GLN HIS 5uyx_D PDB Neutral none predicted - - 4.1e-06 rs200034738 ENST00000280326 tolerated(0.12) possibly_damaging(0.905) Yes Cpn60_TCP1 5:10258647 5:10258535 - -10.7
link to download the report for this variant 291 291 GLN PRO 5uyx_D PDB Neutral none predicted - - 4.098e-06 rs1316302609 ENST00000280326 deleterious(0.03) possibly_damaging(0.864) Yes Cpn60_TCP1 5:10258646 5:10258534 0 5.35
link to download the report for this variant 293 293 LYS ARG 5uyx_D PDB Neutral none predicted - - 4.061e-05 rs148752621 ENST00000280326 deleterious(0) probably_damaging(0.969) - Cpn60_TCP1 5:10260908 5:10260796 54 5.79
link to download the report for this variant 294 294 GLU ASP 5uyx_D PDB Neutral none predicted - - - - - tolerated(1) benign(0.003) Yes Cpn60_TCP1 - - - -
link to download the report for this variant 296 296 GLY VAL 5uyx_D PDB Neutral none predicted - - - rs1339657729 ENST00000280326 deleterious(0) probably_damaging(1) - Cpn60_TCP1 5:10260917 5:10260805 54 5.79
link to download the report for this variant 297 297 ALA VAL 5uyx_D PDB Damaging Buried / exposed switch - - 4.061e-06 rs764237293 ENST00000280326 deleterious(0.04) probably_damaging(0.973) - Cpn60_TCP1 5:10260920 5:10260808 6 5.79
link to download the report for this variant 298 298 ASN ILE 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs1427949275 ENST00000280326 deleterious(0) possibly_damaging(0.904) - Cpn60_TCP1 5:10260923 5:10260811 1 5.79
link to download the report for this variant 307 307 ASP GLY 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs1272859494 ENST00000280326 deleterious(0) probably_damaging(1) Yes Cpn60_TCP1 5:10260950 5:10260838 62 5.79
link to download the report for this variant 308 308 ASP HIS 5uyx_D PDB Neutral none predicted - - - rs1173096363 ENST00000280326 deleterious(0) probably_damaging(1) Yes Cpn60_TCP1 5:10260952 5:10260840 62 5.79
link to download the report for this variant 312 312 HIS ASN 5uyx_D PDB Neutral none predicted - - - - - deleterious(0) probably_damaging(1) Yes Cpn60_TCP1 - - - -
link to download the report for this variant 313 313 LEU SER 5uyx_D PDB Neutral none predicted - - - rs1244791287 ENST00000280326 deleterious(0) probably_damaging(0.99) - Cpn60_TCP1 5:10260968 5:10260856 58 5.79
link to download the report for this variant 317 317 ASN LYS 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs1305236058 ENST00000280326 tolerated(0.24) benign(0.02) - Cpn60_TCP1 5:10260981 5:10260869 33 -5.15
link to download the report for this variant 320 320 PRO ARG 5uyx_D PDB Neutral none predicted - - 2.031e-05 rs746462495 ENST00000280326 deleterious(0.04) probably_damaging(0.993) - Cpn60_TCP1 5:10260989 5:10260877 0 5.79
link to download the report for this variant 320 320 PRO LEU 5uyx_D PDB Neutral none predicted - - 2.031e-05 rs746462495 ENST00000280326 deleterious(0.04) probably_damaging(0.993) - Cpn60_TCP1 5:10260989 5:10260877 0 5.79
link to download the report for this variant 321 321 ALA VAL 5uyx_D PDB Neutral none predicted - - - - - deleterious(0) probably_damaging(1) - Cpn60_TCP1 - - - -
link to download the report for this variant 322 322 VAL ILE 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs1199077485 ENST00000280326 tolerated(0.21) benign(0.155) - Cpn60_TCP1 5:10260994 5:10260882 26 5.79
link to download the report for this variant 325 325 VAL ILE 5uyx_D PDB Neutral none predicted - - 8.122e-06 rs1245333958 ENST00000280326 deleterious(0.05) probably_damaging(0.923) - Cpn60_TCP1 5:10261003 5:10260891 10 5.79
link to download the report for this variant 326 326 GLY GLU 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs776372121 ENST00000280326 deleterious(0) probably_damaging(1) - Cpn60_TCP1 5:10261007 5:10260895 71 5.79
link to download the report for this variant 328 328 PRO THR 5uyx_D PDB Neutral none predicted - - - rs943623000 ENST00000280326 tolerated(0.38) probably_damaging(0.989) - Cpn60_TCP1 5:10261012 5:10260900 71 5.79
link to download the report for this variant 332 332 LEU MET 5uyx_D PDB Neutral none predicted - - 2.031e-05 rs775929559 ENST00000280326 tolerated(0.06) probably_damaging(1) - Cpn60_TCP1 5:10261672 5:10261560 54 -0.44
link to download the report for this variant 336 336 ALA THR 5uyx_D PDB Neutral none predicted - - - - - deleterious(0.03) benign(0.384) - Cpn60_TCP1 - - - -
link to download the report for this variant 337 337 THR ALA 5uyx_D PDB Damaging Buried H-bond breakage - - 8.123e-06 rs111255743 ENST00000280326 deleterious(0) possibly_damaging(0.9) - Cpn60_TCP1 5:10261687 5:10261575 0 5.43
link to download the report for this variant 337 337 THR ILE 5uyx_D PDB Damaging Buried H-bond breakage - - 4.061e-06 rs1267907584 ENST00000280326 deleterious(0.03) probably_damaging(0.988) - Cpn60_TCP1 5:10261688 5:10261576 33 5.43
link to download the report for this variant 340 340 ARG TRP 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs998269335 ENST00000280326 deleterious(0) probably_damaging(0.996) Yes Cpn60_TCP1 5:10261696 5:10261584 0 4.56
link to download the report for this variant 340 340 ARG GLN 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs1248922135 ENST00000280326 tolerated(0.12) benign(0.379) Yes Cpn60_TCP1 5:10261697 5:10261585 15 5.43
link to download the report for this variant 342 342 VAL ILE 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs777159469 ENST00000280326 tolerated(0.21) benign(0.123) - Cpn60_TCP1 5:10261702 5:10261590 65 5.43
link to download the report for this variant 347 347 GLU GLN 5uyx_D PDB Neutral none predicted - - 1.218e-05 rs750191898 ENST00000280326 deleterious(0) probably_damaging(1) Yes Cpn60_TCP1 5:10261717 5:10261605 28 5.39
link to download the report for this variant 348 348 LEU PHE 5uyx_D PDB Neutral none predicted - - - rs951622250 ENST00000280326 deleterious(0) probably_damaging(0.99) Yes Cpn60_TCP1 5:10261720 5:10261608 28 5.39
link to download the report for this variant 349 349 THR ILE 5uyx_D PDB Neutral none predicted - - 8.122e-06 rs762786367 ENST00000280326 deleterious(0) possibly_damaging(0.71) Yes Cpn60_TCP1 5:10261724 5:10261612 15 5.39
link to download the report for this variant 349 349 THR ALA 5uyx_D PDB Neutral none predicted - - - rs1016532745 ENST00000280326 tolerated(0.06) benign(0.411) Yes Cpn60_TCP1 5:10261723 5:10261611 0 5.39
link to download the report for this variant 356 356 ALA THR 5uyx_D PDB Neutral none predicted - - - rs1294765017 ENST00000280326 deleterious(0.02) probably_damaging(1) - Cpn60_TCP1 5:10261744 5:10261632 76 5.39
link to download the report for this variant 358 358 LEU PHE 5uyx_D PDB Neutral none predicted - - 2.843e-05 rs777440322 ENST00000280326 tolerated(0.11) benign(0.367) - Cpn60_TCP1 5:10261750 5:10261638 6 1.27
link to download the report for this variant 359 359 VAL ILE 5uyx_D PDB Neutral none predicted - - 0.0001624 rs147989324 ENST00000280326 tolerated(0.18) benign(0.308) - Cpn60_TCP1 5:10261753 5:10261641 10 5.39
link to download the report for this variant 360 360 GLN LYS 5uyx_D PDB Neutral none predicted - - 0.0001624 rs368250896 ENST00000280326 tolerated(0.38) benign(0) - Cpn60_TCP1 5:10261756 5:10261644 0 3.26
link to download the report for this variant 360 360 GLN ARG 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs1344586481 ENST00000280326 tolerated(1) benign(0) - Cpn60_TCP1 5:10261757 5:10261645 10 2.92
link to download the report for this variant 361 361 GLU ASP 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs772476426 ENST00000280326 deleterious(0) probably_damaging(0.932) - Cpn60_TCP1 5:10261761 5:10261649 6 3.61
link to download the report for this variant 363 363 SER LEU 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs747585890 ENST00000280326 deleterious(0.01) benign(0.297) Yes Cpn60_TCP1 5:10261766 5:10261654 1 5.39
link to download the report for this variant 364 364 PHE LEU 5uyx_C PDB Neutral none predicted - - 2.03e-05 rs765584260 ENST00000280326 tolerated(0.19) possibly_damaging(0.823) - Cpn60_TCP1 5:10261768 5:10261656 0 5.39
link to download the report for this variant 364 364 PHE CYS 5uyx_C PDB Neutral none predicted - - 4.061e-06 rs776587777 ENST00000280326 deleterious(0) probably_damaging(0.998) - Cpn60_TCP1 5:10261769 5:10261657 90 5.39
link to download the report for this variant 364 364 PHE SER 5uyx_C PDB Neutral none predicted - - 4.061e-06 rs776587777 ENST00000280326 deleterious(0) probably_damaging(0.998) - Cpn60_TCP1 5:10261769 5:10261657 90 5.39
link to download the report for this variant 374 374 ILE THR 5uyx_D PDB Neutral none predicted - - 8.122e-06 rs769929695 ENST00000280326 deleterious(0) probably_damaging(0.955) - Cpn60_TCP1 5:10261799 5:10261687 0 5.39
link to download the report for this variant 374 374 ILE MET 5uyx_D PDB Neutral none predicted - - 8.122e-06 rs773531721 ENST00000280326 deleterious(0) probably_damaging(0.991) - Cpn60_TCP1 5:10261800 5:10261688 0 -6.48
link to download the report for this variant 375 375 GLU LYS 5uyx_D PDB Neutral none predicted - - 8.122e-06 rs139449863 ENST00000280326 tolerated(0.06) possibly_damaging(0.801) - Cpn60_TCP1 5:10261801 5:10261689 39 5.39
link to download the report for this variant 381 381 ARG THR 4V94_E MODEL Neutral none predicted - - - - - deleterious(0.01) possibly_damaging(0.603) - Cpn60_TCP1 - - - -
link to download the report for this variant 382 382 ALA VAL 5uyx_D PDB Neutral none predicted - - - rs1477590101 ENST00000280326 deleterious(0.03) possibly_damaging(0.458) - Cpn60_TCP1 5:10261823 5:10261711 80 5.39
link to download the report for this variant 385 385 ILE VAL 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs913771814 ENST00000280326 tolerated(0.37) benign(0.122) - Cpn60_TCP1 5:10261831 5:10261719 68 4.23
link to download the report for this variant 387 387 ILE LEU 5uyx_D PDB Neutral none predicted - - - rs946603531 ENST00000280326 tolerated(0.31) benign(0.014) - Cpn60_TCP1 5:10261837 5:10261725 68 5.39
link to download the report for this variant 388 388 ARG THR 5uyx_C PDB Neutral none predicted - - - - - deleterious(0) probably_damaging(0.999) - Cpn60_TCP1 - - - -
link to download the report for this variant 389 389 GLY ARG 5uyx_C PDB Neutral none predicted - - - rs1265171730 ENST00000280326 deleterious(0.02) possibly_damaging(0.558) - Cpn60_TCP1 5:10261843 5:10261731 68 5.39
link to download the report for this variant 390 390 GLY GLU 5uyx_C PDB Damaging Gly in a bend - - 4.063e-06 rs1349214987 ENST00000280326 deleterious(0) probably_damaging(0.939) - Cpn60_TCP1 5:10261847 5:10261735 6 5.39
link to download the report for this variant 391 391 ASN SER 5uyx_C PDB Neutral none predicted - - 4.063e-06 rs1411993199 ENST00000280326 tolerated(0.18) benign(0.26) Yes Cpn60_TCP1 5:10261850 5:10261738 10 5.39
link to download the report for this variant 392 392 LYS ASN 5uyx_C PDB Neutral none predicted - - 8.127e-06 rs759556512 ENST00000280326 deleterious(0.04) possibly_damaging(0.876) Yes Cpn60_TCP1 5:10261854 5:10261742 28 3.16
link to download the report for this variant 398 398 ALA VAL 5uyx_C PDB Neutral none predicted - - 8.122e-06 rs201810364 ENST00000280326 deleterious(0.02) benign(0.358) - Cpn60_TCP1 5:10262606 5:10262494 22 4.95
link to download the report for this variant 400 400 ARG LEU 5uyx_C PDB Neutral none predicted - - 1.624e-05 rs749310473 ENST00000280326 deleterious(0) probably_damaging(0.95) - Cpn60_TCP1 5:10262612 5:10262500 39 4.95
link to download the report for this variant 403 403 HIS ARG 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs1302351192 ENST00000280326 tolerated(0.15) probably_damaging(0.925) - Cpn60_TCP1 5:10262621 5:10262509 1 4.95
link to download the report for this variant 404 404 ASP ASN 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs774663416 ENST00000280326 deleterious(0) probably_damaging(0.955) - Cpn60_TCP1 5:10262623 5:10262511 58 4.95
link to download the report for this variant 408 408 VAL ASP 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs1349631169 ENST00000280326 deleterious(0) probably_damaging(0.965) - Cpn60_TCP1 5:10262636 5:10262524 15 4.95
link to download the report for this variant 409 409 ILE VAL 5uyx_D PDB Neutral none predicted - - - - - tolerated(1) benign(0.018) - Cpn60_TCP1 - - - -
link to download the report for this variant 410 410 ARG TRP 5uyx_D PDB Damaging Buried H-bond breakage - - 4.061e-06 rs923206809 ENST00000280326 deleterious(0.02) benign(0.262) - Cpn60_TCP1 5:10262641 5:10262529 0 4.02
link to download the report for this variant 410 410 ARG GLN 5uyx_D PDB Neutral none predicted - - 2.437e-05 rs771944850 ENST00000280326 deleterious(0) probably_damaging(0.964) - Cpn60_TCP1 5:10262642 5:10262530 39 4.95
link to download the report for this variant 413 413 ILE VAL 5uyx_D PDB Neutral none predicted - - - rs201013299 ENST00000280326 tolerated(0.72) benign(0.007) - Cpn60_TCP1 5:10262650 5:10262538 0 2.27
link to download the report for this variant 413 413 ILE THR 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs187490382 ENST00000280326 deleterious(0) benign(0.347) - Cpn60_TCP1 5:10262651 5:10262539 1 4.95
link to download the report for this variant 414 414 ARG HIS 5uyx_D PDB Neutral none predicted - - - - - deleterious(0.01) benign(0.021) Yes Cpn60_TCP1 - - - -
link to download the report for this variant 414 414 ARG CYS 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs200430696 ENST00000280326 deleterious(0.01) possibly_damaging(0.893) Yes Cpn60_TCP1 5:10262653 5:10262541 6 5.09
link to download the report for this variant 415 415 ASP ASN 5uyx_D PDB Neutral none predicted - - 2.437e-05 rs11557654 ENST00000280326 tolerated(0.12) benign(0.177) - Cpn60_TCP1 5:10262656 5:10262544 22 5.09
link to download the report for this variant 416 416 ASN ASP 5uyx_D PDB Neutral none predicted - - - rs1456581750 ENST00000280326 tolerated(0.12) benign(0.007) - Cpn60_TCP1 5:10262659 5:10262547 22 5.09
link to download the report for this variant 417 417 ARG CYS 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs776123781 ENST00000280326 deleterious(0) probably_damaging(0.954) - Cpn60_TCP1 5:10262662 5:10262550 45 5.09
link to download the report for this variant 417 417 ARG HIS 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs761273276 ENST00000280326 deleterious(0.03) benign(0.053) - Cpn60_TCP1 5:10262663 5:10262551 45 5.09
link to download the report for this variant 420 420 TYR CYS 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs748625875 ENST00000280326 deleterious(0.04) probably_damaging(0.994) - Cpn60_TCP1 5:10262672 5:10262560 49 5.09
link to download the report for this variant 424 424 ALA SER 5uyx_D PDB Neutral none predicted - - 1.218e-05 rs767982457 ENST00000280326 tolerated(0.64) benign(0.437) - Cpn60_TCP1 5:10262683 5:10262571 10 5.09
link to download the report for this variant 425 425 ALA VAL 5uyx_D PDB Neutral none predicted - - 8.122e-06 rs756645693 ENST00000280326 tolerated(0.13) possibly_damaging(0.555) - Cpn60_TCP1 5:10262687 5:10262575 33 5.09
link to download the report for this variant 428 428 SER TYR 5uyx_D PDB Damaging Buried / exposed switch - - 5.685e-05 rs201280643 ENST00000280326 deleterious(0.03) probably_damaging(0.918) - Cpn60_TCP1 5:10262696 5:10262584 22 5.09
link to download the report for this variant 428 428 SER CYS 5uyx_D PDB Neutral none predicted - - 5.685e-05 rs201280643 ENST00000280326 deleterious(0.03) probably_damaging(0.918) - Cpn60_TCP1 5:10262696 5:10262584 22 5.09
link to download the report for this variant 428 428 SER THR 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs1357470909 ENST00000280326 tolerated(0.19) benign(0.072) - Cpn60_TCP1 5:10262695 5:10262583 0 -5.54
link to download the report for this variant 430 430 ALA GLY 5uyx_D PDB Neutral none predicted - - 8.122e-06 rs757459371 ENST00000280326 deleterious(0.04) benign(0.107) - Cpn60_TCP1 5:10262702 5:10262590 33 5.09
link to download the report for this variant 432 432 ALA VAL 5uyx_D PDB Neutral none predicted - - 8.122e-06 rs369196153 ENST00000280326 deleterious(0.05) possibly_damaging(0.672) - Cpn60_TCP1 5:10262708 5:10262596 33 5.09
link to download the report for this variant 433 433 VAL ILE 5uyx_D PDB Neutral none predicted - - 8.122e-06 rs746171086 ENST00000280326 tolerated(0.17) benign(0.097) - Cpn60_TCP1 5:10262710 5:10262598 58 5.09
link to download the report for this variant 436 436 GLU LYS 5uyx_D PDB Neutral none predicted - - - rs1330528159 ENST00000280326 tolerated(0.37) benign(0.021) - Cpn60_TCP1 5:10262719 5:10262607 58 5.09
link to download the report for this variant 437 437 ALA VAL 5uyx_D PDB Neutral none predicted - - 4.875e-05 rs149067488 ENST00000280326 deleterious(0.04) benign(0.325) - Cpn60_TCP1 5:10262723 5:10262611 6 5.09
link to download the report for this variant 438 438 ASP GLY 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs1298787727 ENST00000280326 deleterious(0.02) possibly_damaging(0.85) Yes Cpn60_TCP1 5:10262726 5:10262614 6 5.09
link to download the report for this variant 440 440 CYS GLY 5uyx_D PDB Neutral none predicted - - - rs890262012 ENST00000280326 tolerated(0.15) benign(0.08) - Cpn60_TCP1 5:10263246 5:10263134 15 5.63
link to download the report for this variant 441 441 PRO HIS 5uyx_D PDB Neutral none predicted - - - rs773923668 ENST00000280326 deleterious(0.03) possibly_damaging(0.667) Yes Cpn60_TCP1 5:10263250 5:10263138 6 5.63
link to download the report for this variant 441 441 PRO ALA 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs1321343522 ENST00000280326 tolerated(0.28) benign(0.003) Yes Cpn60_TCP1 5:10263249 5:10263137 6 5.63
link to download the report for this variant 442 442 THR ILE 5uyx_D PDB Neutral none predicted - - - rs1425929845 ENST00000280326 deleterious(0) possibly_damaging(0.46) Yes Cpn60_TCP1 5:10263253 5:10263141 74 5.63
link to download the report for this variant 448 448 MET VAL 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs1319522983 ENST00000280326 tolerated(0.3) benign(0.003) - Cpn60_TCP1 5:10263270 5:10263158 10 5.63
link to download the report for this variant 450 450 ALA VAL 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs765772467 ENST00000280326 deleterious(0.03) benign(0.099) - Cpn60_TCP1 5:10263277 5:10263165 33 5.63
link to download the report for this variant 453 453 ASP ASN 5uyx_D PDB Neutral none predicted - - 2.031e-05 rs766463234 ENST00000280326 tolerated(0.17) benign(0.027) Yes Cpn60_TCP1 5:10263285 5:10263173 6 5.63
link to download the report for this variant 454 454 ALA THR 5uyx_D PDB Neutral none predicted - - - - - deleterious(0) benign(0.321) - Cpn60_TCP1 - - - -
link to download the report for this variant 454 454 ALA PRO 5uyx_D PDB Damaging Buried Pro introduced - - - - - deleterious(0.01) probably_damaging(0.99) - Cpn60_TCP1 - - - -
link to download the report for this variant 454 454 ALA VAL 5uyx_D PDB Neutral none predicted - - - rs1251452039 ENST00000280326 deleterious(0) possibly_damaging(0.865) - Cpn60_TCP1 5:10263289 5:10263177 28 5.63
link to download the report for this variant 456 456 GLU GLY 5uyx_D PDB Neutral none predicted - - 8.123e-06 rs755176898 ENST00000280326 deleterious(0) probably_damaging(0.957) - Cpn60_TCP1 5:10263295 5:10263183 49 5.63
link to download the report for this variant 460 460 MET VAL 5uyx_D PDB Neutral none predicted - - 1.219e-05 rs780975626 ENST00000280326 deleterious(0.04) benign(0.076) Yes Cpn60_TCP1 5:10263306 5:10263194 0 5.63
link to download the report for this variant 460 460 MET THR 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs376067681 ENST00000280326 tolerated(0.07) benign(0.245) Yes Cpn60_TCP1 5:10263307 5:10263195 1 5.63
link to download the report for this variant 461 461 ALA SER 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs756076307 ENST00000280326 deleterious(0.05) benign(0.367) - Cpn60_TCP1 5:10263309 5:10263197 0 5.63
link to download the report for this variant 461 461 ALA VAL 5uyx_D PDB Neutral none predicted - - 1.219e-05 rs777521929 ENST00000280326 tolerated(0.09) probably_damaging(0.94) - Cpn60_TCP1 5:10263310 5:10263198 1 5.63
link to download the report for this variant 462 462 LEU PHE 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs146715762 ENST00000280326 deleterious(0) probably_damaging(1) - Cpn60_TCP1 5:10263312 5:10263200 28 5.63
link to download the report for this variant 464 464 GLU GLY 5uyx_D PDB Neutral none predicted - - 4.874e-05 rs770386557 ENST00000280326 deleterious(0.01) probably_damaging(1) Yes Cpn60_TCP1 5:10263319 5:10263207 39 5.63
link to download the report for this variant 466 466 SER CYS 5uyx_D PDB Neutral none predicted - - - rs1162324764 ENST00000280326 deleterious(0.04) benign(0.166) Yes Cpn60_TCP1 5:10263324 5:10263212 39 5.63
link to download the report for this variant 467 467 GLY VAL 5uyx_D PDB Neutral none predicted - - - rs745574825 ENST00000280326 deleterious(0) probably_damaging(1) Yes Cpn60_TCP1 5:10263328 5:10263216 6 5.63
link to download the report for this variant 467 467 GLY ALA 5uyx_D PDB Neutral none predicted - - - rs745574825 ENST00000280326 deleterious(0) probably_damaging(1) Yes Cpn60_TCP1 5:10263328 5:10263216 6 5.63
link to download the report for this variant 468 468 MET VAL 5uyx_D PDB Neutral none predicted - - 1.625e-05 rs140347348 ENST00000280326 deleterious(0.03) benign(0.021) Yes Cpn60_TCP1 5:10263330 5:10263218 0 4.44
link to download the report for this variant 468 468 MET THR 5uyx_D PDB Neutral none predicted - - 1.219e-05 rs771793931 ENST00000280326 deleterious(0) benign(0.143) Yes Cpn60_TCP1 5:10263331 5:10263219 39 5.63
link to download the report for this variant 469 469 ASN SER 5uyx_D PDB Neutral none predicted - - - rs1438094403 ENST00000280326 tolerated(0.93) benign(0.007) Yes Cpn60_TCP1 5:10263334 5:10263222 39 5.63
link to download the report for this variant 471 471 ILE THR 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs777140569 ENST00000280326 deleterious(0) probably_damaging(0.909) Yes Cpn60_TCP1 5:10263340 5:10263228 33 5.63
link to download the report for this variant 471 471 ILE VAL 5uyx_D PDB Neutral none predicted - - - rs1369528017 ENST00000280326 tolerated(0.09) benign(0.136) Yes Cpn60_TCP1 5:10263339 5:10263227 0 5.63
link to download the report for this variant 474 474 MET VAL 5uyx_D PDB Neutral none predicted - - 2.031e-05 rs762233154 ENST00000280326 tolerated(0.37) benign(0.001) - Cpn60_TCP1 5:10263348 5:10263236 60 5.63
link to download the report for this variant 477 477 VAL LEU 5uyx_D PDB Neutral none predicted - - - rs773643978 ENST00000280326 tolerated(0.85) benign(0.015) - Cpn60_TCP1 5:10263357 5:10263245 60 5.63
link to download the report for this variant 479 479 ALA VAL 5uyx_D PDB Neutral none predicted - - 4.063e-06 rs1282981380 ENST00000280326 deleterious(0.04) possibly_damaging(0.87) Yes Cpn60_TCP1 5:10263364 5:10263252 6 5.63
link to download the report for this variant 480 480 ARG LYS 5uyx_D PDB Neutral none predicted - - 4.063e-06 rs958616251 ENST00000280326 tolerated(0.46) benign(0.003) - Cpn60_TCP1 5:10263367 5:10263255 6 3.85
link to download the report for this variant 481 481 GLN HIS 5uyx_D PDB Damaging Buried charge introduced - - 9.751e-05 rs766425367 ENST00000280326 tolerated(0.14) benign(0.133) - Cpn60_TCP1 5:10263371 5:10263259 0 -3.04
link to download the report for this variant 481 481 GLN LEU 5uyx_D PDB Damaging Buried H-bond breakage - - 4.063e-06 rs375176582 ENST00000280326 deleterious(0.02) probably_damaging(0.932) - Cpn60_TCP1 5:10263370 5:10263258 0 5.63
link to download the report for this variant 482 482 VAL MET 5uyx_D PDB Neutral none predicted - - 8.126e-06 rs751597197 ENST00000280326 tolerated(0.1) possibly_damaging(0.73) - Cpn60_TCP1 5:10263372 5:10263260 6 5.63
link to download the report for this variant 483 483 LYS GLU 5uyx_D PDB Neutral none predicted - - 4.063e-06 rs755193358 ENST00000280326 tolerated(0.34) benign(0.006) - Cpn60_TCP1 5:10263375 5:10263263 54 5.63
link to download the report for this variant 487 487 PRO ALA 5uyx_D PDB Neutral none predicted - - 4.065e-06 rs752510946 ENST00000280326 tolerated(0.53) benign(0.015) - Cpn60_TCP1 5:10263387 5:10263275 0 4.77
link to download the report for this variant 487 487 PRO SER 5uyx_D PDB Neutral none predicted - - 4.065e-06 rs752510946 ENST00000280326 tolerated(0.53) benign(0.015) - Cpn60_TCP1 5:10263387 5:10263275 0 4.77
link to download the report for this variant 487 487 PRO ARG 5uyx_D PDB Neutral none predicted - - 4.065e-06 rs1239159196 ENST00000280326 deleterious(0.03) possibly_damaging(0.511) - Cpn60_TCP1 5:10263388 5:10263276 15 5.63
link to download the report for this variant 488 488 ALA GLY 5uyx_D PDB Neutral none predicted - - - rs1204159705 ENST00000280326 tolerated(0.32) benign(0.122) - Cpn60_TCP1 5:10263391 5:10263279 15 5.63
link to download the report for this variant 488 488 ALA THR 5uyx_D PDB Neutral none predicted - - - rs1349545475 ENST00000280326 tolerated(0.39) benign(0.011) - Cpn60_TCP1 5:10263390 5:10263278 15 5.63
link to download the report for this variant 489 489 LEU PHE 5uyx_D PDB Neutral none predicted - - 8.135e-06 rs1181197986 ENST00000280326 tolerated(0.11) benign(0.133) - Cpn60_TCP1 5:10263393 5:10263281 22 4.77
link to download the report for this variant 491 491 ILE VAL 5uyx_D PDB Neutral none predicted - - 4.072e-06 rs777591810 ENST00000280326 tolerated(0.89) benign(0.027) - Cpn60_TCP1 5:10263399 5:10263287 6 5.63
link to download the report for this variant 495 495 HIS LEU 5uyx_D PDB Neutral none predicted - - 4.101e-06 rs778301575 ENST00000280326 tolerated(0.25) benign(0) Yes Cpn60_TCP1 5:10263412 5:10263300 1 5.63
link to download the report for this variant 495 495 HIS PRO 5uyx_D PDB Damaging Disallowed phi/psi - - 4.101e-06 rs778301575 ENST00000280326 tolerated(0.25) benign(0) Yes Cpn60_TCP1 5:10263412 5:10263300 1 5.63
link to download the report for this variant 496 496 LYS GLU 5uyx_D PDB Neutral none predicted - - 1.235e-05 rs745315091 ENST00000280326 tolerated(0.41) benign(0.093) Yes Cpn60_TCP1 5:10263414 5:10263302 15 4.44
link to download the report for this variant 498 498 THR ARG 5uyx_D PDB Neutral none predicted - - 4.17e-06 rs145513026 ENST00000280326 tolerated(0.06) possibly_damaging(0.798) - Cpn60_TCP1 5:10263421 5:10263309 1 4.75
link to download the report for this variant 499 499 ASN HIS 5uyx_D PDB Neutral none predicted - - 4.167e-06 rs1377829085 ENST00000280326 tolerated(0.09) possibly_damaging(0.631) - Cpn60_TCP1 5:10263423 5:10263311 0 5.63
link to download the report for this variant 499 499 ASN SER 5uyx_D PDB Neutral none predicted - - 4.119e-06 rs746640794 ENST00000280326 tolerated(0.16) benign(0.007) - Cpn60_TCP1 5:10263424 5:10263312 14 5.63
link to download the report for this variant 501 501 MET THR 5uyx_D PDB Neutral none predicted - - 4.065e-06 rs776965161 ENST00000280326 deleterious(0) probably_damaging(0.997) - Cpn60_TCP1 5:10264771 5:10264659 1 5.58
link to download the report for this variant 501 501 MET LEU 5uyx_D PDB Neutral none predicted - - - rs768784172 ENST00000280326 deleterious(0.03) probably_damaging(0.99) - Cpn60_TCP1 5:10264770 5:10264658 0 5.58
link to download the report for this variant 501 501 MET VAL 5uyx_D PDB Neutral none predicted - - - rs768784172 ENST00000280326 deleterious(0.03) probably_damaging(0.99) - Cpn60_TCP1 5:10264770 5:10264658 0 5.58
link to download the report for this variant 502 502 LYS GLU 5uyx_D PDB Neutral none predicted - - 4.065e-06 rs761913921 ENST00000280326 deleterious(0.04) benign(0.075) - Cpn60_TCP1 5:10264773 5:10264661 45 4.41
link to download the report for this variant 505 505 HIS ARG 5uyx_D PDB Neutral none predicted - - 8.128e-06 rs765194207 ENST00000280326 tolerated(0.34) benign(0.34) - Cpn60_TCP1 5:10264783 5:10264671 1 5.58
link to download the report for this variant 506 506 VAL ILE 5uyx_D PDB Neutral none predicted - - 1.219e-05 rs773131641 ENST00000280326 tolerated(0.16) possibly_damaging(0.897) - Cpn60_TCP1 5:10264785 5:10264673 6 5.58
link to download the report for this variant 507 507 ILE VAL 5uyx_D PDB Neutral none predicted - - 0.0001504 rs138168151 ENST00000280326 tolerated(0.22) benign(0.009) - Cpn60_TCP1 5:10264788 5:10264676 22 5.58
link to download the report for this variant 509 509 THR ALA 5uyx_D PDB Damaging Buried H-bond breakage; Cavity altered - - 4.064e-06 rs766376854 ENST00000280326 tolerated(0.43) benign(0.136) - Cpn60_TCP1 5:10264794 5:10264682 15 5.58
link to download the report for this variant 509 509 THR SER 5uyx_D PDB Damaging Cavity altered - - 4.064e-06 rs766376854 ENST00000280326 tolerated(0.43) benign(0.136) - Cpn60_TCP1 5:10264794 5:10264682 15 5.58
link to download the report for this variant 510 510 LEU PHE 5uyx_D PDB Neutral none predicted - - 4.064e-06 rs751049553 ENST00000280326 tolerated(0.1) probably_damaging(0.989) - Cpn60_TCP1 5:10264799 5:10264687 0 3.81
link to download the report for this variant 511 511 ILE LEU 5uyx_D PDB Neutral none predicted - - 4.064e-06 rs1371795977 ENST00000280326 tolerated(0.43) benign(0.001) - Cpn60_TCP1 5:10264800 5:10264688 45 5.58
link to download the report for this variant 513 513 LYS GLU 5uyx_D PDB Damaging Buried charge switch; Buried H-bond breakage; Buried salt bridge breakage; Cavity altered - - - rs1466211340 ENST00000280326 deleterious(0) probably_damaging(0.999) - Cpn60_TCP1 5:10264806 5:10264694 45 5.58
link to download the report for this variant 514 514 LYS MET 5uyx_D PDB Neutral none predicted - - 1.219e-05 rs754562087 ENST00000280326 deleterious(0.01) probably_damaging(0.983) - Cpn60_TCP1 5:10264810 5:10264698 33 5.58
link to download the report for this variant 514 514 LYS ASN 5uyx_D PDB Neutral none predicted - - - rs1180462443 ENST00000280326 tolerated(0.06) probably_damaging(0.909) - Cpn60_TCP1 5:10264811 5:10264699 33 4.7
link to download the report for this variant 517 517 ILE MET 5uyx_D PDB Neutral none predicted - - 4.064e-06 rs567760368 ENST00000280326 tolerated(0.06) probably_damaging(0.91) - Cpn60_TCP1 5:10264820 5:10264708 0 -4.0
link to download the report for this variant 517 517 ILE LEU 5uyx_D PDB Neutral none predicted - - 1.219e-05 rs752461300 ENST00000280326 tolerated(0.12) benign(0.095) - Cpn60_TCP1 5:10264818 5:10264706 1 5.58
link to download the report for this variant 517 517 ILE VAL 5uyx_D PDB Neutral none predicted - - 1.219e-05 rs752461300 ENST00000280326 tolerated(0.12) benign(0.095) - Cpn60_TCP1 5:10264818 5:10264706 1 5.58
link to download the report for this variant 518 518 SER TYR 5uyx_D PDB Neutral none predicted - - - - - tolerated(0.45) possibly_damaging(0.629) Yes Cpn60_TCP1 - - - -
link to download the report for this variant 518 518 SER PRO 5uyx_D PDB Neutral none predicted - - 4.064e-06 rs1264623243 ENST00000280326 tolerated(0.19) possibly_damaging(0.567) Yes Cpn60_TCP1 5:10264821 5:10264709 22 5.58
link to download the report for this variant 520 520 ALA THR 5uyx_D PDB Neutral none predicted - - 4.064e-06 rs1354077018 ENST00000280326 deleterious(0) probably_damaging(0.92) - Cpn60_TCP1 5:10264827 5:10264715 81 5.58
link to download the report for this variant 524 524 VAL ALA 5uyx_D PDB Neutral none predicted - - - rs1377434629 ENST00000280326 tolerated(0.29) benign(0.21) - Cpn60_TCP1 5:10264840 5:10264728 81 5.58
link to download the report for this variant 527 527 ILE SER 5uyx_D PDB Neutral none predicted - - 8.128e-06 rs755706741 ENST00000280326 deleterious(0) probably_damaging(0.996) - Cpn60_TCP1 5:10264849 5:10264737 78 5.58
link to download the report for this variant 534 534 ARG HIS 5uyx_C PDB Neutral none predicted - - 4.064e-06 rs779262060 ENST00000280326 tolerated(0.29) benign(0.212) Yes - 5:10264870 5:10264758 62 5.58
link to download the report for this variant 534 534 ARG CYS 5uyx_C PDB Neutral none predicted - - 4.065e-06 rs375499316 ENST00000280326 tolerated(0.1) probably_damaging(0.976) Yes - 5:10264869 5:10264757 0 5.58
link to download the report for this variant 535 535 LYS GLN 5uyx_C PDB Neutral none predicted - - - rs1277979024 ENST00000280326 tolerated(0.58) benign(0.049) Yes - 5:10264872 5:10264760 62 5.58
link to download the report for this variant 31 31 LEU VAL 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs765272975 ENST00000506600 deleterious(0.02) probably_damaging(0.973) Yes - 5:10256105 5:10255993 28 3.81
link to download the report for this variant 41 41 ALA THR 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs374488155 ENST00000506600 deleterious(0.03) benign(0.05) - - 5:10256135 5:10256023 6 5.61
link to download the report for this variant 49 49 ARG CYS 5uyx_D PDB Neutral none predicted - - 7.717e-05 rs572671693 ENST00000506600 deleterious(0.04) benign(0.035) - Cpn60_TCP1 5:10256159 5:10256047 0 5.61
link to download the report for this variant 49 49 ARG HIS 5uyx_D PDB Neutral none predicted - - 2.437e-05 rs200433052 ENST00000506600 tolerated(0.05) benign(0.009) - Cpn60_TCP1 5:10256160 5:10256048 1 5.61
link to download the report for this variant 62 62 VAL ALA 5uyx_D PDB Neutral none predicted - - - rs201103056 ENST00000506600 deleterious(0.05) benign(0.102) Yes Cpn60_TCP1 5:10256199 5:10256087 10 5.61
link to download the report for this variant 62 62 VAL ILE 5uyx_D PDB Neutral none predicted - - 2.033e-05 rs760589901 ENST00000506600 tolerated(0.89) benign(0.001) Yes Cpn60_TCP1 5:10256198 5:10256086 10 3.65
link to download the report for this variant 65 65 ASP ASN 5uyx_D PDB Neutral none predicted - - 8.134e-06 rs1336981943 ENST00000506600 tolerated(0.27) benign(0.022) Yes Cpn60_TCP1 5:10256207 5:10256095 0 5.61
link to download the report for this variant 65 65 ASP GLY 5uyx_D PDB Neutral none predicted - - 4.067e-06 rs1215951935 ENST00000506600 tolerated(0.1) benign(0.022) Yes Cpn60_TCP1 5:10256208 5:10256096 1 5.61
link to download the report for this variant 69 69 THR SER 5uyx_D PDB Neutral none predicted - - 4.069e-06 rs748484897 ENST00000506600 tolerated(0.72) benign(0.012) - Cpn60_TCP1 5:10256219 5:10256107 6 3.14
link to download the report for this variant 69 69 THR ALA 5uyx_D PDB Neutral none predicted - - 4.069e-06 rs748484897 ENST00000506600 tolerated(0.72) benign(0.012) - Cpn60_TCP1 5:10256219 5:10256107 6 3.14
link to download the report for this variant 111 111 VAL ILE 5uyx_D PDB Neutral none predicted - - - rs1266138297 ENST00000506600 tolerated(0.06) possibly_damaging(0.788) - Cpn60_TCP1 5:10258302 5:10258190 75 5.59
link to download the report for this variant 164 164 PRO THR 5uyx_D PDB Neutral none predicted - - - rs1169397668 ENST00000506600 deleterious(0) possibly_damaging(0.491) - Cpn60_TCP1 5:10258543 5:10258431 90 5.45
link to download the report for this variant 270 270 SER LEU 5uyx_D PDB Neutral none predicted - - 4.061e-06 rs747585890 ENST00000506600 deleterious(0.01) benign(0.222) Yes Cpn60_TCP1 5:10261766 5:10261654 1 5.39
link to download the report for this variant 292 292 ILE VAL 5uyx_D PDB Neutral none predicted - - 4.062e-06 rs913771814 ENST00000506600 tolerated(0.34) benign(0.173) - Cpn60_TCP1 5:10261831 5:10261719 68 4.23
link to download the report for this variant 296 296 GLY ARG 5uyx_D PDB Neutral none predicted - - - rs1265171730 ENST00000506600 deleterious(0.01) probably_damaging(0.914) - Cpn60_TCP1 5:10261843 5:10261731 68 5.39
link to download the report for this variant 298 298 ASN SER 5uyx_D PDB Neutral none predicted - - 4.063e-06 rs1411993199 ENST00000506600 tolerated(0.16) benign(0.402) - Cpn60_TCP1 5:10261850 5:10261738 10 5.39


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version 1.5.4 22/11/22