Missense3D-DB results

(structural effect of missense variants)

Note: In this version of the database, the structural analysis is based on the impact of a variant on the protein tertiary structure. The missense variant may disrupt additional features (e.g. protein-protein interactions or functional sites) that we are currently not capturing.

UniProt ID: Q13155     Gene name: AIMP2     pLI score: 0.0 tooltip info, click for explanation of pLI score     RVIS score: 0.25 (61.0 %) tooltip info, click for explanation of RVIS scores

tooltip info, click on the Download Report checkbox to display the column which supports the download of a custom report in the results table    tooltip info, click on the UniProt Position checkbox to display the uniprot position column in the results table    tooltip info, click on the PDB/Model Position checkbox to display the PDB or Model position column in the results table    tooltip info, click on the Residue Wildtype checkbox to display the wildtype residue column in the results table    tooltip info, click on the Residue Mutant checkbox to display the mutant residue column in the results table    tooltip info, click on the Structure checkbox to display the PDB/structure id column in the results table    tooltip info, click on the Structure Type checkbox to display the PDB/Phyre model column in the results table    tooltip info, click on the Missense3D Prediction checkbox to display the Missense3D Prediction column in the results table    tooltip info, click on the Structural damage predicted checkbox to display the column detailing whether structural damage is predicted in the results table    tooltip info, click on the Humsavar annotation checkbox to display the Humsavar annotation column in the results table    tooltip info, click on the ClinVar annotation checkbox to display the ClinVar annotation column in the results table    tooltip info, click on the MAF score checkbox to display the MAF score column in the results table    tooltip info, click on the dbSNP checkbox to display the dbSNP id column in the results table    tooltip info, click on the Ensemble ID checkbox to display the Ensemble ID column in the results table    tooltip info, click on the SIFT prediction(score) checkbox to display the SIFT prediction and score column in the results table    tooltip info, click on the PolyPhen-2 prediction(score) checkbox to display the PolyPhen-2 prediction and score column in the results table    tooltip info, click on the Interface(source RCSB) checkbox to display the Interface column in the results table    tooltip info, click on the Pfam domain checkbox to display the Pfam domain id column in the results table    tooltip info, click on the Location (GRCh37) checkbox to display the column containing the GRCh37 Chromosome location in the results table    tooltip info, click on the Location (GRCh38) checkbox to display the column containing the GRCh38 Chromosome location in the results table    tooltip info, click on the CCR percentile checkbox to display the conserved coding region percentile column in the results table    tooltip info, click on the GERP score checkbox to display the GERP score column in the results table

If your variant is not present in the table below click here to use our missense3d website to analyse it using your own 3D structural model.

Download Report Uniprot Position PDB/Model Position Residue Wildtype Residue Mutant Structure Structure Type Missense3D Prediction Structural damage predicted Humsavar Annotation ClinVar Annotation MAF score dbSNP Ensemble ID SIFT prediction(score) PolyPhen-2 prediction(score) Interface(source RCSB) Pfam domain Location (GRCh37) Location (GRCh38) CCR percentile GERP score
link to download the report for this variant 129 129 ALA GLY 5a5h_H PDB Neutral none predicted Benign - - - - tolerated(0.34) benign(0.225) - Thioredoxin_16 - - - -
link to download the report for this variant 166 166 LEU ILE 5a5h_H PDB Neutral none predicted Benign - 0.0069 rs34525431 ENST00000223029 tolerated(0.17) benign(0.042) Yes Thioredoxin_16 7:6057598 7:6017967 0 2.88
link to download the report for this variant 209 209 GLY SER 5a5h_H PDB Damaging Disallowed phi/psi; Gly in a bend Unclassified - - rs982080297 ENST00000223029 deleterious(0) probably_damaging(1) Yes - 7:6062984 7:6023353 20 4.49
link to download the report for this variant 6 6 VAL LEU 6ild_C PDB Neutral none predicted - Not_provided 0.00108 rs139842556 ENST00000223029 tolerated(0.1) benign(0.04) Yes AIMP2_LysRS_bd 7:6049010 7:6009379 - 4.32
link to download the report for this variant 2 2 PRO ARG 6ild_C PDB Neutral none predicted - - - rs1401543115 ENST00000223029 deleterious(0) probably_damaging(0.981) Yes AIMP2_LysRS_bd 7:6048999 7:6009368 - 5.2
link to download the report for this variant 3 3 MET THR 6ild_C PDB Neutral none predicted - - - rs1408389683 ENST00000223029 deleterious(0) possibly_damaging(0.836) Yes AIMP2_LysRS_bd 7:6049002 7:6009371 - 5.2
link to download the report for this variant 4 4 TYR HIS 6ild_C PDB Neutral none predicted - - 4.073e-06 rs767031199 ENST00000223029 deleterious(0) probably_damaging(0.961) Yes AIMP2_LysRS_bd 7:6049004 7:6009373 - 4.03
link to download the report for this variant 5 5 GLN HIS 6ild_C PDB Neutral none predicted - - 8.554e-05 rs754373311 ENST00000223029 deleterious(0.01) possibly_damaging(0.66) Yes AIMP2_LysRS_bd 7:6049009 7:6009378 - 5.2
link to download the report for this variant 8 8 PRO SER 6ild_C PDB Neutral none predicted - - 4.075e-06 rs377537932 ENST00000223029 deleterious(0.02) benign(0.213) Yes AIMP2_LysRS_bd 7:6049016 7:6009385 - 4.32
link to download the report for this variant 8 8 PRO ARG 6ild_C PDB Neutral none predicted - - 4.075e-06 rs1434767478 ENST00000223029 deleterious(0) possibly_damaging(0.895) Yes AIMP2_LysRS_bd 7:6049017 7:6009386 - 5.2
link to download the report for this variant 9 9 TYR HIS 6ild_C PDB Neutral none predicted - - 4.077e-06 rs371044703 ENST00000223029 deleterious(0.01) possibly_damaging(0.742) Yes AIMP2_LysRS_bd 7:6049019 7:6009388 - 5.2
link to download the report for this variant 10 10 HIS GLN 6ild_C PDB Neutral none predicted - - - rs777401869 ENST00000223029 tolerated(0.1) benign(0.007) Yes AIMP2_LysRS_bd 7:6049024 7:6009393 - 2.38
link to download the report for this variant 11 11 GLY ALA 6ild_C PDB Damaging Disallowed phi/psi - - - rs1049013110 ENST00000223029 tolerated(0.18) benign(0.007) Yes AIMP2_LysRS_bd 7:6049026 7:6009395 - 0.95
link to download the report for this variant 12 12 GLY SER 6ild_C PDB Damaging Gly in a bend - - 4.078e-06 rs1367182950 ENST00000223029 tolerated(0.59) benign(0.031) Yes AIMP2_LysRS_bd 7:6049028 7:6009397 - 3.4
link to download the report for this variant 13 13 GLY ASP 6ild_C PDB Damaging Gly in a bend - - 0.0 rs1305890535 ENST00000223029 tolerated(0.86) benign(0) Yes AIMP2_LysRS_bd 7:6049032 7:6009401 - 4.32
link to download the report for this variant 15 15 PRO ALA 6ild_C PDB Neutral none predicted - - 0.0001183 rs145891242 ENST00000223029 tolerated(0.57) benign(0.006) Yes AIMP2_LysRS_bd 7:6049037 7:6009406 - 0.41
link to download the report for this variant 15 15 PRO LEU 6ild_C PDB Neutral none predicted - - 4.079e-06 rs745755330 ENST00000223029 tolerated(0.41) benign(0.001) Yes AIMP2_LysRS_bd 7:6049038 7:6009407 - 3.17
link to download the report for this variant 16 16 LEU ILE 6ild_C PDB Neutral none predicted - - 8.159e-06 rs768787708 ENST00000223029 deleterious(0.03) possibly_damaging(0.483) Yes AIMP2_LysRS_bd 7:6049040 7:6009409 - 4.32
link to download the report for this variant 16 16 LEU PHE 6ild_C PDB Neutral none predicted - - 8.159e-06 rs768787708 ENST00000223029 deleterious(0.03) possibly_damaging(0.483) Yes AIMP2_LysRS_bd 7:6049040 7:6009409 - 4.32
link to download the report for this variant 17 17 ARG CYS 6ild_C PDB Neutral none predicted - - 4.081e-06 rs1205665747 ENST00000223029 tolerated(0.1) benign(0) Yes AIMP2_LysRS_bd 7:6049043 7:6009412 - 3.26
link to download the report for this variant 17 17 ARG HIS 6ild_C PDB Neutral none predicted - - 8.163e-06 rs774238548 ENST00000223029 tolerated(0.28) benign(0) Yes AIMP2_LysRS_bd 7:6049044 7:6009413 - -2.94
link to download the report for this variant 18 18 VAL GLU 6ild_C PDB Neutral none predicted - - 4.082e-06 rs1254470488 ENST00000223029 tolerated(0.07) benign(0.023) Yes AIMP2_LysRS_bd 7:6049047 7:6009416 - 4.03
link to download the report for this variant 18 18 VAL MET 6ild_C PDB Neutral none predicted - - 4.082e-06 rs772489394 ENST00000223029 deleterious(0.01) possibly_damaging(0.748) Yes AIMP2_LysRS_bd 7:6049046 7:6009415 - 5.2
link to download the report for this variant 20 20 LEU PHE 6ild_C PDB Neutral none predicted - - 4.087e-06 rs761170066 ENST00000223029 deleterious(0.01) probably_damaging(0.999) Yes AIMP2_LysRS_bd 7:6049052 7:6009421 - 4.21
link to download the report for this variant 21 21 PRO LEU 6ild_C PDB Neutral none predicted - - 1.226e-05 rs777224660 ENST00000223029 deleterious(0) probably_damaging(1) Yes AIMP2_LysRS_bd 7:6049056 7:6009425 - 5.09
link to download the report for this variant 21 21 PRO ALA 6ild_C PDB Neutral none predicted - - 4.087e-06 rs766798963 ENST00000223029 deleterious(0) probably_damaging(0.999) Yes AIMP2_LysRS_bd 7:6049055 7:6009424 - 5.09
link to download the report for this variant 22 22 THR SER 6ild_C PDB Neutral none predicted - - 4.094e-06 rs563884789 ENST00000223029 deleterious(0) possibly_damaging(0.837) Yes AIMP2_LysRS_bd 7:6049059 7:6009428 - 5.09
link to download the report for this variant 22 22 THR ILE 6ild_C PDB Neutral none predicted - - 4.094e-06 rs563884789 ENST00000223029 deleterious(0) possibly_damaging(0.837) Yes AIMP2_LysRS_bd 7:6049059 7:6009428 - 5.09
link to download the report for this variant 22 22 THR ALA 6ild_C PDB Neutral none predicted - - 4.096e-06 rs764813325 ENST00000223029 deleterious(0.04) benign(0.356) Yes AIMP2_LysRS_bd 7:6049058 7:6009427 - 3.93
link to download the report for this variant 23 23 CYS GLY 6ild_C PDB Neutral none predicted - - 4.094e-06 rs1371935734 ENST00000223029 deleterious(0) possibly_damaging(0.755) Yes AIMP2_LysRS_bd 7:6049061 7:6009430 - 5.13
link to download the report for this variant 23 23 CYS SER 6ild_C PDB Neutral none predicted - - 4.094e-06 rs1371935734 ENST00000223029 deleterious(0) possibly_damaging(0.755) Yes AIMP2_LysRS_bd 7:6049061 7:6009430 - 5.13
link to download the report for this variant 24 24 MET VAL 6ild_C PDB Neutral none predicted - - - rs1178019019 ENST00000223029 deleterious(0) possibly_damaging(0.689) Yes AIMP2_LysRS_bd 7:6049064 7:6009433 - 5.13
link to download the report for this variant 24 24 MET ARG 6ild_C PDB Neutral none predicted - - - rs1324538398 ENST00000223029 deleterious(0) benign(0.058) Yes AIMP2_LysRS_bd 7:6049065 7:6009434 - 5.13
link to download the report for this variant 24 24 MET THR 6ild_C PDB Neutral none predicted - - - rs1324538398 ENST00000223029 deleterious(0) benign(0.058) Yes AIMP2_LysRS_bd 7:6049065 7:6009434 - 5.13
link to download the report for this variant 24 24 MET ILE 6ild_C PDB Neutral none predicted - - 1.231e-05 rs763789143 ENST00000223029 deleterious(0.02) possibly_damaging(0.756) Yes AIMP2_LysRS_bd 7:6049066 7:6009435 - 4.24
link to download the report for this variant 25 25 TYR HIS 6ild_C PDB Neutral none predicted - - - rs1163035440 ENST00000223029 deleterious(0) probably_damaging(0.991) Yes AIMP2_LysRS_bd 7:6049067 7:6009436 - 5.13
link to download the report for this variant 25 25 TYR SER 6ild_C PDB Neutral none predicted - - 1.231e-05 rs147658637 ENST00000223029 deleterious(0) probably_damaging(0.988) Yes AIMP2_LysRS_bd 7:6049068 7:6009437 - 5.13
link to download the report for this variant 26 26 ARG GLY 6ild_C PDB Neutral none predicted - - - rs757077360 ENST00000223029 deleterious(0) benign(0.203) Yes AIMP2_LysRS_bd 7:6049070 7:6009439 - 4.25
link to download the report for this variant 27 27 LEU PHE 6ild_C PDB Neutral none predicted - - - rs1410082930 ENST00000223029 deleterious(0.01) benign(0.023) Yes AIMP2_LysRS_bd 7:6049073 7:6009442 - 4.21
link to download the report for this variant 29 29 ASN SER 6ild_C PDB Neutral none predicted - - 4.122e-06 rs1289756357 ENST00000223029 deleterious(0.03) probably_damaging(0.912) Yes AIMP2_LysRS_bd 7:6049080 7:6009449 - 2.7
link to download the report for this variant 29 29 ASN ILE 6ild_C PDB Neutral none predicted - - 4.122e-06 rs1289756357 ENST00000223029 deleterious(0.03) probably_damaging(0.912) Yes AIMP2_LysRS_bd 7:6049080 7:6009449 - 2.7
link to download the report for this variant 29 29 ASN HIS 6ild_C PDB Neutral none predicted - - - rs1381117753 ENST00000223029 deleterious(0.05) possibly_damaging(0.621) Yes AIMP2_LysRS_bd 7:6049079 7:6009448 - 5.13
link to download the report for this variant 29 29 ASN ASP 6ild_C PDB Neutral none predicted - - - rs1381117753 ENST00000223029 deleterious(0.05) possibly_damaging(0.621) Yes AIMP2_LysRS_bd 7:6049079 7:6009448 - 5.13
link to download the report for this variant 29 29 ASN LYS 6ild_C PDB Neutral none predicted - - 8.253e-06 rs780037791 ENST00000223029 deleterious(0.02) possibly_damaging(0.683) Yes AIMP2_LysRS_bd 7:6049081 7:6009450 - 1.23
link to download the report for this variant 30 30 VAL ALA 6ild_C PDB Neutral none predicted - - - rs1489732343 ENST00000223029 tolerated(0.05) benign(0.009) Yes AIMP2_LysRS_bd 7:6049083 7:6009452 - 5.13
link to download the report for this variant 30 30 VAL LEU 6ild_C PDB Neutral none predicted - - 4.128e-06 rs748215903 ENST00000223029 tolerated(0.25) benign(0.028) Yes AIMP2_LysRS_bd 7:6049082 7:6009451 - 2.02
link to download the report for this variant 31 31 HIS GLN 6ild_C PDB Neutral none predicted - - 4.56e-05 rs200865484 ENST00000223029 tolerated(0.08) benign(0.096) Yes AIMP2_LysRS_bd 7:6049087 7:6009456 - 3.34
link to download the report for this variant 31 31 HIS ASN 6ild_C PDB Neutral none predicted - - 1.24e-05 rs772254141 ENST00000223029 tolerated(0.15) possibly_damaging(0.466) Yes AIMP2_LysRS_bd 7:6049085 7:6009454 - 5.13
link to download the report for this variant 31 31 HIS TYR 6ild_C PDB Neutral none predicted - - 1.24e-05 rs772254141 ENST00000223029 tolerated(0.15) possibly_damaging(0.466) Yes AIMP2_LysRS_bd 7:6049085 7:6009454 - 5.13
link to download the report for this variant 32 32 GLY SER 4ycu_C PDB Neutral none predicted - - 8.291e-06 rs200362634 ENST00000223029 deleterious(0.03) benign(0.005) Yes AIMP2_LysRS_bd 7:6049088 7:6009457 - -1.13
link to download the report for this variant 32 32 GLY CYS 4ycu_C PDB Neutral none predicted - - 8.291e-06 rs200362634 ENST00000223029 deleterious(0.03) benign(0.005) Yes AIMP2_LysRS_bd 7:6049088 7:6009457 - -1.13
link to download the report for this variant 105 105 ALA GLU 5a5h_D PDB Neutral none predicted - - 1.218e-05 rs774134623 ENST00000223029 tolerated(0.19) benign(0.006) - - 7:6054955 7:6015324 15 0.02
link to download the report for this variant 105 105 ALA VAL 5a5h_D PDB Neutral none predicted - - 1.218e-05 rs774134623 ENST00000223029 tolerated(0.19) benign(0.006) - - 7:6054955 7:6015324 15 0.02
link to download the report for this variant 107 107 ASP TYR 5a5h_D PDB Neutral none predicted - - 2.436e-05 rs754061405 ENST00000223029 deleterious(0.01) probably_damaging(0.955) Yes - 7:6054960 7:6015329 53 4.24
link to download the report for this variant 108 108 LEU PHE 5a5h_D PDB Neutral none predicted - - - rs1447045312 ENST00000223029 deleterious(0) probably_damaging(0.965) - - 7:6054965 7:6015334 53 0.49
link to download the report for this variant 109 109 ASN LYS 5a5h_D PDB Neutral none predicted - - - rs1211111262 ENST00000223029 deleterious(0.01) benign(0.152) - - 7:6054968 7:6015337 53 -1.82
link to download the report for this variant 109 109 ASN SER 5a5h_D PDB Neutral none predicted - - - rs990903521 ENST00000223029 tolerated(0.14) benign(0.03) - - 7:6054967 7:6015336 53 5.13
link to download the report for this variant 111 111 VAL MET 5a5h_D PDB Neutral none predicted - - 5.279e-05 rs375295993 ENST00000223029 tolerated(0.41) benign(0.03) Yes - 7:6054972 7:6015341 21 1.92
link to download the report for this variant 113 113 GLY ARG 5a5h_D PDB Damaging Disallowed phi/psi - - 4.061e-06 rs373626338 ENST00000223029 deleterious(0) probably_damaging(0.996) Yes - 7:6054978 7:6015347 5 5.13
link to download the report for this variant 114 114 LYS GLN 5a5h_D PDB Neutral none predicted - - 4.061e-06 rs758656381 ENST00000223029 tolerated(0.19) benign(0.051) Yes - 7:6054981 7:6015350 5 3.96
link to download the report for this variant 115 115 ASP ASN 5a5h_D PDB Neutral none predicted - - 4.094e-06 rs768501526 ENST00000223029 deleterious(0.05) probably_damaging(0.959) Yes - 7:6057445 7:6017814 5 5.05
link to download the report for this variant 115 115 ASP HIS 5a5h_D PDB Neutral none predicted - - 4.094e-06 rs768501526 ENST00000223029 deleterious(0.05) probably_damaging(0.959) Yes - 7:6057445 7:6017814 5 5.05
link to download the report for this variant 116 116 TYR SER 5a5h_D PDB Neutral none predicted - - 4.089e-06 rs1294023165 ENST00000223029 tolerated(0.36) possibly_damaging(0.495) Yes - 7:6057449 7:6017818 1 5.93
link to download the report for this variant 116 116 TYR HIS 5a5h_D PDB Neutral none predicted - - 1.226e-05 rs778512251 ENST00000223029 tolerated(0.46) benign(0.022) Yes - 7:6057448 7:6017817 0 3.51
link to download the report for this variant 117 117 GLY ARG 5a5h_F PDB Neutral none predicted - - 2.863e-05 rs375102151 ENST00000223029 deleterious(0.05) probably_damaging(0.99) Yes - 7:6057451 7:6017820 10 5.93
link to download the report for this variant 118 118 ALA VAL 5a5h_F PDB Neutral none predicted - - 4.084e-06 rs773098686 ENST00000223029 tolerated(0.21) probably_damaging(0.983) Yes Thioredoxin_16 7:6057455 7:6017824 1 5.05
link to download the report for this variant 119 119 LEU VAL 5a5h_F PDB Neutral none predicted - - 1.223e-05 rs769710704 ENST00000223029 tolerated(0.11) possibly_damaging(0.771) Yes Thioredoxin_16 7:6057457 7:6017826 5 3.91
link to download the report for this variant 120 120 LYS GLN 5a5h_H PDB Neutral none predicted - - 7.334e-05 rs775788927 ENST00000223029 tolerated(0.22) benign(0.203) - Thioredoxin_16 7:6057460 7:6017829 10 4.75
link to download the report for this variant 121 121 ASP GLY 5a5h_H PDB Damaging Disallowed phi/psi - - 4.073e-06 rs200028351 ENST00000223029 deleterious(0) probably_damaging(1) Yes Thioredoxin_16 7:6057464 7:6017833 1 5.93
link to download the report for this variant 122 122 ILE LEU 5a5h_H PDB Neutral none predicted - - 8.142e-06 rs763030358 ENST00000223029 tolerated(0.23) benign(0.087) - Thioredoxin_16 7:6057466 7:6017835 0 5.93
link to download the report for this variant 122 122 ILE VAL 5a5h_H PDB Neutral none predicted - - 8.142e-06 rs763030358 ENST00000223029 tolerated(0.23) benign(0.087) - Thioredoxin_16 7:6057466 7:6017835 0 5.93
link to download the report for this variant 122 122 ILE SER 5a5h_H PDB Neutral none predicted - - - rs764368950 ENST00000223029 deleterious(0) probably_damaging(0.945) - Thioredoxin_16 7:6057467 7:6017836 9 5.93
link to download the report for this variant 122 122 ILE THR 5a5h_H PDB Neutral none predicted - - - rs764368950 ENST00000223029 deleterious(0) probably_damaging(0.945) - Thioredoxin_16 7:6057467 7:6017836 9 5.93
link to download the report for this variant 123 123 VAL MET 5a5h_H PDB Neutral none predicted - - - - - deleterious(0) probably_damaging(0.999) Yes Thioredoxin_16 - - - -
link to download the report for this variant 124 124 ILE LEU 5a5h_H PDB Neutral none predicted - - - rs1304859703 ENST00000223029 deleterious(0.04) possibly_damaging(0.799) - Thioredoxin_16 7:6057472 7:6017841 9 5.93
link to download the report for this variant 124 124 ILE MET 5a5h_H PDB Neutral none predicted - - 4.069e-06 rs762237456 ENST00000223029 deleterious(0) probably_damaging(0.987) - Thioredoxin_16 7:6057474 7:6017843 1 5.93
link to download the report for this variant 125 125 ASN SER 5a5h_H PDB Neutral none predicted - - 4.068e-06 rs750912720 ENST00000223029 tolerated(0.15) probably_damaging(0.979) - Thioredoxin_16 7:6057476 7:6017845 1 5.93
link to download the report for this variant 126 126 ALA THR 5a5h_H PDB Neutral none predicted - - 0.0001099 rs550952758 ENST00000223029 tolerated(0.07) possibly_damaging(0.854) - Thioredoxin_16 7:6057478 7:6017847 21 5.93
link to download the report for this variant 127 127 ASN HIS 5a5h_H PDB Neutral none predicted - - 4.067e-06 rs373372974 ENST00000223029 deleterious(0) probably_damaging(0.994) - Thioredoxin_16 7:6057481 7:6017850 21 5.93
link to download the report for this variant 128 128 PRO LEU 5a5h_H PDB Neutral none predicted - - 8.135e-06 rs747974072 ENST00000223029 deleterious(0) probably_damaging(1) - Thioredoxin_16 7:6057485 7:6017854 0 5.93
link to download the report for this variant 128 128 PRO ALA 5a5h_H PDB Neutral none predicted - - 4.067e-06 rs778622819 ENST00000223029 deleterious(0.01) probably_damaging(1) - Thioredoxin_16 7:6057484 7:6017853 0 5.93
link to download the report for this variant 128 128 PRO SER 5a5h_H PDB Neutral none predicted - - 4.067e-06 rs778622819 ENST00000223029 deleterious(0.01) probably_damaging(1) - Thioredoxin_16 7:6057484 7:6017853 0 5.93
link to download the report for this variant 129 129 ALA VAL 5a5h_H PDB Neutral none predicted - - 4.066e-06 rs17855441 ENST00000223029 tolerated(0.08) benign(0.037) - Thioredoxin_16 7:6057488 7:6017857 5 5.93
link to download the report for this variant 130 130 SER PHE 5a5h_H PDB Neutral none predicted - - 4.065e-06 rs777707483 ENST00000223029 tolerated(0.61) benign(0.154) - Thioredoxin_16 7:6057491 7:6017860 33 3.71
link to download the report for this variant 131 131 PRO ALA 5a5h_H PDB Neutral none predicted - - - rs1296381315 ENST00000223029 deleterious(0.04) benign(0.345) - Thioredoxin_16 7:6057493 7:6017862 33 5.82
link to download the report for this variant 131 131 PRO LEU 5a5h_H PDB Neutral none predicted - - - - - deleterious(0) probably_damaging(0.938) - Thioredoxin_16 - - - -
link to download the report for this variant 133 133 LEU PHE 5a5h_H PDB Damaging Buried H-bond breakage - - 4.064e-06 rs1231114699 ENST00000223029 tolerated(0.06) possibly_damaging(0.784) - Thioredoxin_16 7:6057499 7:6017868 0 5.82
link to download the report for this variant 133 133 LEU PRO 5a5h_H PDB Damaging Buried Pro introduced; Buried H-bond breakage; Buried / exposed switch - - 8.128e-06 rs746905456 ENST00000223029 deleterious(0) probably_damaging(0.951) - Thioredoxin_16 7:6057500 7:6017869 5 5.82
link to download the report for this variant 134 134 SER PHE 5a5h_H PDB Damaging Buried H-bond breakage - - 0.0001178 rs769933568 ENST00000223029 deleterious(0) probably_damaging(0.991) - Thioredoxin_16 7:6057503 7:6017872 49 4.93
link to download the report for this variant 136 136 LEU VAL 5a5h_H PDB Damaging Cavity altered - - - rs1431221728 ENST00000223029 deleterious(0.02) benign(0.247) - Thioredoxin_16 7:6057508 7:6017877 49 3.77
link to download the report for this variant 137 137 VAL LEU 5a5h_H PDB Neutral none predicted - - - - - deleterious(0.04) possibly_damaging(0.496) - Thioredoxin_16 - - - -
link to download the report for this variant 138 138 LEU PRO 5a5h_H PDB Damaging Buried Pro introduced - - 4.063e-06 rs765096358 ENST00000223029 deleterious(0) probably_damaging(0.988) - Thioredoxin_16 7:6057515 7:6017884 65 5.82
link to download the report for this variant 139 139 HIS GLN 5a5h_H PDB Damaging Buried charge replaced - - - rs1424120170 ENST00000223029 deleterious(0.01) probably_damaging(0.981) - Thioredoxin_16 7:6057519 7:6017888 65 3.01
link to download the report for this variant 140 140 ARG SER 5a5h_H PDB Neutral none predicted - - - rs774693908 ENST00000223029 tolerated(0.93) benign(0.001) - Thioredoxin_16 7:6057522 7:6017891 65 2.84
link to download the report for this variant 140 140 ARG LYS 5a5h_H PDB Neutral none predicted - - - rs946176280 ENST00000223029 tolerated(0.82) benign(0.021) - Thioredoxin_16 7:6057521 7:6017890 65 0.46
link to download the report for this variant 141 141 LEU ARG 5a5h_H PDB Neutral none predicted - - - rs1049065707 ENST00000223029 deleterious(0) probably_damaging(0.926) - Thioredoxin_16 7:6057524 7:6017893 65 5.82
link to download the report for this variant 142 142 LEU VAL 5a5h_H PDB Neutral none predicted - - - rs1383497501 ENST00000223029 deleterious(0) probably_damaging(0.998) - Thioredoxin_16 7:6057526 7:6017895 65 5.82
link to download the report for this variant 143 143 CYS SER 5a5h_H PDB Neutral none predicted - - 2.438e-05 rs767955463 ENST00000223029 tolerated(0.35) probably_damaging(0.934) - Thioredoxin_16 7:6057530 7:6017899 0 5.82
link to download the report for this variant 143 143 CYS TYR 5a5h_H PDB Neutral none predicted - - 2.438e-05 rs767955463 ENST00000223029 tolerated(0.35) probably_damaging(0.934) - Thioredoxin_16 7:6057530 7:6017899 0 5.82
link to download the report for this variant 143 143 CYS TRP 5a5h_H PDB Neutral none predicted - - 1.219e-05 rs554964581 ENST00000223029 deleterious(0.02) probably_damaging(0.993) - Thioredoxin_16 7:6057531 7:6017900 15 0.83
link to download the report for this variant 145 145 HIS ARG 5a5h_H PDB Neutral none predicted - - 4.062e-06 rs1167436165 ENST00000223029 tolerated(1) benign(0) - Thioredoxin_16 7:6057536 7:6017905 28 2.1
link to download the report for this variant 147 147 ARG SER 5a5h_H PDB Neutral none predicted - - 8.125e-06 rs761028688 ENST00000223029 tolerated(0.05) benign(0.202) - Thioredoxin_16 7:6057543 7:6017912 0 4.94
link to download the report for this variant 148 148 VAL PHE 5a5h_H PDB Neutral none predicted - - - rs549852720 ENST00000223029 deleterious(0) possibly_damaging(0.85) - Thioredoxin_16 7:6057544 7:6017913 44 4.83
link to download the report for this variant 148 148 VAL ILE 5a5h_H PDB Neutral none predicted - - - rs549852720 ENST00000223029 deleterious(0) possibly_damaging(0.85) - Thioredoxin_16 7:6057544 7:6017913 44 4.83
link to download the report for this variant 151 151 THR MET 5a5h_H PDB Neutral none predicted - - 1.625e-05 rs765640941 ENST00000223029 deleterious(0.01) possibly_damaging(0.795) Yes Thioredoxin_16 7:6057554 7:6017923 15 5.82
link to download the report for this variant 153 153 HIS TYR 5a5h_H PDB Neutral none predicted - - 8.124e-06 rs764843355 ENST00000223029 tolerated(0.05) probably_damaging(0.999) Yes Thioredoxin_16 7:6057559 7:6017928 10 5.82
link to download the report for this variant 154 154 THR MET 5a5h_H PDB Neutral none predicted - - 0.0001787 rs75895975 ENST00000223029 tolerated(0.14) benign(0.237) Yes Thioredoxin_16 7:6057563 7:6017932 5 2.65
link to download the report for this variant 155 155 HIS PRO 5a5h_H PDB Neutral none predicted - - 4.062e-06 rs374990034 ENST00000223029 deleterious(0) probably_damaging(0.999) Yes Thioredoxin_16 7:6057566 7:6017935 5 5.82
link to download the report for this variant 156 156 SER PHE 5a5h_H PDB Neutral none predicted - - 4.062e-06 rs746796665 ENST00000223029 tolerated(0.05) probably_damaging(0.999) Yes Thioredoxin_16 7:6057569 7:6017938 32 5.82
link to download the report for this variant 158 158 VAL LEU 5a5h_F PDB Damaging Clash - - - rs1314840632 ENST00000223029 deleterious(0.01) benign(0.033) - Thioredoxin_16 7:6057574 7:6017943 32 4.02
link to download the report for this variant 159 159 LYS ASN 5a5h_F PDB Neutral none predicted - - 8.124e-06 rs931014900 ENST00000223029 tolerated(0.33) benign(0.101) - Thioredoxin_16 7:6057579 7:6017948 10 0.8
link to download the report for this variant 161 161 VAL GLU 5a5h_H PDB Neutral none predicted - - 4.062e-06 rs774747119 ENST00000223029 deleterious(0.05) probably_damaging(0.984) - Thioredoxin_16 7:6057584 7:6017953 15 5.82
link to download the report for this variant 161 161 VAL MET 5a5h_H PDB Neutral none predicted - - 1.625e-05 rs768732685 ENST00000223029 deleterious(0) probably_damaging(0.977) - Thioredoxin_16 7:6057583 7:6017952 0 5.82
link to download the report for this variant 163 163 GLU LYS 5a5h_H PDB Neutral none predicted - - 1.219e-05 rs1189753900 ENST00000223029 tolerated(0.51) benign(0.318) - Thioredoxin_16 7:6057589 7:6017958 21 3.95
link to download the report for this variant 165 165 LEU PHE 5a5h_H PDB Neutral none predicted - - 8.123e-06 rs1013331223 ENST00000223029 deleterious(0) probably_damaging(0.999) - Thioredoxin_16 7:6057595 7:6017964 5 5.82
link to download the report for this variant 165 165 LEU VAL 5a5h_H PDB Neutral none predicted - - 8.123e-06 rs1013331223 ENST00000223029 deleterious(0) probably_damaging(0.999) - Thioredoxin_16 7:6057595 7:6017964 5 5.82
link to download the report for this variant 166 166 LEU HIS 5a5h_H PDB Neutral none predicted - - 4.062e-06 rs773768066 ENST00000223029 tolerated(0.06) possibly_damaging(0.837) Yes Thioredoxin_16 7:6057599 7:6017968 5 5.82
link to download the report for this variant 167 167 LYS ARG 5a5h_H PDB Neutral none predicted - - 8.123e-06 rs771380350 ENST00000223029 tolerated(0.43) benign(0.006) - Thioredoxin_16 7:6057602 7:6017971 38 -0.59
link to download the report for this variant 168 168 CYS TRP 5a5h_H PDB Neutral none predicted - - 1.219e-05 rs777169814 ENST00000223029 deleterious(0) probably_damaging(0.992) - Thioredoxin_16 7:6057606 7:6017975 38 3.8
link to download the report for this variant 170 170 GLY VAL 5a5h_F PDB Neutral none predicted - - 1.625e-05 rs141537839 ENST00000223029 deleterious(0) probably_damaging(0.999) - Thioredoxin_16 7:6057611 7:6017980 33 5.82
link to download the report for this variant 173 173 ASN SER 5a5h_D PDB Neutral none predicted - - 4.062e-06 rs1335537270 ENST00000223029 tolerated(0.97) benign(0) - Thioredoxin_16 7:6057620 7:6017989 1 3.89
link to download the report for this variant 173 173 ASN LYS 5a5h_D PDB Neutral none predicted - - 0.0001074 rs923027283 ENST00000223029 tolerated(0.87) benign(0.013) - Thioredoxin_16 7:6057621 7:6017990 0 -4.98
link to download the report for this variant 174 174 LYS GLU 5a5h_D PDB Neutral none predicted - - 1.219e-05 rs1441116607 ENST00000223029 tolerated(0.87) benign(0.054) - Thioredoxin_16 7:6057622 7:6017991 5 2.04
link to download the report for this variant 175 175 LYS GLU 5a5h_D PDB Neutral none predicted - - 8.125e-06 rs542587504 ENST00000223029 tolerated(0.88) benign(0.033) - Thioredoxin_16 7:6057625 7:6017994 5 2.04
link to download the report for this variant 175 175 LYS GLN 5a5h_D PDB Neutral none predicted - - 8.125e-06 rs542587504 ENST00000223029 tolerated(0.88) benign(0.033) - Thioredoxin_16 7:6057625 7:6017994 5 2.04
link to download the report for this variant 175 175 LYS ASN 5a5h_D PDB Neutral none predicted - - 4.078e-06 rs762654416 ENST00000223029 tolerated(0.5) benign(0.003) - Thioredoxin_16 7:6057627 7:6017996 0 -9.86
link to download the report for this variant 176 176 GLN HIS 5a5h_D PDB Neutral none predicted - - 7.349e-05 rs751354172 ENST00000223029 tolerated(0.09) benign(0.283) - Thioredoxin_16 7:6057630 7:6017999 21 3.99
link to download the report for this variant 176 176 GLN LYS 5a5h_D PDB Neutral none predicted - - 1.222e-05 rs560844337 ENST00000223029 tolerated(0.5) benign(0.005) - Thioredoxin_16 7:6057628 7:6017997 21 3.86
link to download the report for this variant 177 177 PRO SER 5a5h_D PDB Neutral none predicted - - - rs1205639853 ENST00000223029 tolerated(1) benign(0.001) Yes Thioredoxin_16 7:6057631 7:6018000 21 -1.67
link to download the report for this variant 178 178 ARG HIS 5a5h_F PDB Neutral none predicted - - 0.0 rs766723249 ENST00000223029 deleterious(0) probably_damaging(0.999) Yes Thioredoxin_16 7:6057635 7:6018004 0 5.82
link to download the report for this variant 178 178 ARG GLY 5a5h_F PDB Neutral none predicted - - 4.063e-06 rs200566166 ENST00000223029 deleterious(0) probably_damaging(1) Yes Thioredoxin_16 7:6057634 7:6018003 1 5.82
link to download the report for this variant 178 178 ARG CYS 5a5h_F PDB Neutral none predicted - - 4.063e-06 rs200566166 ENST00000223029 deleterious(0) probably_damaging(1) Yes Thioredoxin_16 7:6057634 7:6018003 1 5.82
link to download the report for this variant 179 179 GLN GLU 5a5h_H PDB Neutral none predicted - - 4.063e-06 rs750336358 ENST00000223029 tolerated(0.14) benign(0.021) Yes Thioredoxin_16 7:6057637 7:6018006 21 5.82
link to download the report for this variant 179 179 GLN ARG 5a5h_H PDB Neutral none predicted - - - - - tolerated(0.42) benign(0.034) Yes Thioredoxin_16 - - - -
link to download the report for this variant 181 181 TYR HIS 5a5h_H PDB Neutral none predicted - - 4.064e-06 rs1234766123 ENST00000223029 tolerated(0.32) benign(0.015) - Thioredoxin_16 7:6057643 7:6018012 10 4.66
link to download the report for this variant 181 181 TYR PHE 5a5h_H PDB Neutral none predicted - - - - - tolerated(0.43) benign(0.006) - Thioredoxin_16 - - - -
link to download the report for this variant 182 182 GLN PRO 5a5h_H PDB Damaging Disallowed phi/psi - - 0.0001341 rs755018110 ENST00000223029 deleterious(0) probably_damaging(0.998) - Thioredoxin_16 7:6057647 7:6018016 0 5.82
link to download the report for this variant 182 182 GLN LEU 5a5h_H PDB Neutral none predicted - - 0.0001341 rs755018110 ENST00000223029 deleterious(0) probably_damaging(0.998) - Thioredoxin_16 7:6057647 7:6018016 0 5.82
link to download the report for this variant 182 182 GLN HIS 5a5h_H PDB Neutral none predicted - - 4.065e-06 rs1393819667 ENST00000223029 deleterious(0) probably_damaging(0.999) - Thioredoxin_16 7:6057648 7:6018017 58 4.01
link to download the report for this variant 184 184 GLY GLU 5a5h_H PDB Damaging Buried Gly replaced; Buried / exposed switch - - - rs779079471 ENST00000223029 deleterious(0) probably_damaging(0.993) - Thioredoxin_16 7:6057653 7:6018022 58 4.91
link to download the report for this variant 187 187 LEU ILE 5a5h_H PDB Neutral none predicted - - 4.076e-06 rs1456013597 ENST00000223029 tolerated(0.06) probably_damaging(0.998) - Thioredoxin_16 7:6057661 7:6018030 10 -0.36
link to download the report for this variant 188 188 ILE ASN 5a5h_H PDB Neutral none predicted - - 4.085e-06 rs1173669660 ENST00000223029 deleterious(0) probably_damaging(0.999) Yes Thioredoxin_16 7:6057665 7:6018034 21 5.67
link to download the report for this variant 190 190 LYS THR 5a5h_H PDB Neutral none predicted - - 4.102e-06 rs1396282189 ENST00000223029 deleterious(0) probably_damaging(0.999) Yes Thioredoxin_16 7:6057671 7:6018040 4 5.67
link to download the report for this variant 190 190 LYS ASN 5a5h_H PDB Neutral none predicted - - - - - deleterious(0) probably_damaging(0.999) Yes Thioredoxin_16 - - - -
link to download the report for this variant 191 191 ASN SER 5a5h_H PDB Neutral none predicted - - 4.111e-06 rs748222802 ENST00000223029 tolerated(0.14) benign(0.23) - Thioredoxin_16 7:6057674 7:6018043 19 5.67
link to download the report for this variant 193 193 PRO ARG 5a5h_H PDB Neutral none predicted - - 5.242e-05 rs776366708 ENST00000223029 tolerated(0.08) possibly_damaging(0.756) Yes Thioredoxin_16 7:6062937 7:6023306 19 4.5
link to download the report for this variant 193 193 PRO LEU 5a5h_H PDB Neutral none predicted - - 5.242e-05 rs776366708 ENST00000223029 tolerated(0.08) possibly_damaging(0.756) Yes Thioredoxin_16 7:6062937 7:6023306 19 4.5
link to download the report for this variant 195 195 THR MET 5a5h_H PDB Neutral none predicted - - 1.288e-05 rs1163788754 ENST00000223029 tolerated(0.18) benign(0.383) - Thioredoxin_16 7:6062943 7:6023312 1 5.37
link to download the report for this variant 195 195 THR ARG 5a5h_H PDB Damaging Clash - - - - - tolerated(0.1) possibly_damaging(0.476) - Thioredoxin_16 - - - -
link to download the report for this variant 196 196 GLN GLU 5a5h_H PDB Neutral none predicted - - 1.279e-05 rs142387037 ENST00000223029 tolerated(0.33) possibly_damaging(0.514) - Thioredoxin_16 7:6062945 7:6023314 81 4.49
link to download the report for this variant 196 196 GLN HIS 5a5h_H PDB Neutral none predicted - - - - - deleterious(0) probably_damaging(0.992) - Thioredoxin_16 - - - -
link to download the report for this variant 200 200 SER ARG 5a5h_H PDB Neutral none predicted - - - rs760513787 ENST00000223029 deleterious(0.04) benign(0.048) Yes Thioredoxin_16 7:6062957 7:6023326 81 4.22
link to download the report for this variant 203 203 THR MET 5a5h_H PDB Neutral none predicted - - 4.58e-05 rs766467029 ENST00000223029 tolerated(0.14) possibly_damaging(0.809) Yes Thioredoxin_16 7:6062967 7:6023336 4 1.19
link to download the report for this variant 204 204 MET THR 5a5h_H PDB Neutral none predicted - - 2.068e-05 rs753779282 ENST00000223029 tolerated(0.1) possibly_damaging(0.892) Yes Thioredoxin_16 7:6062970 7:6023339 9 5.37
link to download the report for this variant 206 206 PRO THR 5a5h_H PDB Neutral none predicted - - - - - deleterious(0) probably_damaging(1) Yes Thioredoxin_16 - - - -
link to download the report for this variant 206 206 PRO SER 5a5h_H PDB Neutral none predicted - - - - - deleterious(0) probably_damaging(1) Yes Thioredoxin_16 - - - -
link to download the report for this variant 208 208 GLU LYS 5a5h_H PDB Neutral none predicted - - 7.394e-05 rs11544566 ENST00000223029 deleterious(0.05) possibly_damaging(0.862) Yes Thioredoxin_16 7:6062981 7:6023350 20 5.37
link to download the report for this variant 209 209 GLY ASP 5a5h_H PDB Damaging Disallowed phi/psi; Gly in a bend - - - rs926430593 ENST00000223029 deleterious(0) probably_damaging(1) Yes - 7:6062985 7:6023354 20 5.37
link to download the report for this variant 210 210 GLU LYS 5a5h_H PDB Damaging Buried charge switch; Buried H-bond breakage; Buried salt bridge breakage - - 2.451e-05 rs756425703 ENST00000223029 deleterious(0) probably_damaging(0.999) - - 7:6062987 7:6023356 44 5.37
link to download the report for this variant 211 211 GLY TRP 5a5h_H PDB Damaging Buried Gly replaced; Buried / exposed switch - - - rs1462376384 ENST00000223029 deleterious(0.01) probably_damaging(0.959) - - 7:6062990 7:6023359 44 5.37
link to download the report for this variant 213 213 ILE THR 5a5h_H PDB Neutral none predicted - - 2.036e-05 rs749728733 ENST00000223029 deleterious(0) probably_damaging(0.948) - - 7:6062997 7:6023366 15 5.37
link to download the report for this variant 214 214 ALA THR 5a5h_H PDB Damaging Cavity altered - - - rs1161751628 ENST00000223029 deleterious(0.01) probably_damaging(0.945) - - 7:6062999 7:6023368 15 5.37
link to download the report for this variant 215 215 ARG CYS 5a5h_H PDB Neutral none predicted - - 1.629e-05 rs377482895 ENST00000223029 deleterious(0) probably_damaging(1) Yes - 7:6063002 7:6023371 0 4.48
link to download the report for this variant 215 215 ARG HIS 5a5h_H PDB Neutral none predicted - - 4.072e-05 rs150887968 ENST00000223029 deleterious(0) probably_damaging(0.999) Yes - 7:6063003 7:6023372 33 5.37
link to download the report for this variant 219 219 SER PRO 5a5h_H PDB Damaging Secondary structure altered - - 1.223e-05 rs150874145 ENST00000223029 tolerated(0.1) probably_damaging(0.935) Yes - 7:6063014 7:6023383 0 5.27
link to download the report for this variant 221 221 PHE SER 5a5h_H PDB Damaging Cavity altered - - 4.078e-06 rs1253653601 ENST00000223029 deleterious(0) possibly_damaging(0.544) - - 7:6063021 7:6023390 0 5.37
link to download the report for this variant 221 221 PHE LEU 5a5h_H PDB Neutral none predicted - - 8.156e-06 rs370941772 ENST00000223029 tolerated(1) benign(0.001) - - 7:6063022 7:6023391 15 0.18
link to download the report for this variant 223 223 GLN ARG 5a5h_H PDB Neutral none predicted - - 8.158e-06 rs760568809 ENST00000223029 tolerated(0.52) benign(0.003) - - 7:6063027 7:6023396 15 4.22
link to download the report for this variant 225 225 HIS ARG 5a5h_H PDB Neutral none predicted - - - rs1209085120 ENST00000223029 tolerated(0.26) benign(0.003) - - 7:6063033 7:6023402 5 5.37
link to download the report for this variant 225 225 HIS TYR 5a5h_H PDB Neutral none predicted - - 4.081e-06 rs369386259 ENST00000223029 tolerated(1) benign(0) - - 7:6063032 7:6023401 5 4.48
link to download the report for this variant 225 225 HIS ASP 5a5h_H PDB Neutral none predicted - - 4.081e-06 rs369386259 ENST00000223029 tolerated(1) benign(0) - - 7:6063032 7:6023401 5 4.48
link to download the report for this variant 225 225 HIS GLN 5a5h_H PDB Neutral none predicted - - - rs776710794 ENST00000223029 tolerated(0.32) benign(0.003) - - 7:6063034 7:6023403 0 -9.86
link to download the report for this variant 226 226 ASN ASP 5a5h_H PDB Neutral none predicted - - 8.166e-06 rs1160411494 ENST00000223029 tolerated(1) benign(0.001) - - 7:6063035 7:6023404 0 -4.16
link to download the report for this variant 226 226 ASN HIS 5a5h_H PDB Neutral none predicted - - 8.166e-06 rs1160411494 ENST00000223029 tolerated(1) benign(0.001) - - 7:6063035 7:6023404 0 -4.16
link to download the report for this variant 226 226 ASN SER 5a5h_H PDB Neutral none predicted - - 0.0001388 rs139398981 ENST00000223029 tolerated(0.1) benign(0.007) - - 7:6063036 7:6023405 1 4.46
link to download the report for this variant 227 227 ALA VAL 5a5h_H PDB Neutral none predicted - - 4.085e-06 rs1310790068 ENST00000223029 tolerated(0.11) benign(0.402) Yes - 7:6063039 7:6023408 1 5.61
link to download the report for this variant 227 227 ALA THR 5a5h_H PDB Neutral none predicted - - 1.226e-05 rs765070549 ENST00000223029 tolerated(0.06) possibly_damaging(0.645) Yes - 7:6063038 7:6023407 0 4.68
link to download the report for this variant 228 228 VAL ALA 5a5h_H PDB Neutral none predicted - - 2.452e-05 rs575274304 ENST00000223029 tolerated(0.28) benign(0.033) Yes - 7:6063042 7:6023411 14 5.61
link to download the report for this variant 228 228 VAL ILE 5a5h_H PDB Neutral none predicted - - 4.086e-06 rs751703423 ENST00000223029 deleterious(0.05) benign(0.207) Yes - 7:6063041 7:6023410 0 3.82
link to download the report for this variant 228 228 VAL LEU 5a5h_H PDB Neutral none predicted - - 4.086e-06 rs751703423 ENST00000223029 deleterious(0.05) benign(0.207) Yes - 7:6063041 7:6023410 0 3.82
link to download the report for this variant 229 229 ASN SER 5a5h_H PDB Neutral none predicted - - - rs1352361945 ENST00000223029 tolerated(0.43) benign(0) - - 7:6063045 7:6023414 14 -6.44
link to download the report for this variant 230 230 ALA THR 5a5h_H PDB Neutral none predicted - - 1.635e-05 rs756474990 ENST00000223029 tolerated(0.43) benign(0.34) Yes - 7:6063047 7:6023416 0 -5.1
link to download the report for this variant 230 230 ALA VAL 5a5h_H PDB Neutral none predicted - - 4.089e-06 rs370354397 ENST00000223029 tolerated(0.12) benign(0.076) Yes - 7:6063048 7:6023417 1 1.99
link to download the report for this variant 232 232 LEU PHE 5a5h_H PDB Neutral none predicted - - 4.091e-06 rs749640780 ENST00000223029 tolerated(0.08) probably_damaging(0.974) Yes - 7:6063053 7:6023422 37 5.61
link to download the report for this variant 232 232 LEU VAL 5a5h_H PDB Neutral none predicted - - 4.091e-06 rs749640780 ENST00000223029 tolerated(0.08) probably_damaging(0.974) Yes - 7:6063053 7:6023422 37 5.61
link to download the report for this variant 235 235 SER GLY 5a5h_H PDB Neutral none predicted - - 2.047e-05 rs374243514 ENST00000223029 tolerated(0.15) benign(0.019) Yes - 7:6063062 7:6023431 4 1.86
link to download the report for this variant 236 236 TRP ARG 5a5h_H PDB Neutral none predicted - - 4.096e-06 rs1041316079 ENST00000223029 deleterious(0) probably_damaging(0.994) - - 7:6063065 7:6023434 1 5.61
link to download the report for this variant 237 237 VAL ALA 5a5h_H PDB Neutral none predicted - - - - - deleterious(0) possibly_damaging(0.743) - - - - - -
link to download the report for this variant 239 239 ILE THR 5a5h_H PDB Neutral none predicted - - 1.229e-05 rs777600343 ENST00000223029 tolerated(0.48) benign(0) Yes - 7:6063075 7:6023444 1 0.73
link to download the report for this variant 239 239 ILE VAL 5a5h_H PDB Neutral none predicted - - 8.194e-05 rs542661636 ENST00000223029 tolerated(1) benign(0) Yes - 7:6063074 7:6023443 0 4.47
link to download the report for this variant 240 240 ALA VAL 5a5h_H PDB Neutral none predicted - - 3.688e-05 rs140208111 ENST00000223029 deleterious(0.02) probably_damaging(1) - - 7:6063078 7:6023447 44 5.61
link to download the report for this variant 240 240 ALA THR 5a5h_H PDB Neutral none predicted - - 4.098e-06 rs1437317399 ENST00000223029 deleterious(0) probably_damaging(1) - - 7:6063077 7:6023446 0 4.73
link to download the report for this variant 243 243 GLN HIS 5a5h_H PDB Neutral none predicted - - 1.23e-05 rs770859885 ENST00000223029 deleterious(0) probably_damaging(0.987) Yes - 7:6063088 7:6023457 37 4.73
link to download the report for this variant 244 244 LEU SER 5a5h_H PDB Neutral none predicted - - - rs1418034441 ENST00000223029 deleterious(0) probably_damaging(0.995) - GST_C 7:6063090 7:6023459 37 5.61
link to download the report for this variant 245 245 LYS GLU 5a5h_H PDB Neutral none predicted - - - rs1174414194 ENST00000223029 tolerated(0.95) benign(0.007) - GST_C 7:6063092 7:6023461 37 4.44
link to download the report for this variant 248 248 SER CYS 5a5h_H PDB Neutral none predicted - - 4.1e-06 rs1360732124 ENST00000223029 deleterious(0) probably_damaging(0.976) - GST_C 7:6063101 7:6023470 1 4.46
link to download the report for this variant 249 249 SER GLY 5a5h_H PDB Neutral none predicted - - 4.101e-06 rs769821226 ENST00000223029 deleterious(0.01) possibly_damaging(0.591) - GST_C 7:6063104 7:6023473 20 4.43
link to download the report for this variant 251 251 GLU GLN 5a5h_H PDB Neutral none predicted - - 4.101e-06 rs1466315276 ENST00000223029 deleterious(0) probably_damaging(0.999) - GST_C 7:6063110 7:6023479 20 5.61
link to download the report for this variant 253 253 ALA SER 5a5h_H PDB Neutral none predicted - - 4.101e-06 rs775245397 ENST00000223029 tolerated(0.07) benign(0.245) - GST_C 7:6063116 7:6023485 4 4.74
link to download the report for this variant 254 254 ALA THR 5a5h_H PDB Neutral none predicted - - 4.102e-06 rs767430426 ENST00000223029 deleterious(0) probably_damaging(0.996) - GST_C 7:6063119 7:6023488 4 4.73
link to download the report for this variant 254 254 ALA PRO 5a5h_H PDB Neutral none predicted - - 4.102e-06 rs767430426 ENST00000223029 deleterious(0) probably_damaging(0.996) - GST_C 7:6063119 7:6023488 4 4.73
link to download the report for this variant 255 255 VAL ILE 5a5h_H PDB Neutral none predicted - - 4.102e-06 rs750657628 ENST00000223029 deleterious(0) probably_damaging(0.916) - GST_C 7:6063122 7:6023491 20 5.51
link to download the report for this variant 256 256 PHE CYS 5a5h_H PDB Neutral none predicted - - - rs1198048843 ENST00000223029 deleterious(0) possibly_damaging(0.662) - GST_C 7:6063126 7:6023495 20 5.51
link to download the report for this variant 257 257 ARG CYS 5a5h_H PDB Neutral none predicted - - 8.205e-06 rs760946189 ENST00000223029 deleterious(0.01) benign(0.056) - GST_C 7:6063128 7:6023497 0 4.62
link to download the report for this variant 257 257 ARG HIS 5a5h_H PDB Neutral none predicted - - 0.0001108 rs145632958 ENST00000223029 deleterious(0) possibly_damaging(0.9) - GST_C 7:6063129 7:6023498 14 5.51
link to download the report for this variant 257 257 ARG LEU 5a5h_H PDB Neutral none predicted - - - - - deleterious(0.01) possibly_damaging(0.791) - GST_C - - - -
link to download the report for this variant 259 259 MET THR 5a5h_H PDB Neutral none predicted - - 8.203e-06 rs1250422075 ENST00000223029 deleterious(0) possibly_damaging(0.647) - GST_C 7:6063135 7:6023504 0 5.61
link to download the report for this variant 259 259 MET ILE 5a5h_H PDB Neutral none predicted - - 4.102e-06 rs375888796 ENST00000223029 deleterious(0.01) benign(0.295) - GST_C 7:6063136 7:6023505 44 4.7
link to download the report for this variant 259 259 MET VAL 5a5h_H PDB Neutral none predicted - - 2.051e-05 rs755273615 ENST00000223029 deleterious(0.01) benign(0.143) - GST_C 7:6063134 7:6023503 0 4.46
link to download the report for this variant 261 261 SER PHE 5a5h_H PDB Neutral none predicted - - - - - deleterious(0) probably_damaging(0.94) - GST_C - - - -
link to download the report for this variant 263 263 LEU VAL 5a5h_H PDB Neutral none predicted - - 4.102e-06 rs757926814 ENST00000223029 deleterious(0) probably_damaging(0.998) - GST_C 7:6063146 7:6023515 9 4.72
link to download the report for this variant 264 264 GLY GLU 5a5h_H PDB Neutral none predicted - - 8.204e-06 rs777357626 ENST00000223029 deleterious(0) probably_damaging(0.993) - GST_C 7:6063150 7:6023519 48 4.72
link to download the report for this variant 266 266 SER ASN 5a5h_H PDB Neutral none predicted - - - rs1490291771 ENST00000223029 tolerated(0.14) benign(0.018) - GST_C 7:6063156 7:6023525 48 4.73
link to download the report for this variant 268 268 TRP GLY 5a5h_H PDB Neutral none predicted - - 4.102e-06 rs1189420601 ENST00000223029 deleterious(0) probably_damaging(0.999) - GST_C 7:6063161 7:6023530 20 5.61
link to download the report for this variant 268 268 TRP SER 5a5h_H PDB Neutral none predicted - - - rs997976538 ENST00000223029 deleterious(0) probably_damaging(0.999) - GST_C 7:6063162 7:6023531 20 5.62
link to download the report for this variant 270 270 ALA THR 5a5h_H PDB Neutral none predicted - - - rs770771902 ENST00000223029 tolerated(0.1) benign(0.015) - GST_C 7:6063167 7:6023536 27 5.62
link to download the report for this variant 270 270 ALA SER 5a5h_H PDB Neutral none predicted - - - rs770771902 ENST00000223029 tolerated(0.1) benign(0.015) - GST_C 7:6063167 7:6023536 27 5.62
link to download the report for this variant 272 272 ASN SER 5a5h_H PDB Neutral none predicted - - 4.102e-06 rs780972148 ENST00000223029 tolerated(1) benign(0.003) - GST_C 7:6063174 7:6023543 48 1.88
link to download the report for this variant 275 275 THR ASN 5a5h_H PDB Neutral none predicted - - - rs1468784875 ENST00000223029 deleterious(0.02) possibly_damaging(0.659) - GST_C 7:6063183 7:6023552 48 4.73
link to download the report for this variant 276 276 VAL ILE 5a5h_H PDB Neutral none predicted - - 0.0003282 rs147246097 ENST00000223029 tolerated(0.11) benign(0.254) - GST_C 7:6063185 7:6023554 37 5.62
link to download the report for this variant 279 279 VAL GLY 5a5h_H PDB Neutral none predicted - - - rs1160401203 ENST00000223029 deleterious(0) possibly_damaging(0.806) - GST_C 7:6063195 7:6023564 20 5.62
link to download the report for this variant 279 279 VAL MET 5a5h_H PDB Neutral none predicted - - 2.051e-05 rs374123170 ENST00000223029 deleterious(0.03) benign(0.32) - GST_C 7:6063194 7:6023563 20 2.46
link to download the report for this variant 280 280 VAL MET 5a5h_H PDB Neutral none predicted - - - rs893082791 ENST00000223029 deleterious(0.01) probably_damaging(0.919) - GST_C 7:6063197 7:6023566 20 4.74
link to download the report for this variant 281 281 LEU VAL 5a5h_H PDB Neutral none predicted - - - rs1368842334 ENST00000223029 tolerated(0.25) benign(0.029) - GST_C 7:6063200 7:6023569 0 0.2
link to download the report for this variant 281 281 LEU PRO 5a5h_H PDB Damaging Buried Pro introduced - - 8.204e-06 rs773350468 ENST00000223029 tolerated(0.15) possibly_damaging(0.663) - GST_C 7:6063201 7:6023570 4 4.49
link to download the report for this variant 282 282 TRP SER 5a5h_H PDB Neutral none predicted - - 4.102e-06 rs760716532 ENST00000223029 deleterious(0) possibly_damaging(0.835) - GST_C 7:6063204 7:6023573 4 5.62
link to download the report for this variant 283 283 SER PHE 5a5h_H PDB Damaging Buried H-bond breakage - - 4.102e-06 rs754007971 ENST00000223029 deleterious(0.04) possibly_damaging(0.65) - GST_C 7:6063207 7:6023576 1 4.73
link to download the report for this variant 284 284 VAL LEU 5a5h_H PDB Neutral none predicted - - 4.102e-06 rs759973375 ENST00000223029 tolerated(0.09) benign(0.054) - GST_C 7:6063209 7:6023578 4 5.62
link to download the report for this variant 284 284 VAL ILE 5a5h_H PDB Neutral none predicted - - 4.102e-06 rs759973375 ENST00000223029 tolerated(0.09) benign(0.054) - GST_C 7:6063209 7:6023578 4 5.62
link to download the report for this variant 284 284 VAL ALA 5a5h_H PDB Neutral none predicted - - - rs1374586427 ENST00000223029 tolerated(0.88) benign(0) - GST_C 7:6063210 7:6023579 4 0.79
link to download the report for this variant 285 285 LEU PHE 5a5h_H PDB Neutral none predicted - - 1.231e-05 rs765449737 ENST00000223029 deleterious(0.01) possibly_damaging(0.806) - GST_C 7:6063212 7:6023581 9 4.75
link to download the report for this variant 286 286 GLN ARG 5a5h_H PDB Neutral none predicted - - 9.435e-05 rs758885310 ENST00000223029 tolerated(0.94) benign(0) - GST_C 7:6063216 7:6023585 9 3.25
link to download the report for this variant 287 287 GLN PRO 5a5h_H PDB Damaging Secondary structure altered; Cavity altered - - - rs1477363279 ENST00000223029 deleterious(0) possibly_damaging(0.887) - GST_C 7:6063219 7:6023588 0 4.46
link to download the report for this variant 287 287 GLN HIS 5a5h_H PDB Damaging Cavity altered - - 7.383e-05 rs189587013 ENST00000223029 deleterious(0.01) probably_damaging(0.94) - GST_C 7:6063220 7:6023589 0 3.79
link to download the report for this variant 288 288 ILE PHE 5a5h_H PDB Neutral none predicted - - - rs751152417 ENST00000223029 deleterious(0) benign(0.003) - GST_C 7:6063221 7:6023590 4 -2.26
link to download the report for this variant 288 288 ILE VAL 5a5h_H PDB Neutral none predicted - - - rs751152417 ENST00000223029 deleterious(0) benign(0.003) - GST_C 7:6063221 7:6023590 4 -2.26
link to download the report for this variant 289 289 GLY ARG 5a5h_H PDB Neutral none predicted - - 6.973e-05 rs745445513 ENST00000223029 deleterious(0.01) probably_damaging(0.998) - GST_C 7:6063224 7:6023593 53 5.61
link to download the report for this variant 291 291 CYS TRP 5a5h_H PDB Damaging Clash - - - - - deleterious(0.01) possibly_damaging(0.498) - GST_C - - - -
link to download the report for this variant 291 291 CYS PHE 5a5h_H PDB Neutral none predicted - - - - - deleterious(0.02) benign(0.167) - GST_C - - - -
link to download the report for this variant 292 292 SER GLY 5a5h_H PDB Neutral none predicted - - 0.0002 rs565466567 ENST00000223029 tolerated(0.26) benign(0) - GST_C 7:6063233 7:6023602 53 -1.29
link to download the report for this variant 293 293 VAL MET 5a5h_H PDB Neutral none predicted - - 4.102e-06 rs1417372255 ENST00000223029 deleterious(0.04) benign(0.001) - GST_C 7:6063236 7:6023605 20 1.51
link to download the report for this variant 295 295 VAL LEU 5a5h_H PDB Neutral none predicted - - 4.102e-06 rs749107344 ENST00000223029 tolerated(0.11) benign(0.079) - GST_C 7:6063242 7:6023611 9 5.35
link to download the report for this variant 295 295 VAL MET 5a5h_H PDB Neutral none predicted - - 4.102e-06 rs749107344 ENST00000223029 tolerated(0.11) benign(0.079) - GST_C 7:6063242 7:6023611 9 5.35
link to download the report for this variant 296 296 PRO LEU 5a5h_H PDB Neutral none predicted - - 8.203e-06 rs1022792814 ENST00000223029 deleterious(0) probably_damaging(0.999) - GST_C 7:6063246 7:6023615 1 5.35
link to download the report for this variant 297 297 ALA GLY 5a5h_H PDB Neutral none predicted - - 8.203e-06 rs371505435 ENST00000223029 tolerated(0.06) benign(0.258) - GST_C 7:6063249 7:6023618 9 4.47
link to download the report for this variant 297 297 ALA SER 5a5h_H PDB Neutral none predicted - - 4.102e-06 rs768623646 ENST00000223029 tolerated(0.23) benign(0.017) - GST_C 7:6063248 7:6023617 9 3.5
link to download the report for this variant 298 298 ASN SER 5a5h_H PDB Neutral none predicted - - 1.23e-05 rs1296854295 ENST00000223029 tolerated(0.05) benign(0.067) - GST_C 7:6063252 7:6023621 32 2.71
link to download the report for this variant 301 301 ARG GLY 5a5h_H PDB Neutral none predicted - - 4.102e-06 rs1400949174 ENST00000223029 deleterious(0) benign(0.217) - GST_C 7:6063260 7:6023629 20 2.85
link to download the report for this variant 303 303 MET VAL 5a5h_H PDB Neutral none predicted - - 4.101e-06 rs1278445417 ENST00000223029 tolerated(0.25) benign(0.003) - GST_C 7:6063266 7:6023635 1 0.22
link to download the report for this variant 303 303 MET ILE 5a5h_H PDB Neutral none predicted - - 8.203e-06 rs375897273 ENST00000223029 tolerated(0.42) benign(0) - GST_C 7:6063268 7:6023637 32 2.48
link to download the report for this variant 304 304 ARG LYS 5a5h_H PDB Neutral none predicted - - - rs1450412066 ENST00000223029 tolerated(1) benign(0) - GST_C 7:6063270 7:6023639 32 -0.34
link to download the report for this variant 306 306 CYS TYR 5a5h_H PDB Damaging Clash - - 8.204e-06 rs1291481810 ENST00000223029 deleterious(0) probably_damaging(0.999) - - 7:6063276 7:6023645 0 5.35
link to download the report for this variant 306 306 CYS TRP 5a5h_H PDB Damaging Clash; Buried H-bond breakage - - 4.102e-06 rs368862792 ENST00000223029 deleterious(0) probably_damaging(1) - - 7:6063277 7:6023646 27 0.39
link to download the report for this variant 309 309 LEU VAL 5a5h_H PDB Neutral none predicted - - 4.102e-06 rs1283740223 ENST00000223029 deleterious(0.03) probably_damaging(0.963) - - 7:6063284 7:6023653 4 4.46
link to download the report for this variant 310 310 ALA GLY 5a5h_H PDB Neutral none predicted - - 8.205e-06 rs1194037382 ENST00000223029 tolerated(0.43) benign(0.006) - - 7:6063288 7:6023657 20 4.47
link to download the report for this variant 310 310 ALA THR 5a5h_H PDB Neutral none predicted - - 4.102e-06 rs765484017 ENST00000223029 deleterious(0.02) benign(0.167) - - 7:6063287 7:6023656 0 5.35
link to download the report for this variant 312 312 PHE SER 5a5h_H PDB Neutral none predicted - - 4.102e-06 rs1257101048 ENST00000223029 deleterious(0) probably_damaging(0.949) - - 7:6063294 7:6023663 1 4.2
link to download the report for this variant 313 313 ASN HIS 5a5h_H PDB Neutral none predicted - - 4.102e-06 rs1471966476 ENST00000223029 tolerated(0.29) benign(0.003) - - 7:6063296 7:6023665 9 2.95
link to download the report for this variant 314 314 THR MET 5a5h_H PDB Neutral none predicted - - 6.975e-05 rs372238513 ENST00000223029 tolerated(0.18) possibly_damaging(0.505) - - 7:6063300 7:6023669 1 1.3
link to download the report for this variant 316 316 LEU PHE 5a5h_H PDB Neutral none predicted - - - rs751316385 ENST00000223029 tolerated(0.07) possibly_damaging(0.751) - - 7:6063305 7:6023674 20 2.43
link to download the report for this variant 316 316 LEU VAL 5a5h_H PDB Neutral none predicted - - - rs751316385 ENST00000223029 tolerated(0.07) possibly_damaging(0.751) - - 7:6063305 7:6023674 20 2.43
link to download the report for this variant 318 318 LEU PHE 5a5h_H PDB Neutral none predicted - - 1.23e-05 rs1420707837 ENST00000223029 tolerated(0.18) benign(0.054) - - 7:6063311 7:6023680 20 3.56
link to download the report for this variant 320 320 LYS MET 5a5h_F PDB Neutral none predicted - - - rs1236532294 ENST00000223029 deleterious_low_confidence(0) possibly_damaging(0.694) - - 7:6063318 7:6023687 0 5.35
link to download the report for this variant 320 320 LYS GLN 5a5h_F PDB Neutral none predicted - - 4.1e-06 rs1445406759 ENST00000223029 tolerated_low_confidence(0.7) benign(0.009) - - 7:6063317 7:6023686 1 -3.74
link to download the report for this variant 320 320 LYS ASN 5a5h_F PDB Neutral none predicted - - 1.23e-05 rs79993082 ENST00000223029 deleterious_low_confidence(0.01) benign(0.265) - - 7:6063319 7:6023688 9 5.35
link to download the report for this variant 150 150 SER PRO 5a5h_H PDB Neutral none predicted - - 1.223e-05 rs150874145 ENST00000395236 tolerated(0.16) possibly_damaging(0.905) - Thioredoxin_16 7:6063014 7:6023383 0 5.27


If your variant is not present in the Missense3D-DB you can produce your own variant analysis using our Missense3D website and your own 3D structural model by clicking here.



Missense3D-DB is free for academic and commercial users.

Please see the Missense3D-DB Licence, Disclaimer and Terms and Conditions of Use by clicking on this link.

If you use Missense3D-DB please click here to see how to cite Missense3D-DB

version 1.5.4 22/11/22