Missense3D-DB results

(structural effect of missense variants)

Note: In this version of the database, the structural analysis is based on the impact of a variant on the protein tertiary structure. The missense variant may disrupt additional features (e.g. protein-protein interactions or functional sites) that we are currently not capturing.

UniProt ID: Q07912     Gene name: TNK2     pLI score: 0.0 tooltip info, click for explanation of pLI score     RVIS score: 1.13 (89.0 %) tooltip info, click for explanation of RVIS scores

tooltip info, click on the Download Report checkbox to display the column which supports the download of a custom report in the results table    tooltip info, click on the UniProt Position checkbox to display the uniprot position column in the results table    tooltip info, click on the PDB/Model Position checkbox to display the PDB or Model position column in the results table    tooltip info, click on the Residue Wildtype checkbox to display the wildtype residue column in the results table    tooltip info, click on the Residue Mutant checkbox to display the mutant residue column in the results table    tooltip info, click on the Structure checkbox to display the PDB/structure id column in the results table    tooltip info, click on the Structure Type checkbox to display the PDB/Phyre model column in the results table    tooltip info, click on the Missense3D Prediction checkbox to display the Missense3D Prediction column in the results table    tooltip info, click on the Structural damage predicted checkbox to display the column detailing whether structural damage is predicted in the results table    tooltip info, click on the Humsavar annotation checkbox to display the Humsavar annotation column in the results table    tooltip info, click on the ClinVar annotation checkbox to display the ClinVar annotation column in the results table    tooltip info, click on the MAF score checkbox to display the MAF score column in the results table    tooltip info, click on the dbSNP checkbox to display the dbSNP id column in the results table    tooltip info, click on the Ensemble ID checkbox to display the Ensemble ID column in the results table    tooltip info, click on the SIFT prediction(score) checkbox to display the SIFT prediction and score column in the results table    tooltip info, click on the PolyPhen-2 prediction(score) checkbox to display the PolyPhen-2 prediction and score column in the results table    tooltip info, click on the Interface(source RCSB) checkbox to display the Interface column in the results table    tooltip info, click on the Pfam domain checkbox to display the Pfam domain id column in the results table    tooltip info, click on the Location (GRCh37) checkbox to display the column containing the GRCh37 Chromosome location in the results table    tooltip info, click on the Location (GRCh38) checkbox to display the column containing the GRCh38 Chromosome location in the results table    tooltip info, click on the CCR percentile checkbox to display the conserved coding region percentile column in the results table    tooltip info, click on the GERP score checkbox to display the GERP score column in the results table

If your variant is not present in the table below click here to use our missense3d website to analyse it using your own 3D structural model.

Download Report Uniprot Position PDB/Model Position Residue Wildtype Residue Mutant Structure Structure Type Missense3D Prediction Structural damage predicted Humsavar Annotation ClinVar Annotation MAF score dbSNP Ensemble ID SIFT prediction(score) PolyPhen-2 prediction(score) Interface(source RCSB) Pfam domain Location (GRCh37) Location (GRCh38) CCR percentile GERP score
link to download the report for this variant 152 152 THR MET 1u46_B PDB Neutral none predicted Benign - 3.805e-05 rs56161912 ENST00000333602 deleterious(0.02) benign(0.188) - Pkinase_Tyr 3:195611684 3:195884813 64 4.19
link to download the report for this variant 346 346 GLU LYS 1u46_B PDB Neutral none predicted Unclassified - - rs970946035 ENST00000333602 deleterious(0.01) possibly_damaging(0.9) - Pkinase_Tyr 3:195605442 3:195878571 14 5.27
link to download the report for this variant 409 409 MET ILE 4hzs_D PDB Neutral none predicted Unclassified - - - - tolerated(0.13) benign(0.021) - SH3_9 - - - -
link to download the report for this variant 256 256 ARG CYS 1u46_B PDB Neutral none predicted - Not_provided 1.218e-05 rs767408627 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195609043 3:195882172 62 4.88
link to download the report for this variant 363 363 VAL ALA 1u46_B PDB Neutral none predicted - VUS 3.672e-05 rs370013968 ENST00000333602 deleterious(0) probably_damaging(0.993) - Pkinase_Tyr 3:195605390 3:195878519 18 3.96
link to download the report for this variant 115 115 GLN HIS 4hzs_D PDB Neutral none predicted - - - rs1333164994 ENST00000333602 tolerated(0.1) benign(0.001) - - 3:195611794 3:195884923 6 4.05
link to download the report for this variant 115 115 GLN GLU 4hzs_D PDB Neutral none predicted - - 4.07e-06 rs769966957 ENST00000333602 tolerated(0.18) benign(0.003) - - 3:195611796 3:195884925 6 4.92
link to download the report for this variant 116 116 SER GLY 4hzs_D PDB Neutral none predicted - - 4.07e-06 rs762088785 ENST00000333602 tolerated(0.07) benign(0) - - 3:195611793 3:195884922 6 4.92
link to download the report for this variant 116 116 SER ILE 4hzs_D PDB Neutral none predicted - - 4.071e-06 rs776926100 ENST00000333602 deleterious(0) benign(0) - - 3:195611792 3:195884921 0 4.92
link to download the report for this variant 118 118 THR PRO 1u46_B PDB Damaging Disallowed phi/psi - - 4.907e-05 rs747047174 ENST00000333602 tolerated(0.08) benign(0.287) Yes - 3:195611787 3:195884916 23 3.74
link to download the report for this variant 118 118 THR SER 1u46_B PDB Neutral none predicted - - 4.069e-06 rs776174518 ENST00000333602 deleterious(0.03) benign(0.031) Yes - 3:195611786 3:195884915 23 4.92
link to download the report for this variant 121 121 ILE THR 1u46_B PDB Neutral none predicted - - 2.034e-05 rs746278409 ENST00000333602 deleterious(0) possibly_damaging(0.547) - - 3:195611777 3:195884906 0 4.92
link to download the report for this variant 121 121 ILE VAL 1u46_B PDB Neutral none predicted - - 2.035e-05 rs1039593880 ENST00000333602 deleterious(0.05) benign(0.007) - - 3:195611778 3:195884907 34 4.92
link to download the report for this variant 122 122 GLY ALA 1u46_B PDB Neutral none predicted - - 0.00024 rs55647828 ENST00000333602 tolerated(0.69) benign(0.003) Yes - 3:195611774 3:195884903 6 3.79
link to download the report for this variant 123 123 GLU ALA 1u46_B PDB Neutral none predicted - - 1.22e-05 rs757500864 ENST00000333602 deleterious(0) benign(0.057) Yes - 3:195611771 3:195884900 6 3.76
link to download the report for this variant 124 124 LYS ASN 1u46_B PDB Neutral none predicted - - - - - tolerated(0.08) benign(0.015) Yes - - - - -
link to download the report for this variant 127 127 ARG CYS 1u46_B PDB Neutral none predicted - - 2.035e-05 rs368727352 ENST00000333602 tolerated(0.17) benign(0.007) - Pkinase_Tyr 3:195611760 3:195884889 49 3.91
link to download the report for this variant 127 127 ARG HIS 1u46_B PDB Neutral none predicted - - 8.139e-06 rs1359669661 ENST00000333602 tolerated(0.54) benign(0) - Pkinase_Tyr 3:195611759 3:195884888 0 0.35
link to download the report for this variant 128 128 LEU PHE 1u46_B PDB Neutral none predicted - - 4.069e-06 rs754511166 ENST00000333602 deleterious(0.02) benign(0.44) - Pkinase_Tyr 3:195611757 3:195884886 1 4.03
link to download the report for this variant 131 131 LYS ARG 1u46_B PDB Neutral none predicted - - - rs1049098421 ENST00000333602 tolerated(0.36) benign(0.003) - Pkinase_Tyr 3:195611747 3:195884876 92 4.99
link to download the report for this variant 133 133 GLY VAL 1u46_B PDB Neutral none predicted - - - rs1433188046 ENST00000333602 deleterious(0) possibly_damaging(0.859) - Pkinase_Tyr 3:195611741 3:195884870 92 4.99
link to download the report for this variant 135 135 GLY VAL 1u4d_B PDB Neutral none predicted - - - rs1338908388 ENST00000333602 deleterious(0) possibly_damaging(0.795) - Pkinase_Tyr 3:195611735 3:195884864 92 4.84
link to download the report for this variant 135 135 GLY SER 1u4d_B PDB Neutral none predicted - - - - - deleterious(0) benign(0.397) - Pkinase_Tyr - - - -
link to download the report for this variant 135 135 GLY ASP 1u4d_B PDB Neutral none predicted - - - - - deleterious(0) benign(0.047) - Pkinase_Tyr - - - -
link to download the report for this variant 139 139 VAL MET 1u46_B PDB Neutral none predicted - - 4.082e-05 rs762933162 ENST00000333602 deleterious(0) possibly_damaging(0.537) - Pkinase_Tyr 3:195611724 3:195884853 92 4.99
link to download the report for this variant 140 140 VAL ALA 1u46_B PDB Neutral none predicted - - 1.226e-05 rs765083803 ENST00000333602 deleterious(0) benign(0.183) - Pkinase_Tyr 3:195611720 3:195884849 11 4.99
link to download the report for this variant 141 141 ARG HIS 1u46_B PDB Neutral none predicted - - 8.188e-06 rs768970594 ENST00000333602 tolerated(0.09) benign(0.432) - Pkinase_Tyr 3:195611717 3:195884846 0 5.12
link to download the report for this variant 141 141 ARG PRO 1u46_B PDB Damaging Disallowed phi/psi; Buried / exposed switch - - 8.188e-06 rs768970594 ENST00000333602 tolerated(0.09) benign(0.432) - Pkinase_Tyr 3:195611717 3:195884846 0 5.12
link to download the report for this variant 141 141 ARG LEU 1u46_B PDB Neutral none predicted - - 8.188e-06 rs768970594 ENST00000333602 tolerated(0.09) benign(0.432) - Pkinase_Tyr 3:195611717 3:195884846 0 5.12
link to download the report for this variant 141 141 ARG CYS 1u46_B PDB Neutral none predicted - - 2.046e-05 rs777025989 ENST00000333602 deleterious(0) possibly_damaging(0.696) - Pkinase_Tyr 3:195611718 3:195884847 1 5.12
link to download the report for this variant 142 142 ARG GLY 1u46_B PDB Neutral none predicted - - - rs1201070236 ENST00000333602 deleterious(0) benign(0.102) - Pkinase_Tyr 3:195611715 3:195884844 1 -3.61
link to download the report for this variant 144 144 GLU LYS 1u46_B PDB Neutral none predicted - - 1.232e-05 rs200819943 ENST00000333602 deleterious(0) benign(0.211) - Pkinase_Tyr 3:195611709 3:195884838 14 4.22
link to download the report for this variant 145 145 TRP CYS 1u46_B PDB Neutral none predicted - - - rs1393460104 ENST00000333602 deleterious(0) probably_damaging(0.971) - Pkinase_Tyr 3:195611704 3:195884833 27 5.12
link to download the report for this variant 146 146 ASP ALA 1u46_B PDB Neutral none predicted - - 4.119e-06 rs772523917 ENST00000333602 tolerated(0.85) benign(0.005) - Pkinase_Tyr 3:195611702 3:195884831 27 5.12
link to download the report for this variant 147 147 ALA VAL 1u46_B PDB Neutral none predicted - - 6.615e-05 rs771344043 ENST00000333602 tolerated(0.11) benign(0.006) - Pkinase_Tyr 3:195611699 3:195884828 0 5.12
link to download the report for this variant 147 147 ALA THR 1u46_B PDB Neutral none predicted - - 9.09e-05 rs138590895 ENST00000333602 tolerated(1) benign(0.012) - Pkinase_Tyr 3:195611700 3:195884829 1 5.12
link to download the report for this variant 150 150 GLY GLU 1u46_B PDB Damaging Disallowed phi/psi; Gly in a bend - - 0.0 rs370229258 ENST00000333602 deleterious(0.01) benign(0.054) - Pkinase_Tyr 3:195611690 3:195884819 64 3.33
link to download the report for this variant 153 153 VAL ALA 1u46_B PDB Neutral none predicted - - 4.078e-06 rs757947685 ENST00000333602 deleterious(0) benign(0.102) - Pkinase_Tyr 3:195610179 3:195883308 4 5.44
link to download the report for this variant 155 155 VAL MET 1u46_B PDB Neutral none predicted - - 4.075e-06 rs745338899 ENST00000333602 deleterious(0) probably_damaging(0.991) - Pkinase_Tyr 3:195610174 3:195883303 16 5.44
link to download the report for this variant 156 156 ALA THR 1u46_B PDB Neutral none predicted - - 0.0 rs1283331208 ENST00000333602 deleterious(0) probably_damaging(0.994) - Pkinase_Tyr 3:195610171 3:195883300 23 5.44
link to download the report for this variant 156 156 ALA VAL 1u46_B PDB Neutral none predicted - - - rs1054632832 ENST00000333602 deleterious(0) probably_damaging(0.988) - Pkinase_Tyr 3:195610170 3:195883299 23 5.44
link to download the report for this variant 157 157 VAL GLY 1u46_B PDB Neutral none predicted - - - rs778957990 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195610167 3:195883296 0 5.44
link to download the report for this variant 157 157 VAL LEU 1u46_B PDB Neutral none predicted - - 4.074e-06 rs1343277055 ENST00000333602 deleterious(0.01) probably_damaging(0.99) - Pkinase_Tyr 3:195610168 3:195883297 23 5.44
link to download the report for this variant 159 159 CYS ARG 1u46_B PDB Neutral none predicted - - 4.073e-06 rs1299587433 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195610162 3:195883291 23 5.44
link to download the report for this variant 162 162 PRO SER 3eqr_B PDB Neutral none predicted - - - rs954474352 ENST00000333602 tolerated(1) benign(0.018) - Pkinase_Tyr 3:195610153 3:195883282 54 5.44
link to download the report for this variant 162 162 PRO THR 3eqr_B PDB Neutral none predicted - - - rs954474352 ENST00000333602 tolerated(1) benign(0.018) - Pkinase_Tyr 3:195610153 3:195883282 54 5.44
link to download the report for this variant 163 163 ASP GLU 3eqr_B PDB Neutral none predicted - - 3.256e-05 rs370771145 ENST00000333602 deleterious(0.03) benign(0.125) Yes Pkinase_Tyr 3:195610148 3:195883277 1 0.06
link to download the report for this variant 163 163 ASP ASN 3eqr_B PDB Neutral none predicted - - 2.035e-05 rs753750642 ENST00000333602 tolerated(0.16) benign(0.209) Yes Pkinase_Tyr 3:195610150 3:195883279 54 5.44
link to download the report for this variant 165 165 LEU VAL 3eqr_B PDB Neutral none predicted - - 8.14e-06 rs755912029 ENST00000333602 tolerated(0.05) possibly_damaging(0.655) Yes Pkinase_Tyr 3:195610144 3:195883273 11 5.44
link to download the report for this variant 166 166 SER GLY 3eqr_B PDB Neutral none predicted - - 0.0 rs1430123336 ENST00000333602 tolerated(0.07) benign(0.021) - Pkinase_Tyr 3:195610141 3:195883270 16 5.44
link to download the report for this variant 166 166 SER ARG 3eqr_B PDB Neutral none predicted - - 4.07e-06 rs752982509 ENST00000333602 tolerated(0.18) possibly_damaging(0.865) - Pkinase_Tyr 3:195610139 3:195883268 16 3.63
link to download the report for this variant 169 169 GLU ASP 1u46_A PDB Neutral none predicted - - 4.069e-06 rs1265629903 ENST00000333602 tolerated(1) benign(0.003) Yes Pkinase_Tyr 3:195610130 3:195883259 1 3.62
link to download the report for this variant 170 170 ALA VAL 1u46_A PDB Neutral none predicted - - 4.069e-06 rs1194573822 ENST00000333602 tolerated(0.35) benign(0.165) - Pkinase_Tyr 3:195610128 3:195883257 1 5.44
link to download the report for this variant 171 171 MET THR 1u46_B PDB Neutral none predicted - - - rs1455755949 ENST00000333602 deleterious(0.03) possibly_damaging(0.661) Yes Pkinase_Tyr 3:195610125 3:195883254 0 5.44
link to download the report for this variant 171 171 MET VAL 1u46_B PDB Neutral none predicted - - 4.069e-06 rs759706081 ENST00000333602 deleterious(0.03) benign(0.118) Yes Pkinase_Tyr 3:195610126 3:195883255 1 4.21
link to download the report for this variant 172 172 ASP GLU 1u46_B PDB Neutral none predicted - - 4.07e-06 rs55636345 ENST00000333602 tolerated(0.45) benign(0.066) Yes Pkinase_Tyr 3:195610121 3:195883250 16 -8.2
link to download the report for this variant 172 172 ASP ALA 1u46_B PDB Neutral none predicted - - - rs1156927783 ENST00000333602 deleterious(0.02) possibly_damaging(0.755) Yes Pkinase_Tyr 3:195610122 3:195883251 16 5.44
link to download the report for this variant 173 173 ASP ASN 1u46_B PDB Neutral none predicted - - 4.07e-06 rs766970227 ENST00000333602 deleterious(0.01) probably_damaging(1) - Pkinase_Tyr 3:195610120 3:195883249 0 5.44
link to download the report for this variant 175 175 ILE MET 1u46_B PDB Neutral none predicted - - - rs1442148085 ENST00000333602 deleterious(0.01) probably_damaging(0.988) Yes Pkinase_Tyr 3:195610112 3:195883241 40 4.56
link to download the report for this variant 176 176 ARG GLN 1u46_B PDB Neutral none predicted - - - - - tolerated(0.11) possibly_damaging(0.884) Yes Pkinase_Tyr - - - -
link to download the report for this variant 176 176 ARG TRP 1u46_B PDB Neutral none predicted - - 0.0001955 rs184412835 ENST00000333602 deleterious(0.03) probably_damaging(0.992) Yes Pkinase_Tyr 3:195610111 3:195883240 40 5.44
link to download the report for this variant 179 179 ASN TYR 1u46_B PDB Neutral none predicted - - 4.074e-06 rs1320709774 ENST00000333602 deleterious(0) probably_damaging(0.997) Yes Pkinase_Tyr 3:195610102 3:195883231 34 5.44
link to download the report for this variant 181 181 MET THR 1u46_B PDB Neutral none predicted - - 8.154e-06 rs748462985 ENST00000333602 deleterious(0) probably_damaging(0.986) - Pkinase_Tyr 3:195610095 3:195883224 28 5.44
link to download the report for this variant 182 182 HIS TYR 1u46_B PDB Neutral none predicted - - 8.157e-06 rs775248747 ENST00000333602 deleterious(0.05) probably_damaging(0.983) Yes Pkinase_Tyr 3:195610093 3:195883222 1 5.44
link to download the report for this variant 183 183 SER LEU 1u46_B PDB Neutral none predicted - - 8.164e-06 rs377632238 ENST00000333602 deleterious(0) probably_damaging(0.997) Yes Pkinase_Tyr 3:195610089 3:195883218 11 4.56
link to download the report for this variant 183 183 SER TRP 1u46_B PDB Neutral none predicted - - 8.164e-06 rs377632238 ENST00000333602 deleterious(0) probably_damaging(0.997) Yes Pkinase_Tyr 3:195610089 3:195883218 11 4.56
link to download the report for this variant 185 185 ASP ASN 1u46_B PDB Neutral none predicted - - 2.045e-05 rs770496107 ENST00000333602 tolerated(0.21) benign(0.179) - Pkinase_Tyr 3:195610084 3:195883213 16 5.44
link to download the report for this variant 185 185 ASP TYR 1u46_B PDB Neutral none predicted - - 2.045e-05 rs770496107 ENST00000333602 tolerated(0.21) benign(0.179) - Pkinase_Tyr 3:195610084 3:195883213 16 5.44
link to download the report for this variant 187 187 ARG GLN 1u46_B PDB Neutral none predicted - - 1.23e-05 rs756000040 ENST00000333602 tolerated(1) benign(0.037) - Pkinase_Tyr 3:195610077 3:195883206 0 5.44
link to download the report for this variant 188 188 ASN LYS 1u46_B PDB Damaging Buried charge introduced - - 4.1e-06 rs374213988 ENST00000333602 deleterious(0) probably_damaging(0.999) - Pkinase_Tyr 3:195610073 3:195883202 14 3.62
link to download the report for this variant 188 188 ASN SER 1u46_B PDB Neutral none predicted - - - rs994688493 ENST00000333602 deleterious(0) probably_damaging(0.911) - Pkinase_Tyr 3:195610074 3:195883203 14 5.44
link to download the report for this variant 189 189 LEU PHE 1u46_B PDB Neutral none predicted - - - rs1475943349 ENST00000333602 deleterious(0) probably_damaging(0.998) - Pkinase_Tyr 3:195610072 3:195883201 0 4.55
link to download the report for this variant 191 191 ARG GLY 1u46_B PDB Neutral none predicted - - 4.105e-06 rs755144718 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195610066 3:195883195 27 5.44
link to download the report for this variant 191 191 ARG CYS 1u46_B PDB Neutral none predicted - - 4.105e-06 rs755144718 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195610066 3:195883195 27 5.44
link to download the report for this variant 191 191 ARG HIS 1u46_B PDB Neutral none predicted - - 0.0 rs751730320 ENST00000333602 deleterious(0.04) probably_damaging(1) - Pkinase_Tyr 3:195610065 3:195883194 0 5.44
link to download the report for this variant 191 191 ARG PRO 1u46_B PDB Neutral none predicted - - 0.0 rs751730320 ENST00000333602 deleterious(0.04) probably_damaging(1) - Pkinase_Tyr 3:195610065 3:195883194 0 5.44
link to download the report for this variant 192 192 LEU VAL 1u46_B PDB Neutral none predicted - - - rs1416261693 ENST00000333602 deleterious(0) probably_damaging(0.971) - Pkinase_Tyr 3:195610063 3:195883192 20 4.55
link to download the report for this variant 192 192 LEU PRO 1u46_B PDB Damaging Buried Pro introduced - - 0.0 rs1190784644 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195610062 3:195883191 20 5.44
link to download the report for this variant 193 193 TYR CYS 1u46_B PDB Neutral none predicted - - 1.234e-05 rs766453551 ENST00000333602 deleterious(0) probably_damaging(0.996) - Pkinase_Tyr 3:195610059 3:195883188 20 5.44
link to download the report for this variant 194 194 GLY GLU 1u46_B PDB Damaging Buried charge introduced; Buried Gly replaced - - 4.115e-06 rs750951757 ENST00000333602 deleterious(0) probably_damaging(0.999) - Pkinase_Tyr 3:195610056 3:195883185 0 5.44
link to download the report for this variant 195 195 VAL MET 1u46_B PDB Damaging Buried / exposed switch - - 4.118e-06 rs765694038 ENST00000333602 deleterious(0.02) probably_damaging(0.991) - Pkinase_Tyr 3:195610054 3:195883183 1 5.44
link to download the report for this variant 196 196 VAL MET 1u46_B PDB Neutral none predicted - - 0.0 rs1017432613 ENST00000333602 deleterious(0) probably_damaging(0.994) - Pkinase_Tyr 3:195610051 3:195883180 51 5.44
link to download the report for this variant 197 197 LEU PHE 1u46_B PDB Neutral none predicted - - - rs1459113556 ENST00000333602 deleterious(0.01) probably_damaging(0.993) Yes Pkinase_Tyr 3:195610048 3:195883177 51 5.44
link to download the report for this variant 198 198 THR MET 1u46_B PDB Neutral none predicted - - 8.27e-06 rs762213900 ENST00000333602 deleterious(0) possibly_damaging(0.639) Yes Pkinase_Tyr 3:195610044 3:195883173 51 4.57
link to download the report for this variant 199 199 PRO LEU 1u46_B PDB Neutral none predicted - - 1.658e-05 rs759113376 ENST00000333602 tolerated(0.1) benign(0.003) Yes Pkinase_Tyr 3:195610041 3:195883170 51 3.62
link to download the report for this variant 199 199 PRO SER 1u46_B PDB Neutral none predicted - - 4.142e-06 rs771822142 ENST00000333602 tolerated(0.29) benign(0.003) Yes Pkinase_Tyr 3:195610042 3:195883171 51 5.44
link to download the report for this variant 202 202 LYS ASN 1u46_B PDB Damaging Buried salt bridge breakage - - - rs1010614296 ENST00000333602 deleterious(0.01) probably_damaging(0.999) - Pkinase_Tyr 3:195610031 3:195883160 77 3.3
link to download the report for this variant 206 206 GLU GLN 1u46_B PDB Neutral none predicted - - 4.092e-06 rs550978754 ENST00000333602 deleterious(0) probably_damaging(0.999) - Pkinase_Tyr 3:195609193 3:195882322 77 5.41
link to download the report for this variant 206 206 GLU LYS 1u46_B PDB Neutral none predicted - - 4.092e-06 rs550978754 ENST00000333602 deleterious(0) probably_damaging(0.999) - Pkinase_Tyr 3:195609193 3:195882322 77 5.41
link to download the report for this variant 207 207 LEU MET 1u46_B PDB Neutral none predicted - - 1.636e-05 rs1213777596 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195609190 3:195882319 4 5.41
link to download the report for this variant 210 210 LEU GLN 1u46_B PDB Neutral none predicted - - 2.45e-05 rs372035229 ENST00000333602 deleterious(0.01) probably_damaging(0.974) - Pkinase_Tyr 3:195609180 3:195882309 44 5.41
link to download the report for this variant 211 211 GLY GLU 1u46_B PDB Neutral none predicted - - 8.166e-06 rs779055442 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195609177 3:195882306 4 4.53
link to download the report for this variant 212 212 SER LEU 1u46_B PDB Neutral none predicted - - - rs757310380 ENST00000333602 deleterious(0) probably_damaging(0.995) - Pkinase_Tyr 3:195609174 3:195882303 6 5.41
link to download the report for this variant 214 214 LEU SER 1u46_B PDB Neutral none predicted - - 4.076e-06 rs756635191 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195609168 3:195882297 0 5.41
link to download the report for this variant 215 215 ASP GLU 1u46_B PDB Neutral none predicted - - 3.261e-05 rs143587665 ENST00000333602 tolerated(0.09) benign(0.093) - Pkinase_Tyr 3:195609164 3:195882293 1 5.41
link to download the report for this variant 216 216 ARG TRP 1u46_B PDB Neutral none predicted - - 8.153e-06 rs755339346 ENST00000333602 deleterious(0.02) probably_damaging(0.999) - Pkinase_Tyr 3:195609163 3:195882292 0 3.57
link to download the report for this variant 216 216 ARG GLN 1u46_B PDB Neutral none predicted - - 0.0006763 rs199724610 ENST00000333602 deleterious(0.04) probably_damaging(0.986) - Pkinase_Tyr 3:195609162 3:195882291 0 5.41
link to download the report for this variant 218 218 ARG HIS 1u46_B PDB Neutral none predicted - - 1.223e-05 rs764003397 ENST00000333602 deleterious(0.04) probably_damaging(1) - Pkinase_Tyr 3:195609156 3:195882285 0 5.41
link to download the report for this variant 218 218 ARG PRO 1u46_B PDB Neutral none predicted - - 1.223e-05 rs764003397 ENST00000333602 deleterious(0.04) probably_damaging(1) - Pkinase_Tyr 3:195609156 3:195882285 0 5.41
link to download the report for this variant 218 218 ARG CYS 1u46_B PDB Neutral none predicted - - 0.0001108 rs776183972 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195609157 3:195882286 16 5.41
link to download the report for this variant 218 218 ARG SER 1u46_B PDB Neutral none predicted - - 0.0001108 rs776183972 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195609157 3:195882286 16 5.41
link to download the report for this variant 222 222 GLY SER 1u46_B PDB Neutral none predicted - - 4.068e-06 rs1202675063 ENST00000333602 tolerated(0.09) possibly_damaging(0.841) - Pkinase_Tyr 3:195609145 3:195882274 49 4.89
link to download the report for this variant 223 223 HIS LEU 1u46_A PDB Neutral none predicted - - 1.22e-05 rs775346909 ENST00000333602 deleterious(0.02) benign(0.438) - Pkinase_Tyr 3:195609141 3:195882270 11 3.74
link to download the report for this variant 224 224 PHE ILE 1u46_A PDB Neutral none predicted - - 4.066e-06 rs1246390924 ENST00000333602 tolerated(0.82) benign(0.082) - Pkinase_Tyr 3:195609139 3:195882268 1 4.74
link to download the report for this variant 226 226 LEU PRO 1u46_B PDB Neutral none predicted - - - rs1483217741 ENST00000333602 deleterious(0) possibly_damaging(0.703) - Pkinase_Tyr 3:195609132 3:195882261 34 4.74
link to download the report for this variant 228 228 THR SER 1u46_B PDB Neutral none predicted - - - - - tolerated(0.26) benign(0.007) - Pkinase_Tyr - - - -
link to download the report for this variant 229 229 LEU ARG 1u46_B PDB Damaging Buried hydrophilic introduced; Buried charge introduced - - 3.657e-05 rs759284337 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195609123 3:195882252 34 4.74
link to download the report for this variant 231 231 ARG HIS 1u46_B PDB Neutral none predicted - - 4.063e-06 rs540529215 ENST00000333602 tolerated(0.2) benign(0.012) - Pkinase_Tyr 3:195609117 3:195882246 0 4.74
link to download the report for this variant 231 231 ARG CYS 1u46_B PDB Neutral none predicted - - 8.127e-06 rs565283012 ENST00000333602 deleterious(0.05) possibly_damaging(0.908) - Pkinase_Tyr 3:195609118 3:195882247 16 4.74
link to download the report for this variant 233 233 ALA THR 1u46_B PDB Neutral none predicted - - 4.062e-06 rs749390120 ENST00000333602 tolerated(0.07) possibly_damaging(0.773) - Pkinase_Tyr 3:195609112 3:195882241 16 4.74
link to download the report for this variant 234 234 VAL MET 1u46_B PDB Damaging Buried / exposed switch - - - rs1429784562 ENST00000333602 deleterious(0.01) probably_damaging(0.993) - Pkinase_Tyr 3:195609109 3:195882238 58 4.74
link to download the report for this variant 237 237 ALA VAL 1u46_B PDB Neutral none predicted - - 4.062e-06 rs769698485 ENST00000333602 deleterious(0.05) probably_damaging(0.957) - Pkinase_Tyr 3:195609099 3:195882228 58 4.74
link to download the report for this variant 237 237 ALA SER 1u46_B PDB Neutral none predicted - - - - - tolerated(0.09) possibly_damaging(0.738) - Pkinase_Tyr - - - -
link to download the report for this variant 238 238 GLU LYS 1u46_B PDB Neutral none predicted - - 4.062e-06 rs748682309 ENST00000333602 tolerated(0.89) benign(0.018) - Pkinase_Tyr 3:195609097 3:195882226 1 4.74
link to download the report for this variant 242 242 TYR CYS 1u46_B PDB Neutral none predicted - - 4.061e-06 rs781746773 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195609084 3:195882213 58 4.88
link to download the report for this variant 243 243 LEU PRO 1u46_B PDB Damaging Buried Pro introduced - - 4.061e-06 rs375858242 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195609081 3:195882210 6 4.88
link to download the report for this variant 245 245 SER PHE 1u46_B PDB Neutral none predicted - - 1.218e-05 rs751941326 ENST00000333602 deleterious(0) possibly_damaging(0.667) - Pkinase_Tyr 3:195609075 3:195882204 23 4.88
link to download the report for this variant 247 247 ARG CYS 1u46_B PDB Neutral none predicted - - 4.061e-06 rs756928677 ENST00000333602 deleterious(0) probably_damaging(1) Yes Pkinase_Tyr 3:195609070 3:195882199 16 4.88
link to download the report for this variant 247 247 ARG SER 1u46_B PDB Neutral none predicted - - 4.061e-06 rs756928677 ENST00000333602 deleterious(0) probably_damaging(1) Yes Pkinase_Tyr 3:195609070 3:195882199 16 4.88
link to download the report for this variant 247 247 ARG HIS 1u46_B PDB Neutral none predicted - - 6.904e-05 rs148932803 ENST00000333602 deleterious(0.04) probably_damaging(0.999) Yes Pkinase_Tyr 3:195609069 3:195882198 0 4.88
link to download the report for this variant 251 251 ARG HIS 1u46_B PDB Neutral none predicted - - 8.122e-06 rs760128364 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195609057 3:195882186 0 4.88
link to download the report for this variant 251 251 ARG CYS 1u46_B PDB Damaging Buried charge replaced - - 1.218e-05 rs763672113 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195609058 3:195882187 49 4.88
link to download the report for this variant 254 254 ALA GLY 1u46_B PDB Neutral none predicted - - - rs1443565757 ENST00000333602 deleterious(0) probably_damaging(0.998) - Pkinase_Tyr 3:195609048 3:195882177 62 4.88
link to download the report for this variant 254 254 ALA THR 1u46_B PDB Neutral none predicted - - - rs752659975 ENST00000333602 deleterious(0) probably_damaging(0.999) - Pkinase_Tyr 3:195609049 3:195882178 62 4.88
link to download the report for this variant 256 256 ARG HIS 1u46_B PDB Neutral none predicted - - - rs867699975 ENST00000333602 deleterious(0) probably_damaging(0.999) - Pkinase_Tyr 3:195609042 3:195882171 0 4.88
link to download the report for this variant 257 257 ASN SER 1u46_B PDB Neutral none predicted - - 4.061e-06 rs759371915 ENST00000333602 deleterious(0) probably_damaging(0.998) - Pkinase_Tyr 3:195609039 3:195882168 11 4.88
link to download the report for this variant 259 259 LEU PRO 1u46_B PDB Damaging Disallowed phi/psi; Cavity altered - - 4.061e-06 rs1241084314 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195609033 3:195882162 23 4.88
link to download the report for this variant 260 260 LEU VAL 1u46_B PDB Neutral none predicted - - 4.061e-06 rs774178896 ENST00000333602 deleterious(0.02) probably_damaging(0.997) - Pkinase_Tyr 3:195609031 3:195882160 1 -0.02
link to download the report for this variant 261 261 ALA GLY 1u46_B PDB Neutral none predicted - - 4.061e-06 rs763245790 ENST00000333602 deleterious(0.03) possibly_damaging(0.842) - Pkinase_Tyr 3:195609027 3:195882156 11 4.88
link to download the report for this variant 261 261 ALA VAL 1u46_B PDB Neutral none predicted - - 4.061e-06 rs763245790 ENST00000333602 deleterious(0.03) possibly_damaging(0.842) - Pkinase_Tyr 3:195609027 3:195882156 11 4.88
link to download the report for this variant 263 263 ARG CYS 1u46_B PDB Neutral none predicted - - - rs748200070 ENST00000333602 tolerated(0.74) benign(0.038) - Pkinase_Tyr 3:195609022 3:195882151 16 3.97
link to download the report for this variant 263 263 ARG SER 1u46_B PDB Neutral none predicted - - - rs748200070 ENST00000333602 tolerated(0.74) benign(0.038) - Pkinase_Tyr 3:195609022 3:195882151 16 3.97
link to download the report for this variant 263 263 ARG HIS 1u46_B PDB Neutral none predicted - - 2.031e-05 rs781775119 ENST00000333602 tolerated(0.11) possibly_damaging(0.597) - Pkinase_Tyr 3:195609021 3:195882150 0 4.88
link to download the report for this variant 264 264 ASP ASN 1u46_B PDB Neutral none predicted - - - rs1434082281 ENST00000333602 tolerated(0.25) benign(0.029) - Pkinase_Tyr 3:195609019 3:195882148 1 4.88
link to download the report for this variant 265 265 LEU PRO 1u46_B PDB Damaging Disallowed phi/psi - - 4.061e-06 rs747392056 ENST00000333602 tolerated(0.12) probably_damaging(0.944) - Pkinase_Tyr 3:195609015 3:195882144 11 4.88
link to download the report for this variant 267 267 LYS ARG 1u46_B PDB Neutral none predicted - - - rs1395578524 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195609009 3:195882138 49 4.88
link to download the report for this variant 269 269 GLY ARG 1u46_B PDB Damaging Buried Gly replaced; Buried H-bond breakage; Cavity altered; Buried / exposed switch - - 4.061e-06 rs753548814 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195609004 3:195882133 49 4.88
link to download the report for this variant 275 275 ARG GLN 1u46_B PDB Damaging Buried charge replaced - - - - - deleterious(0) probably_damaging(0.999) - Pkinase_Tyr - - - -
link to download the report for this variant 276 276 ALA PRO 1u46_B PDB Neutral none predicted - - 4.062e-06 rs759468401 ENST00000333602 deleterious(0.03) probably_damaging(0.999) - Pkinase_Tyr 3:195608983 3:195882112 1 4.88
link to download the report for this variant 281 281 ASP ASN 1u46_B PDB Neutral none predicted - - - rs1186147763 ENST00000333602 tolerated(0.07) possibly_damaging(0.543) Yes Pkinase_Tyr 3:195608968 3:195882097 84 4.88
link to download the report for this variant 282 282 ASP GLU 1u46_B PDB Neutral none predicted - - - rs1051905867 ENST00000333602 tolerated(0.14) benign(0.06) Yes Pkinase_Tyr 3:195608963 3:195882092 84 3.07
link to download the report for this variant 284 284 TYR HIS 1u46_B PDB Neutral none predicted - - 4.064e-06 rs1283591444 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195608959 3:195882088 84 4.88
link to download the report for this variant 285 285 VAL ILE 1u46_B PDB Neutral none predicted - - - rs765527874 ENST00000333602 tolerated(0.27) benign(0.122) - Pkinase_Tyr 3:195608956 3:195882085 3 4.88
link to download the report for this variant 286 286 MET LEU 1u46_B PDB Neutral none predicted - - 8.133e-06 rs771739935 ENST00000333602 deleterious(0.01) probably_damaging(0.977) - Pkinase_Tyr 3:195608953 3:195882082 3 4.88
link to download the report for this variant 286 286 MET THR 1u46_B PDB Neutral none predicted - - 4.067e-06 rs1298225833 ENST00000333602 deleterious(0) probably_damaging(0.997) - Pkinase_Tyr 3:195608952 3:195882081 0 4.88
link to download the report for this variant 289 289 HIS TYR 1u46_B PDB Neutral none predicted - - 8.139e-06 rs1383078167 ENST00000333602 deleterious(0) probably_damaging(0.935) - Pkinase_Tyr 3:195608944 3:195882073 34 4.88
link to download the report for this variant 290 290 ARG CYS 1u46_B PDB Neutral none predicted - - 2.444e-05 rs762033031 ENST00000333602 deleterious(0) probably_damaging(0.993) - Pkinase_Tyr 3:195608941 3:195882070 6 4.88
link to download the report for this variant 290 290 ARG HIS 1u46_B PDB Neutral none predicted - - 8.15e-06 rs776838071 ENST00000333602 tolerated(0.3) benign(0.079) - Pkinase_Tyr 3:195608940 3:195882069 0 4.88
link to download the report for this variant 292 292 VAL MET 1u46_B PDB Neutral none predicted - - - - - deleterious(0.04) probably_damaging(0.987) - Pkinase_Tyr - - - -
link to download the report for this variant 295 295 ALA THR 1u46_B PDB Neutral none predicted - - 4.099e-06 rs747564793 ENST00000333602 deleterious(0.02) probably_damaging(0.986) - Pkinase_Tyr 3:195608926 3:195882055 62 4.88
link to download the report for this variant 298 298 ALA VAL 1u46_B PDB Neutral none predicted - - 8.156e-06 rs774690219 ENST00000333602 deleterious(0) probably_damaging(0.999) - Pkinase_Tyr 3:195606041 3:195879170 44 5.37
link to download the report for this variant 300 300 GLU LYS 1u46_B PDB Neutral none predicted - - 1.63e-05 rs747816316 ENST00000333602 deleterious(0) probably_damaging(0.999) - Pkinase_Tyr 3:195606036 3:195879165 16 5.37
link to download the report for this variant 303 303 LYS ARG 1u46_B PDB Neutral none predicted - - 1.63e-05 rs371973887 ENST00000333602 tolerated(0.3) probably_damaging(0.998) - Pkinase_Tyr 3:195606026 3:195879155 65 5.37
link to download the report for this variant 305 305 ARG CYS 1u46_B PDB Neutral none predicted - - 8.136e-06 rs780777204 ENST00000333602 deleterious(0) probably_damaging(1) Yes Pkinase_Tyr 3:195606021 3:195879150 65 5.37
link to download the report for this variant 306 306 THR ILE 1u46_B PDB Neutral none predicted - - 4.066e-06 rs1445994216 ENST00000333602 tolerated(0.05) probably_damaging(0.995) - Pkinase_Tyr 3:195606017 3:195879146 0 5.37
link to download the report for this variant 306 306 THR ALA 1u46_B PDB Neutral none predicted - - 4.067e-06 rs746472227 ENST00000333602 tolerated(0.08) possibly_damaging(0.894) - Pkinase_Tyr 3:195606018 3:195879147 6 5.37
link to download the report for this variant 309 309 HIS TYR 1u46_B PDB Neutral none predicted - - 4.066e-06 rs750311507 ENST00000333602 deleterious(0) probably_damaging(0.999) - Pkinase_Tyr 3:195606009 3:195879138 34 5.37
link to download the report for this variant 309 309 HIS ARG 1u46_B PDB Neutral none predicted - - - - - deleterious(0.01) probably_damaging(0.999) - Pkinase_Tyr - - - -
link to download the report for this variant 311 311 SER GLY 1u46_B PDB Neutral none predicted - - 4.065e-06 rs765137093 ENST00000333602 deleterious(0) possibly_damaging(0.9) - Pkinase_Tyr 3:195606003 3:195879132 23 5.37
link to download the report for this variant 316 316 PHE TYR 1u46_B PDB Neutral none predicted - - 4.064e-06 rs1162587603 ENST00000333602 tolerated(0.07) probably_damaging(0.993) - Pkinase_Tyr 3:195605987 3:195879116 23 5.37
link to download the report for this variant 317 317 GLY ARG 1u46_B PDB Damaging Buried charge introduced; Buried Gly replaced - - 4.876e-05 rs752703999 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195605985 3:195879114 1 5.37
link to download the report for this variant 318 318 VAL LEU 1u46_B PDB Neutral none predicted - - - rs1259251188 ENST00000333602 deleterious(0) probably_damaging(0.997) - Pkinase_Tyr 3:195605982 3:195879111 83 5.37
link to download the report for this variant 320 320 LEU VAL 1u46_B PDB Neutral none predicted - - - - - tolerated(0.06) probably_damaging(0.999) - Pkinase_Tyr - - - -
link to download the report for this variant 323 323 MET ILE 1u46_B PDB Neutral none predicted - - - - - tolerated(0.15) possibly_damaging(0.652) - Pkinase_Tyr - - - -
link to download the report for this variant 325 325 THR SER 1u46_B PDB Neutral none predicted - - 4.064e-06 rs759962175 ENST00000333602 tolerated(0.16) probably_damaging(0.934) - Pkinase_Tyr 3:195605960 3:195879089 0 5.37
link to download the report for this variant 326 326 TYR CYS 1u46_B PDB Damaging Cavity altered - - 4.064e-06 rs774784617 ENST00000333602 deleterious(0) probably_damaging(0.987) - Pkinase_Tyr 3:195605957 3:195879086 6 5.37
link to download the report for this variant 327 327 GLY SER 1u46_B PDB Damaging Disallowed phi/psi; Gly in a bend - - 4.064e-06 rs200104049 ENST00000333602 deleterious(0.01) probably_damaging(1) - Pkinase_Tyr 3:195605955 3:195879084 1 5.37
link to download the report for this variant 328 328 GLN LEU 1u46_B PDB Neutral none predicted - - - rs1338808066 ENST00000333602 deleterious(0) probably_damaging(0.966) - Pkinase_Tyr 3:195605951 3:195879080 34 5.37
link to download the report for this variant 329 329 GLU LYS 1u46_B PDB Neutral none predicted - - - rs1430068939 ENST00000333602 deleterious(0) probably_damaging(0.981) - Pkinase_Tyr 3:195605949 3:195879078 34 5.37
link to download the report for this variant 329 329 GLU ASP 1u46_B PDB Neutral none predicted - - 8.129e-06 rs145559327 ENST00000333602 tolerated(0.12) benign(0.22) - Pkinase_Tyr 3:195605947 3:195879076 34 5.37
link to download the report for this variant 331 331 TRP CYS 1u46_B PDB Neutral none predicted - - - rs1341590742 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195605941 3:195879070 45 5.37
link to download the report for this variant 332 332 ILE SER 1u46_B PDB Neutral none predicted - - - rs965317967 ENST00000333602 deleterious(0.04) probably_damaging(0.947) - Pkinase_Tyr 3:195605939 3:195879068 45 5.37
link to download the report for this variant 332 332 ILE VAL 1u46_B PDB Neutral none predicted - - - - - tolerated(0.33) benign(0.087) - Pkinase_Tyr - - - -
link to download the report for this variant 333 333 GLY SER 1u46_B PDB Neutral none predicted - - 1.22e-05 rs768172893 ENST00000333602 deleterious(0.02) probably_damaging(0.938) - Pkinase_Tyr 3:195605937 3:195879066 45 5.37
link to download the report for this variant 335 335 ASN LYS 1u46_B PDB Neutral none predicted - - 4.069e-06 rs55701110 ENST00000333602 deleterious(0.01) probably_damaging(1) Yes Pkinase_Tyr 3:195605929 3:195879058 0 1.59
link to download the report for this variant 335 335 ASN SER 1u46_B PDB Neutral none predicted - - 4.068e-06 rs1322872022 ENST00000333602 tolerated(0.23) probably_damaging(0.993) Yes Pkinase_Tyr 3:195605930 3:195879059 28 5.37
link to download the report for this variant 336 336 GLY SER 1u46_B PDB Neutral none predicted - - 8.137e-06 rs1410021195 ENST00000333602 deleterious(0) probably_damaging(1) Yes Pkinase_Tyr 3:195605928 3:195879057 1 5.37
link to download the report for this variant 342 342 LYS ARG 1u46_B PDB Neutral none predicted - - 4.143e-06 rs752888000 ENST00000333602 tolerated(0.16) probably_damaging(0.999) - Pkinase_Tyr 3:195605453 3:195878582 14 5.27
link to download the report for this variant 342 342 LYS GLU 1u46_B PDB Neutral none predicted - - 4.143e-06 rs200412744 ENST00000333602 deleterious(0) probably_damaging(0.999) - Pkinase_Tyr 3:195605454 3:195878583 14 5.27
link to download the report for this variant 343 343 ILE VAL 1u46_B PDB Neutral none predicted - - - rs781438547 ENST00000333602 tolerated(0.43) benign(0.351) - Pkinase_Tyr 3:195605451 3:195878580 18 5.27
link to download the report for this variant 344 344 ASP ASN 1u46_B PDB Neutral none predicted - - - rs1221920695 ENST00000333602 deleterious(0) probably_damaging(0.99) - Pkinase_Tyr 3:195605448 3:195878577 18 5.27
link to download the report for this variant 345 345 LYS ARG 1u46_B PDB Neutral none predicted - - 4.134e-06 rs369579729 ENST00000333602 tolerated(0.59) benign(0.157) Yes Pkinase_Tyr 3:195605444 3:195878573 0 4.11
link to download the report for this variant 345 345 LYS GLN 1u46_B PDB Neutral none predicted - - 8.268e-06 rs373491945 ENST00000333602 tolerated(0.15) benign(0.241) Yes Pkinase_Tyr 3:195605445 3:195878574 18 5.27
link to download the report for this variant 345 345 LYS GLU 1u46_B PDB Neutral none predicted - - 8.268e-06 rs373491945 ENST00000333602 tolerated(0.15) benign(0.241) Yes Pkinase_Tyr 3:195605445 3:195878574 18 5.27
link to download the report for this variant 346 346 GLU ASP 1u46_B PDB Neutral none predicted - - 0.0002188 rs151330438 ENST00000333602 tolerated(0.1) benign(0.039) - Pkinase_Tyr 3:195605440 3:195878569 14 -0.91
link to download the report for this variant 347 347 GLY TRP 1u46_B PDB Neutral none predicted - - 4.127e-06 rs750876936 ENST00000333602 deleterious(0.03) probably_damaging(0.996) - Pkinase_Tyr 3:195605439 3:195878568 0 4.4
link to download the report for this variant 347 347 GLY ARG 1u46_B PDB Neutral none predicted - - 4.127e-06 rs750876936 ENST00000333602 deleterious(0.03) probably_damaging(0.996) - Pkinase_Tyr 3:195605439 3:195878568 0 4.4
link to download the report for this variant 349 349 ARG TRP 1u46_B PDB Neutral none predicted - - 1.649e-05 rs762196782 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195605433 3:195878562 20 3.32
link to download the report for this variant 349 349 ARG GLN 1u46_B PDB Neutral none predicted - - 1.236e-05 rs775043034 ENST00000333602 deleterious(0.01) probably_damaging(0.999) - Pkinase_Tyr 3:195605432 3:195878561 0 3.44
link to download the report for this variant 350 350 LEU PRO 1u46_B PDB Damaging Buried Pro introduced - - 4.118e-06 rs767176473 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195605429 3:195878558 4 5.06
link to download the report for this variant 351 351 PRO ALA 1u46_B PDB Neutral none predicted - - 4.152e-06 rs759173529 ENST00000333602 tolerated(0.25) possibly_damaging(0.752) - Pkinase_Tyr 3:195605427 3:195878556 1 5.06
link to download the report for this variant 351 351 PRO SER 1u46_B PDB Neutral none predicted - - 4.152e-06 rs759173529 ENST00000333602 tolerated(0.25) possibly_damaging(0.752) - Pkinase_Tyr 3:195605427 3:195878556 1 5.06
link to download the report for this variant 351 351 PRO THR 1u46_B PDB Neutral none predicted - - 4.152e-06 rs759173529 ENST00000333602 tolerated(0.25) possibly_damaging(0.752) - Pkinase_Tyr 3:195605427 3:195878556 1 5.06
link to download the report for this variant 352 352 ARG TRP 1u46_B PDB Neutral none predicted - - - rs1418694748 ENST00000333602 deleterious(0) probably_damaging(0.984) - Pkinase_Tyr 3:195605424 3:195878553 26 4.16
link to download the report for this variant 354 354 GLU LYS 1u46_B PDB Neutral none predicted - - 4.108e-06 rs770494199 ENST00000333602 deleterious(0.01) probably_damaging(0.923) - Pkinase_Tyr 3:195605418 3:195878547 26 4.91
link to download the report for this variant 355 355 ASP GLU 1u46_B PDB Neutral none predicted - - 4.1e-06 rs749249077 ENST00000333602 deleterious(0.01) possibly_damaging(0.89) - Pkinase_Tyr 3:195605413 3:195878542 14 4.24
link to download the report for this variant 355 355 ASP ASN 1u46_B PDB Neutral none predicted - - - - - tolerated(0.28) possibly_damaging(0.507) - Pkinase_Tyr - - - -
link to download the report for this variant 356 356 CYS SER 1u46_B PDB Neutral none predicted - - - rs996493288 ENST00000333602 deleterious(0.03) probably_damaging(0.953) - Pkinase_Tyr 3:195605412 3:195878541 0 5.12
link to download the report for this variant 360 360 ILE MET 1u46_B PDB Damaging Buried H-bond breakage - - 4.085e-06 rs1316987163 ENST00000333602 tolerated(0.06) possibly_damaging(0.667) - Pkinase_Tyr 3:195605398 3:195878527 64 3.28
link to download the report for this variant 365 365 VAL PHE 1u46_B PDB Neutral none predicted - - 4.078e-06 rs1300770750 ENST00000333602 deleterious(0) benign(0.135) - Pkinase_Tyr 3:195605385 3:195878514 16 5.12
link to download the report for this variant 370 370 HIS TYR 1u46_B PDB Neutral none predicted - - 4.072e-06 rs1428155517 ENST00000333602 tolerated(1) benign(0.053) - Pkinase_Tyr 3:195605370 3:195878499 16 5.12
link to download the report for this variant 370 370 HIS GLN 1u46_B PDB Neutral none predicted - - - rs755180846 ENST00000333602 tolerated(0.43) benign(0.021) - Pkinase_Tyr 3:195605368 3:195878497 23 3.07
link to download the report for this variant 372 372 PRO ALA 1u46_B PDB Neutral none predicted - - 4.07e-06 rs1164768601 ENST00000333602 deleterious(0.02) probably_damaging(0.999) - Pkinase_Tyr 3:195605364 3:195878493 23 3.96
link to download the report for this variant 375 375 ARG SER 1u46_B PDB Neutral none predicted - - 4.067e-06 rs200483577 ENST00000333602 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195605353 3:195878482 49 0.99
link to download the report for this variant 377 377 THR LYS 1u46_B PDB Neutral none predicted - - 4.066e-06 rs376442586 ENST00000333602 deleterious(0.02) probably_damaging(0.953) - Pkinase_Tyr 3:195605348 3:195878477 16 3.95
link to download the report for this variant 377 377 THR MET 1u46_B PDB Neutral none predicted - - 4.066e-06 rs376442586 ENST00000333602 deleterious(0.02) probably_damaging(0.953) - Pkinase_Tyr 3:195605348 3:195878477 16 3.95
link to download the report for this variant 380 380 ALA THR 1u46_B PDB Neutral none predicted - - - - - tolerated(0.11) probably_damaging(0.945) - Pkinase_Tyr - - - -
link to download the report for this variant 382 382 ARG TRP 1u46_B PDB Neutral none predicted - - 4.064e-06 rs141404332 ENST00000333602 deleterious(0) probably_damaging(0.998) - Pkinase_Tyr 3:195605334 3:195878463 62 3.03
link to download the report for this variant 383 383 ASP TYR 1u46_B PDB Neutral none predicted - - 4.063e-06 rs1481947428 ENST00000333602 deleterious(0) probably_damaging(0.964) - Pkinase_Tyr 3:195605331 3:195878460 6 4.86
link to download the report for this variant 384 384 PHE LEU 1u46_B PDB Neutral none predicted - - 8.125e-06 rs1293932868 ENST00000333602 tolerated(0.16) benign(0.1) - Pkinase_Tyr 3:195605326 3:195878455 16 3.98
link to download the report for this variant 388 388 ALA VAL 1u46_B PDB Neutral none predicted - - 4.061e-06 rs749939902 ENST00000333602 tolerated(0.2) benign(0.221) - - 3:195605217 3:195878346 49 4.47
link to download the report for this variant 390 390 PRO SER 1u46_B PDB Neutral none predicted - - - rs1209265078 ENST00000333602 deleterious(0.02) probably_damaging(0.997) - - 3:195605212 3:195878341 62 4.47
link to download the report for this variant 393 393 MET LEU 4hzs_D PDB Neutral none predicted - - 4.061e-06 rs765154750 ENST00000333602 tolerated(0.1) benign(0.063) - - 3:195605203 3:195878332 62 4.47
link to download the report for this variant 394 394 ARG TRP 4hzs_D PDB Neutral none predicted - - 4.061e-06 rs761815054 ENST00000333602 deleterious(0) probably_damaging(0.958) - - 3:195605200 3:195878329 6 1.45
link to download the report for this variant 394 394 ARG GLN 4hzs_D PDB Neutral none predicted - - 4.061e-06 rs776494851 ENST00000333602 tolerated(0.14) possibly_damaging(0.775) - - 3:195605199 3:195878328 0 4.47
link to download the report for this variant 397 397 GLN GLU 4hzs_D PDB Neutral none predicted - - 4.061e-06 rs1457888475 ENST00000333602 tolerated(0.08) benign(0.026) - SH3_9 3:195605191 3:195878320 34 4.47
link to download the report for this variant 397 397 GLN ARG 4hzs_D PDB Neutral none predicted - - 8.121e-06 rs768463774 ENST00000333602 tolerated(0.29) possibly_damaging(0.503) - SH3_9 3:195605190 3:195878319 0 4.47
link to download the report for this variant 402 402 PRO LEU 4hzs_D PDB Neutral none predicted - - 2.842e-05 rs148791867 ENST00000333602 deleterious(0.04) probably_damaging(0.929) - SH3_9 3:195605175 3:195878304 65 4.47
link to download the report for this variant 403 403 ASP GLU 4hzs_D PDB Neutral none predicted - - 4.061e-06 rs772268617 ENST00000333602 tolerated(0.1) probably_damaging(0.937) - SH3_9 3:195605171 3:195878300 1 3.58
link to download the report for this variant 403 403 ASP ASN 4hzs_D PDB Neutral none predicted - - 8.121e-06 rs1199323322 ENST00000333602 tolerated(0.09) probably_damaging(0.972) - SH3_9 3:195605173 3:195878302 1 4.47
link to download the report for this variant 406 406 HIS ARG 4hzs_D PDB Neutral none predicted - - - rs1185846124 ENST00000333602 tolerated(0.37) benign(0.218) - SH3_9 3:195605163 3:195878292 78 4.47
link to download the report for this variant 407 407 ILE VAL 4hzs_D PDB Neutral none predicted - - - rs1420217152 ENST00000333602 tolerated(0.13) benign(0.243) - SH3_9 3:195605161 3:195878290 78 4.47
link to download the report for this variant 408 408 GLN ARG 4hzs_D PDB Neutral none predicted - - - rs1431363387 ENST00000333602 deleterious(0.02) benign(0.298) - SH3_9 3:195605157 3:195878286 78 4.47
link to download the report for this variant 409 409 MET LEU 4hzs_D PDB Neutral none predicted - - - rs1171575832 ENST00000333602 tolerated(0.21) benign(0.003) - SH3_9 3:195605155 3:195878284 78 4.47
link to download the report for this variant 411 411 ASP VAL 4hzs_D PDB Neutral none predicted - - 4.061e-06 rs1188193080 ENST00000333602 deleterious(0) probably_damaging(0.991) - SH3_9 3:195605148 3:195878277 1 4.47
link to download the report for this variant 415 415 VAL ILE 4hzs_D PDB Neutral none predicted - - 4.061e-06 rs1325257065 ENST00000333602 tolerated(0.91) benign(0) - SH3_9 3:195605137 3:195878266 49 3.6
link to download the report for this variant 415 415 VAL GLY 4hzs_D PDB Neutral none predicted - - 4.061e-06 rs778382280 ENST00000333602 deleterious(0) benign(0.386) - SH3_9 3:195605136 3:195878265 0 4.47
link to download the report for this variant 422 422 ASN TYR 4hzs_D PDB Neutral none predicted - - 8.753e-06 rs772897441 ENST00000333602 tolerated(0.44) probably_damaging(0.945) - SH3_9 3:195599334 3:195872463 26 5.12
link to download the report for this variant 422 422 ASN LYS 4hzs_D PDB Neutral none predicted - - 2.168e-05 rs145954545 ENST00000333602 tolerated(0.12) possibly_damaging(0.905) - SH3_9 3:195599332 3:195872461 1 0.7
link to download the report for this variant 423 423 TYR CYS 4hzs_D PDB Neutral none predicted - - 4.306e-06 rs1464956309 ENST00000333602 deleterious(0.02) probably_damaging(0.999) - SH3_9 3:195599330 3:195872459 1 5.12
link to download the report for this variant 426 426 ARG HIS 4hzs_D PDB Neutral none predicted - - 1.696e-05 rs369790528 ENST00000333602 deleterious(0) probably_damaging(0.998) - SH3_9 3:195599321 3:195872450 37 5.12
link to download the report for this variant 426 426 ARG SER 4hzs_D PDB Neutral none predicted - - 4.255e-06 rs1202967022 ENST00000333602 deleterious(0) probably_damaging(0.995) - SH3_9 3:195599322 3:195872451 37 5.12
link to download the report for this variant 426 426 ARG CYS 4hzs_D PDB Neutral none predicted - - - - - deleterious(0) probably_damaging(0.998) - SH3_9 - - - -
link to download the report for this variant 429 429 ASN SER 4hzs_D PDB Neutral none predicted - - 4.169e-06 rs1256973384 ENST00000333602 deleterious(0.03) possibly_damaging(0.822) - SH3_9 3:195599312 3:195872441 37 5.12
link to download the report for this variant 431 431 ARG TRP 4hzs_D PDB Neutral none predicted - - 0.0 rs139128052 ENST00000333602 deleterious(0) probably_damaging(0.977) - SH3_9 3:195599307 3:195872436 14 4.16
link to download the report for this variant 431 431 ARG GLN 4hzs_D PDB Neutral none predicted - - - rs1211303089 ENST00000333602 deleterious(0.04) benign(0.142) - SH3_9 3:195599306 3:195872435 0 5.45
link to download the report for this variant 433 433 LEU PRO 4hzs_D PDB Damaging Disallowed phi/psi - - - rs1256178343 ENST00000333602 deleterious(0) probably_damaging(0.987) - SH3_9 3:195599300 3:195872429 26 5.45
link to download the report for this variant 434 434 CYS ARG 4hzs_D PDB Neutral none predicted - - 4.115e-06 rs1229303254 ENST00000333602 tolerated(0.55) benign(0.006) - SH3_9 3:195599298 3:195872427 26 4.3
link to download the report for this variant 436 436 GLY GLU 4hzs_D PDB Damaging Disallowed phi/psi; Buried Gly replaced; Buried / exposed switch - - 4.097e-06 rs1364521091 ENST00000333602 deleterious(0) probably_damaging(0.989) - SH3_9 3:195599291 3:195872420 69 5.45
link to download the report for this variant 437 437 PRO LEU 4hzs_D PDB Neutral none predicted - - - rs746946667 ENST00000333602 tolerated(0.7) benign(0.052) - SH3_9 3:195599288 3:195872417 69 5.45
link to download the report for this variant 438 438 PHE LEU 4hzs_D PDB Neutral none predicted - - - rs1206253815 ENST00000333602 deleterious(0.02) probably_damaging(0.993) - SH3_9 3:195599286 3:195872415 69 5.45
link to download the report for this variant 439 439 PRO ARG 4hzs_D PDB Damaging Buried / exposed switch - - 4.086e-06 rs780099540 ENST00000333602 deleterious(0.01) probably_damaging(0.926) - SH3_9 3:195599282 3:195872411 69 5.45
link to download the report for this variant 439 439 PRO LEU 4hzs_D PDB Neutral none predicted - - 4.086e-06 rs780099540 ENST00000333602 deleterious(0.01) probably_damaging(0.926) - SH3_9 3:195599282 3:195872411 69 5.45
link to download the report for this variant 440 440 ARG CYS 4hzs_D PDB Neutral none predicted - - 8.169e-06 rs1403122471 ENST00000333602 deleterious(0) probably_damaging(0.999) - SH3_9 3:195599280 3:195872409 1 4.49
link to download the report for this variant 440 440 ARG HIS 4hzs_D PDB Neutral none predicted - - 4.086e-06 rs988895408 ENST00000333602 deleterious(0) probably_damaging(0.999) - SH3_9 3:195599279 3:195872408 0 5.45
link to download the report for this variant 442 442 VAL MET 4hzs_D PDB Damaging Buried / exposed switch - - 4.082e-06 rs1393270307 ENST00000333602 deleterious(0.01) possibly_damaging(0.549) - SH3_9 3:195599274 3:195872403 16 5.45
link to download the report for this variant 442 442 VAL ALA 4hzs_D PDB Neutral none predicted - - 4.081e-06 rs1170403007 ENST00000333602 tolerated(0.11) benign(0.003) - SH3_9 3:195599273 3:195872402 0 4.31
link to download the report for this variant 444 444 THR ILE 4hzs_D PDB Neutral none predicted - - 8.158e-06 rs750250778 ENST00000333602 deleterious(0.02) possibly_damaging(0.738) - SH3_9 3:195599267 3:195872396 23 5.45
link to download the report for this variant 448 504 GLY SER 1cf4_B PDB Damaging Disallowed phi/psi - - 1.223e-05 rs760763690 ENST00000333602 tolerated(0.07) probably_damaging(0.999) - GTPase_binding 3:195599256 3:195872385 23 5.45
link to download the report for this variant 448 504 GLY ASP 1cf4_B PDB Damaging Disallowed phi/psi - - - - - tolerated(0.06) probably_damaging(0.999) - GTPase_binding - - - -
link to download the report for this variant 450 506 SER LEU 1cf4_B PDB Neutral none predicted - - 0.0001999 rs201070008 ENST00000333602 deleterious(0) probably_damaging(0.981) - GTPase_binding 3:195599249 3:195872378 28 5.45
link to download the report for this variant 453 509 ASP GLU 1cf4_B PDB Neutral none predicted - - 4.077e-06 rs766664708 ENST00000333602 deleterious(0.01) probably_damaging(0.999) - GTPase_binding 3:195599239 3:195872368 0 5.45
link to download the report for this variant 456 512 GLN LYS 1cf4_B PDB Neutral none predicted - - 4.076e-06 rs1312277143 ENST00000333602 tolerated(0.35) benign(0.179) - GTPase_binding 3:195599232 3:195872361 28 5.45
link to download the report for this variant 460 516 ASN LYS 1cf4_B PDB Neutral none predicted - - 0.0002 rs201981998 ENST00000333602 deleterious(0.01) probably_damaging(0.935) - GTPase_binding 3:195599218 3:195872347 95 -7.63
link to download the report for this variant 460 516 ASN SER 1cf4_B PDB Neutral none predicted - - - - - deleterious(0.02) possibly_damaging(0.872) - GTPase_binding - - - -
link to download the report for this variant 469 525 ASP ASN 1cf4_B PDB Neutral none predicted - - 1.634e-05 rs746500207 ENST00000333602 deleterious(0.02) probably_damaging(0.989) - GTPase_binding 3:195599193 3:195872322 95 5.45
link to download the report for this variant 470 526 SER GLY 1cf4_B PDB Neutral none predicted - - - rs1223736093 ENST00000333602 tolerated(0.06) benign(0.194) - GTPase_binding 3:195599190 3:195872319 53 5.45
link to download the report for this variant 470 526 SER ASN 1cf4_B PDB Neutral none predicted - - - rs1226126359 ENST00000333602 deleterious(0.02) possibly_damaging(0.831) - GTPase_binding 3:195599189 3:195872318 53 5.45
link to download the report for this variant 471 527 ASP ALA 1cf4_B PDB Neutral none predicted - - 0.002055 rs200985709 ENST00000333602 tolerated(0.12) possibly_damaging(0.803) - GTPase_binding 3:195599186 3:195872315 53 5.45
link to download the report for this variant 472 528 PRO SER 1cf4_B PDB Neutral none predicted - - - rs1329188399 ENST00000333602 deleterious(0.04) probably_damaging(0.993) - GTPase_binding 3:195599184 3:195872313 53 5.45
link to download the report for this variant 473 529 ARG CYS 1cf4_B PDB Neutral none predicted - - 4.087e-05 rs548592570 ENST00000333602 deleterious(0.02) probably_damaging(0.971) - GTPase_binding 3:195599181 3:195872310 53 5.45
link to download the report for this variant 473 529 ARG HIS 1cf4_B PDB Neutral none predicted - - 6.545e-05 rs566778334 ENST00000333602 tolerated(0.78) benign(0.084) - GTPase_binding 3:195599180 3:195872309 0 5.45
link to download the report for this variant 474 530 HIS ASN 1cf4_B PDB Neutral none predicted - - 4.09e-06 rs376221693 ENST00000333602 tolerated(0.11) possibly_damaging(0.534) - GTPase_binding 3:195599178 3:195872307 1 5.45
link to download the report for this variant 474 530 HIS TYR 1cf4_B PDB Neutral none predicted - - 4.09e-06 rs376221693 ENST00000333602 tolerated(0.11) possibly_damaging(0.534) - GTPase_binding 3:195599178 3:195872307 1 5.45
link to download the report for this variant 474 530 HIS ARG 1cf4_B PDB Neutral none predicted - - 4.092e-06 rs778860799 ENST00000333602 tolerated(1) benign(0.012) - GTPase_binding 3:195599177 3:195872306 0 5.45
link to download the report for this variant 475 531 CYS PHE 1cf4_B PDB Neutral none predicted - - - rs757024520 ENST00000333602 tolerated(0.83) benign(0.097) - GTPase_binding 3:195599174 3:195872303 11 5.45
link to download the report for this variant 475 531 CYS SER 1cf4_B PDB Neutral none predicted - - - rs757024520 ENST00000333602 tolerated(0.83) benign(0.097) - GTPase_binding 3:195599174 3:195872303 11 5.45
link to download the report for this variant 479 535 PRO LEU 1cf4_B PDB Neutral none predicted - - 1.224e-05 rs749498750 ENST00000333602 deleterious(0) probably_damaging(0.933) - GTPase_binding 3:195599162 3:195872291 0 5.45
link to download the report for this variant 479 535 PRO SER 1cf4_B PDB Neutral none predicted - - 8.163e-06 rs1271424037 ENST00000333602 deleterious(0.03) probably_damaging(0.93) - GTPase_binding 3:195599163 3:195872292 49 5.45
link to download the report for this variant 481 537 ARG SER 1cf4_B PDB Neutral none predicted - - - - - deleterious(0.02) benign(0.16) - GTPase_binding - - - -
link to download the report for this variant 483 539 ASP GLU 1cf4_B PDB Neutral none predicted - - 4.087e-06 rs200116122 ENST00000333602 deleterious(0.04) probably_damaging(0.999) - GTPase_binding 3:195599149 3:195872278 58 -10.1
link to download the report for this variant 483 539 ASP ASN 1cf4_B PDB Neutral none predicted - - - - - deleterious(0) probably_damaging(1) - GTPase_binding - - - -
link to download the report for this variant 484 540 GLU LYS 1cf4_B PDB Neutral none predicted - - 2.452e-05 rs755481543 ENST00000333602 deleterious(0.03) possibly_damaging(0.488) - GTPase_binding 3:195599148 3:195872277 0 5.45
link to download the report for this variant 485 541 LEU GLN 1cf4_B PDB Neutral none predicted - - 9.262e-06 rs1250794123 ENST00000333602 deleterious(0) probably_damaging(0.993) - GTPase_binding 3:195597074 3:195870203 13 5.09
link to download the report for this variant 809 809 SER ARG 4ZJV_C MODEL Neutral none predicted - - 5.625e-06 rs570333707 ENST00000333602 deleterious(0.03) possibly_damaging(0.848) - Inhibitor_Mig-6 3:195594697 3:195867826 31 3.36
link to download the report for this variant 809 809 SER GLY 4ZJV_C MODEL Neutral none predicted - - - rs1033597707 ENST00000333602 tolerated(0.14) possibly_damaging(0.535) - Inhibitor_Mig-6 3:195594699 3:195867828 31 4.23
link to download the report for this variant 810 810 SER LEU 4ZJV_D MODEL Neutral none predicted - - 5.625e-06 rs775291990 ENST00000333602 tolerated(0.05) probably_damaging(0.991) - Inhibitor_Mig-6 3:195594695 3:195867824 0 4.37
link to download the report for this variant 811 811 PRO HIS 4ZJV_D MODEL Neutral none predicted - - - - - deleterious_low_confidence(0) probably_damaging(0.999) - Inhibitor_Mig-6 - - - -
link to download the report for this variant 814 814 THR SER 4ZJV_D MODEL Neutral none predicted - - 5.336e-06 rs759528275 ENST00000333602 tolerated(0.75) benign(0.038) - Inhibitor_Mig-6 3:195594684 3:195867813 37 0.54
link to download the report for this variant 815 815 MET ILE 4ZJV_D MODEL Neutral none predicted - - 5.336e-06 rs372158232 ENST00000333602 deleterious(0.03) benign(0.301) - Inhibitor_Mig-6 3:195594679 3:195867808 60 3.47
link to download the report for this variant 815 815 MET THR 4ZJV_D MODEL Neutral none predicted - - 5.246e-06 rs770465067 ENST00000333602 deleterious(0.02) benign(0.237) - Inhibitor_Mig-6 3:195594680 3:195867809 60 4.36
link to download the report for this variant 816 816 PRO SER 4ZJV_D MODEL Neutral none predicted - - 1.049e-05 rs748800592 ENST00000333602 tolerated(0.11) possibly_damaging(0.492) - Inhibitor_Mig-6 3:195594678 3:195867807 60 4.36
link to download the report for this variant 819 819 GLN ARG 4ZJV_D MODEL Neutral none predicted - - 5.049e-06 rs1303086730 ENST00000333602 tolerated(0.12) possibly_damaging(0.446) - Inhibitor_Mig-6 3:195594668 3:195867797 60 4.36
link to download the report for this variant 821 821 PHE SER 4ZJV_D MODEL Neutral none predicted - - 4.892e-06 rs769602863 ENST00000333602 tolerated(0.11) probably_damaging(0.971) - Inhibitor_Mig-6 3:195594662 3:195867791 18 4.36
link to download the report for this variant 822 822 ALA THR 4ZJV_D MODEL Neutral none predicted - - 0.0 rs1404366976 ENST00000333602 deleterious(0.03) benign(0.159) - Inhibitor_Mig-6 3:195594660 3:195867789 3 3.47
link to download the report for this variant 822 822 ALA VAL 4ZJV_D MODEL Neutral none predicted - - 1.95e-05 rs748476187 ENST00000333602 deleterious(0.03) benign(0.224) - Inhibitor_Mig-6 3:195594659 3:195867788 3 3.44
link to download the report for this variant 823 823 SER LEU 4ZJV_D MODEL Neutral none predicted - - 4.831e-06 rs755476319 ENST00000333602 tolerated(0.22) benign(0.412) - Inhibitor_Mig-6 3:195594656 3:195867785 3 4.36
link to download the report for this variant 824 824 ASP VAL 4ZJV_D MODEL Neutral none predicted - - 4.808e-06 rs1191184155 ENST00000333602 deleterious(0) benign(0.265) - Inhibitor_Mig-6 3:195594653 3:195867782 3 4.89
link to download the report for this variant 825 825 PRO ARG 4ZJV_D MODEL Neutral none predicted - - 4.739e-06 rs1425658116 ENST00000333602 deleterious(0) possibly_damaging(0.773) - Inhibitor_Mig-6 3:195594650 3:195867779 3 3.21
link to download the report for this variant 826 826 LYS ASN 4ZJV_D MODEL Neutral none predicted - - 9.403e-06 rs1256907498 ENST00000333602 deleterious(0.04) possibly_damaging(0.575) - Inhibitor_Mig-6 3:195594646 3:195867775 30 4.17
link to download the report for this variant 828 828 ALA SER 4ZJV_D MODEL Neutral none predicted - - 1.876e-05 rs552313951 ENST00000333602 deleterious(0) possibly_damaging(0.851) - Inhibitor_Mig-6 3:195594642 3:195867771 30 5.06
link to download the report for this variant 828 828 ALA PRO 4ZJV_D MODEL Neutral none predicted - - 1.876e-05 rs552313951 ENST00000333602 deleterious(0) possibly_damaging(0.851) - Inhibitor_Mig-6 3:195594642 3:195867771 30 5.06
link to download the report for this variant 828 828 ALA THR 4ZJV_D MODEL Neutral none predicted - - 1.876e-05 rs552313951 ENST00000333602 deleterious(0) possibly_damaging(0.851) - Inhibitor_Mig-6 3:195594642 3:195867771 30 5.06
link to download the report for this variant 829 829 THR ILE 4ZJV_D MODEL Neutral none predicted - - 0.0008397 rs148423089 ENST00000333602 deleterious(0.01) possibly_damaging(0.575) - Inhibitor_Mig-6 3:195594638 3:195867767 8 5.06
link to download the report for this variant 829 829 THR ASN 4ZJV_D MODEL Neutral none predicted - - 0.0008397 rs148423089 ENST00000333602 deleterious(0.01) possibly_damaging(0.575) - Inhibitor_Mig-6 3:195594638 3:195867767 8 5.06
link to download the report for this variant 830 830 PRO SER 4ZJV_D MODEL Neutral none predicted - - - rs1475031162 ENST00000333602 tolerated(0.06) possibly_damaging(0.704) - Inhibitor_Mig-6 3:195594636 3:195867765 3 5.06
link to download the report for this variant 830 830 PRO LEU 4ZJV_D MODEL Neutral none predicted - - 3.666e-05 rs752427250 ENST00000333602 deleterious(0) possibly_damaging(0.819) - Inhibitor_Mig-6 3:195594635 3:195867764 3 5.06
link to download the report for this variant 831 831 GLN HIS 4ZJV_D MODEL Neutral none predicted - - 9.111e-06 rs759310509 ENST00000333602 deleterious(0.01) possibly_damaging(0.766) - Inhibitor_Mig-6 3:195594631 3:195867760 9 2.12
link to download the report for this variant 831 831 GLN LYS 4ZJV_D MODEL Neutral none predicted - - 0.0 rs1225083696 ENST00000333602 tolerated(1) benign(0.296) - Inhibitor_Mig-6 3:195594633 3:195867762 9 5.06
link to download the report for this variant 832 832 VAL MET 4ZJV_D MODEL Neutral none predicted - - - rs900630482 ENST00000333602 deleterious(0) possibly_damaging(0.837) - Inhibitor_Mig-6 3:195594630 3:195867759 0 5.06
link to download the report for this variant 832 832 VAL LEU 4ZJV_D MODEL Neutral none predicted - - - rs900630482 ENST00000333602 deleterious(0) possibly_damaging(0.837) - Inhibitor_Mig-6 3:195594630 3:195867759 0 5.06
link to download the report for this variant 833 833 ILE VAL 4ZJV_D MODEL Neutral none predicted - - 0.0 rs1451476860 ENST00000333602 tolerated(0.08) benign(0.28) - Inhibitor_Mig-6 3:195594627 3:195867756 26 5.06
link to download the report for this variant 835 835 ALA VAL 4ZJV_D MODEL Neutral none predicted - - 4.44e-06 rs1333866000 ENST00000333602 tolerated(0.1) possibly_damaging(0.596) - Inhibitor_Mig-6 3:195594620 3:195867749 0 5.06
link to download the report for this variant 836 836 PRO SER 4ZJV_D MODEL Neutral none predicted - - 4.443e-06 rs774327601 ENST00000333602 tolerated_low_confidence(0.59) benign(0.266) - Inhibitor_Mig-6 3:195594618 3:195867747 0 5.15
link to download the report for this variant 837 837 GLY VAL 4ZJV_D MODEL Neutral none predicted - - 8.85e-06 rs762489031 ENST00000333602 deleterious_low_confidence(0.05) probably_damaging(0.961) - Inhibitor_Mig-6 3:195594614 3:195867743 0 5.15
link to download the report for this variant 837 837 GLY ASP 4ZJV_D MODEL Neutral none predicted - - 8.85e-06 rs762489031 ENST00000333602 deleterious_low_confidence(0.05) probably_damaging(0.961) - Inhibitor_Mig-6 3:195594614 3:195867743 0 5.15
link to download the report for this variant 837 837 GLY SER 4ZJV_D MODEL Neutral none predicted - - 4.416e-06 rs1396165730 ENST00000333602 tolerated_low_confidence(0.07) possibly_damaging(0.802) - Inhibitor_Mig-6 3:195594615 3:195867744 0 5.15
link to download the report for this variant 838 838 PRO LEU 4ZJV_D MODEL Neutral none predicted - - 8.398e-05 rs144573163 ENST00000333602 tolerated_low_confidence(0.09) benign(0.218) - Inhibitor_Mig-6 3:195594611 3:195867740 0 5.15
link to download the report for this variant 839 839 ARG TRP 4ZJV_D MODEL Neutral none predicted - - 4.394e-06 rs781059806 ENST00000333602 deleterious(0.05) probably_damaging(0.94) - Inhibitor_Mig-6 3:195594609 3:195867738 0 3.27
link to download the report for this variant 839 839 ARG GLN 4ZJV_D MODEL Neutral none predicted - - 0.000114 rs113120669 ENST00000333602 tolerated(0.55) benign(0.427) - Inhibitor_Mig-6 3:195594608 3:195867737 0 5.15
link to download the report for this variant 839 839 ARG LEU 4ZJV_D MODEL Neutral none predicted - - 0.000114 rs113120669 ENST00000333602 tolerated(0.55) benign(0.427) - Inhibitor_Mig-6 3:195594608 3:195867737 0 5.15
link to download the report for this variant 841 841 GLY CYS 4ZJV_D MODEL Neutral none predicted - - 0.0 rs1180333924 ENST00000333602 deleterious(0) possibly_damaging(0.876) - - 3:195594603 3:195867732 0 4.28
link to download the report for this variant 842 842 PRO ALA 4ZJV_D MODEL Damaging Secondary structure altered - - 4.318e-06 rs780578357 ENST00000333602 deleterious(0.01) probably_damaging(0.994) - - 3:195594600 3:195867729 9 4.41
link to download the report for this variant 842 842 PRO SER 4ZJV_D MODEL Damaging Secondary structure altered - - 4.318e-06 rs780578357 ENST00000333602 deleterious(0.01) probably_damaging(0.994) - - 3:195594600 3:195867729 9 4.41
link to download the report for this variant 843 843 CYS TYR 4ZJV_D MODEL Damaging Clash - - 0.0 rs1194007173 ENST00000333602 deleterious(0) possibly_damaging(0.726) - - 3:195594596 3:195867725 52 5.28
link to download the report for this variant 844 844 ILE THR 4ZJV_D MODEL Neutral none predicted - - - rs750450303 ENST00000333602 deleterious(0.01) benign(0.255) - - 3:195594593 3:195867722 52 5.28
link to download the report for this variant 846 846 PRO SER 4ZJV_D MODEL Neutral none predicted - - 1.282e-05 rs149295036 ENST00000333602 tolerated(0.09) probably_damaging(0.996) - - 3:195594588 3:195867717 52 5.28
link to download the report for this variant 847 847 ILE VAL 4ZJV_D MODEL Neutral none predicted - - 4.255e-06 rs764353654 ENST00000333602 deleterious(0.05) possibly_damaging(0.891) - - 3:195594585 3:195867714 4 5.28
link to download the report for this variant 847 847 ILE MET 4ZJV_D MODEL Neutral none predicted - - 4.274e-06 rs759346611 ENST00000333602 deleterious(0.05) probably_damaging(0.995) - - 3:195594583 3:195867712 4 -3.45
link to download the report for this variant 848 848 VAL ILE 4ZJV_D MODEL Neutral none predicted - - 2.121e-05 rs751345683 ENST00000333602 tolerated(0.1) benign(0.23) - - 3:195594582 3:195867711 4 3.47
link to download the report for this variant 849 849 ARG GLN 4ZJV_D MODEL Neutral none predicted - - 5.922e-05 rs762813304 ENST00000333602 deleterious(0.04) possibly_damaging(0.846) - - 3:195594578 3:195867707 0 3.47
link to download the report for this variant 849 849 ARG TRP 4ZJV_D MODEL Neutral none predicted - - - rs550521078 ENST00000333602 deleterious(0) possibly_damaging(0.873) - - 3:195594579 3:195867708 4 4.4
link to download the report for this variant 849 849 ARG GLY 4ZJV_D MODEL Neutral none predicted - - - rs550521078 ENST00000333602 deleterious(0) possibly_damaging(0.873) - - 3:195594579 3:195867708 4 4.4
link to download the report for this variant 850 850 ASP GLY 4ZJV_D MODEL Neutral none predicted - - 4.226e-06 rs761465390 ENST00000333602 deleterious(0.04) probably_damaging(0.989) - - 3:195594575 3:195867704 0 5.28
link to download the report for this variant 850 850 ASP ASN 4ZJV_D MODEL Neutral none predicted - - 1.268e-05 rs368791865 ENST00000333602 deleterious(0.04) probably_damaging(0.989) - - 3:195594576 3:195867705 1 4.41
link to download the report for this variant 852 852 LYS ASN 4ZJV_D MODEL Neutral none predicted - - 4.208e-06 rs915031121 ENST00000333602 deleterious(0.02) benign(0.062) - - 3:195594568 3:195867697 47 4.41
link to download the report for this variant 853 853 LYS THR 4ZJV_D MODEL Neutral none predicted - - 4.208e-06 rs139623696 ENST00000333602 deleterious(0.03) probably_damaging(0.991) - - 3:195594566 3:195867695 47 5.28
link to download the report for this variant 853 853 LYS ARG 4ZJV_D MODEL Neutral none predicted - - 4.208e-06 rs139623696 ENST00000333602 deleterious(0.03) probably_damaging(0.991) - - 3:195594566 3:195867695 47 5.28
link to download the report for this variant 853 853 LYS ASN 4ZJV_D MODEL Neutral none predicted - - 4.201e-06 rs776400682 ENST00000333602 deleterious(0) probably_damaging(0.991) - - 3:195594565 3:195867694 47 4.4
link to download the report for this variant 855 855 SER ARG 4ZJV_D MODEL Neutral none predicted - - 4.202e-06 rs768232095 ENST00000333602 deleterious(0) probably_damaging(0.986) - - 3:195594559 3:195867688 19 4.41
link to download the report for this variant 858 858 HIS TYR 4ZJV_D MODEL Neutral none predicted - - 0.0 rs1179377316 ENST00000333602 deleterious(0) probably_damaging(0.968) - - 3:195594552 3:195867681 64 5.28
link to download the report for this variant 859 859 TYR CYS 4ZJV_D MODEL Neutral none predicted - - - rs1224962791 ENST00000333602 deleterious(0.01) probably_damaging(0.996) - - 3:195594548 3:195867677 64 5.28
link to download the report for this variant 860 860 TYR CYS 4ZJV_D MODEL Neutral none predicted - - - rs1265780719 ENST00000333602 deleterious(0) probably_damaging(0.996) - - 3:195594545 3:195867674 64 5.28
link to download the report for this variant 862 862 LEU MET 4ZJV_D MODEL Neutral none predicted - - - rs1349523219 ENST00000333602 deleterious(0) probably_damaging(0.996) - - 3:195594540 3:195867669 43 4.41
link to download the report for this variant 863 863 PRO LEU 4ZJV_D MODEL Neutral none predicted - - 4.233e-06 rs746375967 ENST00000333602 deleterious(0) probably_damaging(0.998) - - 3:195594536 3:195867665 43 5.28
link to download the report for this variant 863 863 PRO HIS 4ZJV_D MODEL Neutral none predicted - - 4.233e-06 rs746375967 ENST00000333602 deleterious(0) probably_damaging(0.998) - - 3:195594536 3:195867665 43 5.28
link to download the report for this variant 863 863 PRO SER 4ZJV_D MODEL Neutral none predicted - - - rs1464655598 ENST00000333602 deleterious(0) probably_damaging(0.996) - - 3:195594537 3:195867666 43 5.28
link to download the report for this variant 864 864 GLU LYS 4ZJV_D MODEL Neutral none predicted - - 1.696e-05 rs143850445 ENST00000333602 deleterious(0.02) probably_damaging(0.981) - - 3:195594534 3:195867663 43 5.28
link to download the report for this variant 864 864 GLU GLN 4ZJV_D MODEL Neutral none predicted - - 1.696e-05 rs143850445 ENST00000333602 deleterious(0.02) probably_damaging(0.981) - - 3:195594534 3:195867663 43 5.28
link to download the report for this variant 864 864 GLU GLY 4ZJV_D MODEL Neutral none predicted - - 0.0001357 rs778020093 ENST00000333602 deleterious(0) probably_damaging(0.986) - - 3:195594533 3:195867662 0 5.28
link to download the report for this variant 132 132 LEU SER 1u46_B PDB Neutral none predicted - - 4.061e-06 rs761446812 ENST00000381916 tolerated(0.19) benign(0.433) - Pkinase_Tyr 3:195613876 3:195887005 34 4.61
link to download the report for this variant 168 168 PRO LEU 1u46_A PDB Neutral none predicted - - - rs1377985065 ENST00000381916 tolerated(0.05) benign(0.318) Yes Pkinase_Tyr 3:195611825 3:195884954 0 4.05
link to download the report for this variant 168 168 PRO SER 1u46_A PDB Neutral none predicted - - 4.074e-06 rs1315439692 ENST00000381916 tolerated(0.18) benign(0.069) Yes Pkinase_Tyr 3:195611826 3:195884955 0 3.07
link to download the report for this variant 233 233 ALA VAL 1u46_B PDB Neutral none predicted - - 4.069e-06 rs1194573822 ENST00000381916 tolerated(0.24) benign(0.103) - Pkinase_Tyr 3:195610128 3:195883257 1 5.44
link to download the report for this variant 260 260 LEU PHE 1u46_B PDB Neutral none predicted - - - rs1459113556 ENST00000381916 deleterious(0.03) probably_damaging(0.987) - Pkinase_Tyr 3:195610048 3:195883177 51 5.44
link to download the report for this variant 273 273 LEU GLN 1u46_B PDB Neutral none predicted - - 2.45e-05 rs372035229 ENST00000381916 deleterious(0.01) probably_damaging(0.956) - Pkinase_Tyr 3:195609180 3:195882309 44 5.41
link to download the report for this variant 277 277 LEU SER 1u46_B PDB Neutral none predicted - - 4.076e-06 rs756635191 ENST00000381916 deleterious(0) probably_damaging(1) - Pkinase_Tyr 3:195609168 3:195882297 0 5.41
link to download the report for this variant 308 308 SER PHE 1u46_B PDB Neutral none predicted - - 1.218e-05 rs751941326 ENST00000381916 deleterious(0) possibly_damaging(0.656) - Pkinase_Tyr 3:195609075 3:195882204 23 4.88
link to download the report for this variant 417 417 GLU LYS 4hzs_D PDB Neutral none predicted - - 4.108e-06 rs770494199 ENST00000381916 tolerated(0.06) possibly_damaging(0.874) - SH3_9 3:195605418 3:195878547 26 4.91
link to download the report for this variant 451 507 ALA VAL 1cf4_B PDB Neutral none predicted - - 4.061e-06 rs749939902 ENST00000381916 tolerated(0.17) benign(0.394) - GTPase_binding 3:195605217 3:195878346 49 4.47
link to download the report for this variant 486 542 TYR CYS 1cf4_B PDB Neutral none predicted - - 4.306e-06 rs1464956309 ENST00000381916 deleterious(0.01) probably_damaging(0.999) - GTPase_binding 3:195599330 3:195872459 1 5.12
link to download the report for this variant 808 808 SER ARG 4ZJV_C MODEL Neutral none predicted - - 4.5e-06 rs781154321 ENST00000381916 tolerated_low_confidence(0.14) benign(0) - Inhibitor_Mig-6 3:195594934 3:195868063 13 4.43
link to download the report for this variant 825 825 PRO THR 4ZJV_D MODEL Neutral none predicted - - 5.234e-06 rs1194346623 ENST00000381916 deleterious_low_confidence(0.03) probably_damaging(0.999) - Inhibitor_Mig-6 3:195594885 3:195868014 13 5.01
link to download the report for this variant 825 825 PRO ALA 4ZJV_D MODEL Neutral none predicted - - 5.234e-06 rs1194346623 ENST00000381916 deleterious_low_confidence(0.03) probably_damaging(0.999) - Inhibitor_Mig-6 3:195594885 3:195868014 13 5.01
link to download the report for this variant 830 830 PRO ALA 4ZJV_D MODEL Neutral none predicted - - 5.881e-06 rs999242860 ENST00000381916 tolerated_low_confidence(0.5) benign(0) - Inhibitor_Mig-6 3:195594870 3:195867999 0 3.16
link to download the report for this variant 832 832 VAL ILE 4ZJV_D MODEL Neutral none predicted - - 3.041e-05 rs772366417 ENST00000381916 tolerated_low_confidence(0.42) benign(0.009) - Inhibitor_Mig-6 3:195594864 3:195867993 0 4.13
link to download the report for this variant 838 838 PRO SER 4ZJV_D MODEL Neutral none predicted - - 6.462e-06 rs1198407541 ENST00000381916 tolerated_low_confidence(0.72) benign(0.003) - Inhibitor_Mig-6 3:195594846 3:195867975 3 -0.81
link to download the report for this variant 862 862 LEU VAL 4ZJV_D MODEL Neutral none predicted - - 2.498e-05 rs766464064 ENST00000381916 deleterious_low_confidence(0.02) benign(0.006) - - 3:195594774 3:195867903 0 2.25
link to download the report for this variant 862 862 LEU PRO 4ZJV_D MODEL Damaging Disallowed phi/psi - - - rs1286557771 ENST00000381916 deleterious_low_confidence(0) possibly_damaging(0.735) - - 3:195594773 3:195867902 0 4.33


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version 1.5.4 22/11/22