Missense3D-DB results

(structural effect of missense variants)

Note: In this version of the database, the structural analysis is based on the impact of a variant on the protein tertiary structure. The missense variant may disrupt additional features (e.g. protein-protein interactions or functional sites) that we are currently not capturing.

UniProt ID: Q9HCU0     Gene name: CD248     pLI score: 0.54 tooltip info, click for explanation of pLI score     RVIS score: 1.09 (88.0 %) tooltip info, click for explanation of RVIS scores

tooltip info, click on the Download Report checkbox to display the column which supports the download of a custom report in the results table    tooltip info, click on the UniProt Position checkbox to display the uniprot position column in the results table    tooltip info, click on the PDB/Model Position checkbox to display the PDB or Model position column in the results table    tooltip info, click on the Residue Wildtype checkbox to display the wildtype residue column in the results table    tooltip info, click on the Residue Mutant checkbox to display the mutant residue column in the results table    tooltip info, click on the Structure checkbox to display the PDB/structure id column in the results table    tooltip info, click on the Structure Type checkbox to display the PDB/Phyre model column in the results table    tooltip info, click on the Missense3D Prediction checkbox to display the Missense3D Prediction column in the results table    tooltip info, click on the Structural damage predicted checkbox to display the column detailing whether structural damage is predicted in the results table    tooltip info, click on the Humsavar annotation checkbox to display the Humsavar annotation column in the results table    tooltip info, click on the ClinVar annotation checkbox to display the ClinVar annotation column in the results table    tooltip info, click on the MAF score checkbox to display the MAF score column in the results table    tooltip info, click on the dbSNP checkbox to display the dbSNP id column in the results table    tooltip info, click on the Ensemble ID checkbox to display the Ensemble ID column in the results table    tooltip info, click on the SIFT prediction(score) checkbox to display the SIFT prediction and score column in the results table    tooltip info, click on the PolyPhen-2 prediction(score) checkbox to display the PolyPhen-2 prediction and score column in the results table    tooltip info, click on the Interface(source RCSB) checkbox to display the Interface column in the results table    tooltip info, click on the Pfam domain checkbox to display the Pfam domain id column in the results table    tooltip info, click on the Location (GRCh37) checkbox to display the column containing the GRCh37 Chromosome location in the results table    tooltip info, click on the Location (GRCh38) checkbox to display the column containing the GRCh38 Chromosome location in the results table    tooltip info, click on the CCR percentile checkbox to display the conserved coding region percentile column in the results table    tooltip info, click on the GERP score checkbox to display the GERP score column in the results table

If your variant is not present in the table below click here to use our missense3d website to analyse it using your own 3D structural model.

Download Report Uniprot Position PDB/Model Position Residue Wildtype Residue Mutant Structure Structure Type Missense3D Prediction Structural damage predicted Humsavar Annotation ClinVar Annotation MAF score dbSNP Ensemble ID SIFT prediction(score) PolyPhen-2 prediction(score) Interface(source RCSB) Pfam domain Location (GRCh37) Location (GRCh38) CCR percentile GERP score
link to download the report for this variant 24 24 GLU ASP 3KQG_B MODEL Neutral none predicted - - 6.495e-06 rs745851281 ENST00000311330 deleterious(0.01) benign(0.239) - - 11:66084427 11:66316956 43 2.69
link to download the report for this variant 25 25 PRO ALA 3KQG_B MODEL Neutral none predicted - - 1.274e-05 rs776398088 ENST00000311330 tolerated(0.07) benign(0.003) - - 11:66084426 11:66316955 43 2.6
link to download the report for this variant 26 26 ARG HIS 3KQG_B MODEL Neutral none predicted - - 1.26e-05 rs748162950 ENST00000311330 tolerated(0.17) benign(0) - - 11:66084422 11:66316951 1 0.3
link to download the report for this variant 26 26 ARG CYS 3KQG_B MODEL Neutral none predicted - - 1.253e-05 rs772257351 ENST00000311330 deleterious(0.01) possibly_damaging(0.451) - - 11:66084423 11:66316952 1 1.46
link to download the report for this variant 27 27 ALA PRO 3KQG_B MODEL Neutral none predicted - - - rs779208370 ENST00000311330 deleterious(0) possibly_damaging(0.47) - - 11:66084420 11:66316949 1 1.98
link to download the report for this variant 27 27 ALA SER 3KQG_B MODEL Neutral none predicted - - - rs779208370 ENST00000311330 deleterious(0) possibly_damaging(0.47) - - 11:66084420 11:66316949 1 1.98
link to download the report for this variant 27 27 ALA GLY 3KQG_B MODEL Neutral none predicted - - 6.137e-06 rs1483420284 ENST00000311330 tolerated(0.1) benign(0.156) - - 11:66084419 11:66316948 1 3.94
link to download the report for this variant 28 28 ALA THR 3KQG_B MODEL Neutral none predicted - - 3.092e-05 rs754821906 ENST00000311330 tolerated(0.34) benign(0) - - 11:66084417 11:66316946 47 -1.44
link to download the report for this variant 28 28 ALA SER 3KQG_B MODEL Neutral none predicted - - 3.092e-05 rs754821906 ENST00000311330 tolerated(0.34) benign(0) - - 11:66084417 11:66316946 47 -1.44
link to download the report for this variant 30 30 GLY ARG 3KQG_B MODEL Damaging Buried Gly replaced; Buried / exposed switch - - 0.0 rs988740385 ENST00000311330 tolerated(0.15) benign(0.095) - - 11:66084411 11:66316940 47 3.94
link to download the report for this variant 30 30 GLY SER 3KQG_B MODEL Damaging Buried Gly replaced - - 0.0 rs988740385 ENST00000311330 tolerated(0.15) benign(0.095) - - 11:66084411 11:66316940 47 3.94
link to download the report for this variant 31 31 PRO HIS 5AO5_A MODEL Neutral none predicted - - - rs935997785 ENST00000311330 deleterious(0.01) possibly_damaging(0.533) - - 11:66084407 11:66316936 47 3.02
link to download the report for this variant 32 32 SER GLY 5AO5_A MODEL Neutral none predicted - - 1.786e-05 rs750980250 ENST00000311330 tolerated(0.81) benign(0) - - 11:66084405 11:66316934 47 -3.29
link to download the report for this variant 33 33 SER ASN 5AO5_A MODEL Neutral none predicted - - 5.924e-06 rs910536773 ENST00000311330 tolerated(0.08) benign(0.261) - - 11:66084401 11:66316930 47 3.94
link to download the report for this variant 38 38 PHE LEU 5AO5_A MODEL Neutral none predicted - - 0.0002072 rs761497628 ENST00000311330 deleterious(0.02) benign(0.115) - - 11:66084385 11:66316914 26 1.67
link to download the report for this variant 39 39 PRO LEU 5AO5_A MODEL Neutral none predicted - - 5.79e-06 rs1396980005 ENST00000311330 tolerated(0.56) benign(0.015) - - 11:66084383 11:66316912 13 2.61
link to download the report for this variant 40 40 ARG TRP 5AO5_A MODEL Neutral none predicted - - 1.167e-05 rs750979307 ENST00000311330 deleterious(0) possibly_damaging(0.541) - - 11:66084381 11:66316910 13 0.23
link to download the report for this variant 40 40 ARG GLN 5AO5_A MODEL Neutral none predicted - - 5.87e-06 rs1296610311 ENST00000311330 tolerated(1) benign(0.003) - - 11:66084380 11:66316909 13 -0.45
link to download the report for this variant 41 41 ARG CYS 5AO5_A MODEL Neutral none predicted - - 5.891e-06 rs763743989 ENST00000311330 deleterious(0) probably_damaging(0.95) - - 11:66084378 11:66316907 13 2.72
link to download the report for this variant 41 41 ARG HIS 5AO5_A MODEL Neutral none predicted - - - rs1361299575 ENST00000311330 deleterious(0.03) probably_damaging(0.95) - - 11:66084377 11:66316906 13 2.68
link to download the report for this variant 41 41 ARG PRO 5AO5_A MODEL Neutral none predicted - - - rs1361299575 ENST00000311330 deleterious(0.03) probably_damaging(0.95) - - 11:66084377 11:66316906 13 2.68
link to download the report for this variant 42 42 ARG CYS 5AO5_A MODEL Neutral none predicted - - 4.735e-05 rs551979045 ENST00000311330 deleterious(0.02) possibly_damaging(0.873) - Lectin_C 11:66084375 11:66316904 13 2.65
link to download the report for this variant 42 42 ARG HIS 5AO5_A MODEL Neutral none predicted - - 0.001216 rs199630152 ENST00000311330 deleterious(0.01) benign(0.043) - Lectin_C 11:66084374 11:66316903 13 2.71
link to download the report for this variant 43 43 THR ASN 5AO5_A MODEL Neutral none predicted - - - rs1361343966 ENST00000311330 deleterious(0.04) possibly_damaging(0.675) - Lectin_C 11:66084371 11:66316900 67 3.63
link to download the report for this variant 46 46 GLU ALA 5AO5_A MODEL Neutral none predicted - - - rs1280367060 ENST00000311330 deleterious(0.04) benign(0.207) - Lectin_C 11:66084362 11:66316891 67 3.63
link to download the report for this variant 47 47 ALA ASP 5AO5_A MODEL Damaging Buried hydrophilic introduced; Buried charge introduced - - - rs1198541727 ENST00000311330 deleterious(0) probably_damaging(0.991) - Lectin_C 11:66084359 11:66316888 67 3.63
link to download the report for this variant 49 49 ARG TRP 5AO5_A MODEL Neutral none predicted - - 2.554e-05 rs759244619 ENST00000311330 deleterious(0) probably_damaging(0.98) - Lectin_C 11:66084354 11:66316883 67 2.5
link to download the report for this variant 50 50 ALA ASP 5AO5_A MODEL Neutral none predicted - - 1.302e-05 rs776687059 ENST00000311330 deleterious(0.01) possibly_damaging(0.759) - Lectin_C 11:66084350 11:66316879 0 3.63
link to download the report for this variant 52 52 ARG HIS 5AO5_A MODEL Neutral none predicted - - 0.001584 rs185191470 ENST00000311330 deleterious(0) probably_damaging(0.984) - Lectin_C 11:66084344 11:66316873 0 3.64
link to download the report for this variant 52 52 ARG GLY 5AO5_A MODEL Neutral none predicted - - 6.493e-06 rs1214059157 ENST00000311330 deleterious(0) probably_damaging(0.97) - Lectin_C 11:66084345 11:66316874 4 3.64
link to download the report for this variant 52 52 ARG CYS 5AO5_A MODEL Neutral none predicted - - 6.493e-06 rs1214059157 ENST00000311330 deleterious(0) probably_damaging(0.97) - Lectin_C 11:66084345 11:66316874 4 3.64
link to download the report for this variant 53 53 GLU ASP 5AO5_A MODEL Neutral none predicted - - 5.799e-05 rs749572714 ENST00000311330 tolerated(0.12) benign(0.046) - Lectin_C 11:66084340 11:66316869 0 -2.16
link to download the report for this variant 53 53 GLU LYS 5AO5_A MODEL Neutral none predicted - - 3.926e-05 rs769023822 ENST00000311330 tolerated(0.06) benign(0.033) - Lectin_C 11:66084342 11:66316871 0 2.72
link to download the report for this variant 54 54 LEU PRO 5AO5_A MODEL Damaging Clash - - 0.0002 rs549922332 ENST00000311330 tolerated(0.11) probably_damaging(0.944) - Lectin_C 11:66084338 11:66316867 8 3.75
link to download the report for this variant 55 55 GLY ARG 5AO5_A MODEL Neutral none predicted - - - rs569670324 ENST00000311330 deleterious(0.03) probably_damaging(0.997) - Lectin_C 11:66084336 11:66316865 8 3.75
link to download the report for this variant 55 55 GLY ALA 5AO5_A MODEL Neutral none predicted - - 6.351e-06 rs1286501110 ENST00000311330 deleterious(0) probably_damaging(0.994) - Lectin_C 11:66084335 11:66316864 8 3.75
link to download the report for this variant 56 56 GLY ASP 5AO5_A MODEL Neutral none predicted - - 6.442e-06 rs1246110246 ENST00000311330 deleterious(0) probably_damaging(0.977) - Lectin_C 11:66084332 11:66316861 8 3.75
link to download the report for this variant 57 57 ASP GLU 5AO5_A MODEL Neutral none predicted - - - rs756614260 ENST00000311330 deleterious(0.01) benign(0.038) - Lectin_C 11:66084328 11:66316857 31 3.75
link to download the report for this variant 57 57 ASP ASN 5AO5_A MODEL Neutral none predicted - - 6.384e-06 rs1340355370 ENST00000311330 tolerated(1) benign(0) - Lectin_C 11:66084330 11:66316859 0 -5.4
link to download the report for this variant 59 59 ALA THR 5AO5_A MODEL Neutral none predicted - - - rs1335778327 ENST00000311330 deleterious(0) probably_damaging(0.942) - Lectin_C 11:66084324 11:66316853 31 2.82
link to download the report for this variant 60 60 THR SER 5AO5_A MODEL Neutral none predicted - - 5.959e-06 rs746208789 ENST00000311330 deleterious(0.01) probably_damaging(0.983) - Lectin_C 11:66084320 11:66316849 31 3.75
link to download the report for this variant 62 62 ARG GLN 5AO5_A MODEL Neutral none predicted - - - rs1394972132 ENST00000311330 deleterious(0.01) benign(0.015) - Lectin_C 11:66084314 11:66316843 43 1.65
link to download the report for this variant 63 63 THR ILE 5AO5_A MODEL Neutral none predicted - - 0.0 rs902928165 ENST00000311330 tolerated(0.07) benign(0.037) - Lectin_C 11:66084311 11:66316840 43 2.84
link to download the report for this variant 64 64 PRO ALA 5AO5_A MODEL Neutral none predicted - - - rs1314813523 ENST00000311330 tolerated(0.35) possibly_damaging(0.5) - Lectin_C 11:66084309 11:66316838 43 3.75
link to download the report for this variant 65 65 GLU LYS 5AO5_A MODEL Neutral none predicted - - 5.545e-06 rs757640463 ENST00000311330 deleterious(0.04) benign(0.041) - Lectin_C 11:66084306 11:66316835 43 3.75
link to download the report for this variant 69 69 ARG LEU 5AO5_A MODEL Neutral none predicted - - 7.26e-05 rs751114440 ENST00000311330 tolerated(0.15) possibly_damaging(0.615) - Lectin_C 11:66084293 11:66316822 47 2.83
link to download the report for this variant 69 69 ARG HIS 5AO5_A MODEL Neutral none predicted - - 7.26e-05 rs751114440 ENST00000311330 tolerated(0.15) possibly_damaging(0.615) - Lectin_C 11:66084293 11:66316822 47 2.83
link to download the report for this variant 72 72 SER ASN 5AO5_A MODEL Neutral none predicted - - 0.008481 rs111751859 ENST00000311330 tolerated(0.18) benign(0) - Lectin_C 11:66084284 11:66316813 31 0.45
link to download the report for this variant 76 76 ALA VAL 5AO5_A MODEL Neutral none predicted - - - rs1427912415 ENST00000311330 tolerated(0.07) benign(0.009) - Lectin_C 11:66084272 11:66316801 0 1.73
link to download the report for this variant 76 76 ALA PRO 5AO5_A MODEL Damaging Secondary structure altered; Disallowed phi/psi - - 9.679e-06 rs1263460307 ENST00000311330 tolerated(0.09) benign(0.005) - Lectin_C 11:66084273 11:66316802 43 -0.9
link to download the report for this variant 77 77 GLY SER 5AO5_A MODEL Damaging Disallowed phi/psi; Gly in a bend - - 1.442e-05 rs764852635 ENST00000311330 tolerated(0.45) benign(0.023) - Lectin_C 11:66084270 11:66316799 0 0.71
link to download the report for this variant 78 78 PRO SER 5AO5_A MODEL Neutral none predicted - - 0.0 rs1291378616 ENST00000311330 tolerated(0.19) benign(0.001) - Lectin_C 11:66084267 11:66316796 52 1.72
link to download the report for this variant 81 81 ARG TRP 5AO5_A MODEL Neutral none predicted - - 4.675e-06 rs541032235 ENST00000311330 deleterious(0.02) possibly_damaging(0.683) - Lectin_C 11:66084258 11:66316787 52 -1.52
link to download the report for this variant 81 81 ARG GLN 5AO5_A MODEL Neutral none predicted - - 2.323e-05 rs759387574 ENST00000311330 tolerated(0.35) benign(0.01) - Lectin_C 11:66084257 11:66316786 52 -1.11
link to download the report for this variant 84 84 TRP LEU 5AO5_A MODEL Neutral none predicted - - 0.0 rs1220860606 ENST00000311330 deleterious(0) benign(0.206) - Lectin_C 11:66084248 11:66316777 79 3.12
link to download the report for this variant 86 86 GLY ARG 5AO5_A MODEL Damaging Buried charge introduced; Buried Gly replaced - - 4.57e-06 rs766369427 ENST00000311330 deleterious(0) probably_damaging(1) - Lectin_C 11:66084243 11:66316772 79 4.05
link to download the report for this variant 87 87 LEU MET 5AO5_A MODEL Neutral none predicted - - 4.66e-05 rs760481697 ENST00000311330 deleterious(0) probably_damaging(0.999) - Lectin_C 11:66084240 11:66316769 79 2.14
link to download the report for this variant 89 89 ARG TRP 5AO5_A MODEL Neutral none predicted - - 0.000154 rs768897237 ENST00000311330 deleterious(0) probably_damaging(1) - Lectin_C 11:66084234 11:66316763 79 3.1
link to download the report for this variant 89 89 ARG LEU 5AO5_A MODEL Neutral none predicted - - 0.0 rs763121760 ENST00000311330 deleterious(0) probably_damaging(0.999) - Lectin_C 11:66084233 11:66316762 79 4.05
link to download the report for this variant 89 89 ARG GLN 5AO5_A MODEL Neutral none predicted - - 0.0 rs763121760 ENST00000311330 deleterious(0) probably_damaging(0.999) - Lectin_C 11:66084233 11:66316762 79 4.05
link to download the report for this variant 91 91 ALA VAL 5AO5_A MODEL Neutral none predicted - - 9.125e-06 rs775916636 ENST00000311330 deleterious(0.01) possibly_damaging(0.457) - Lectin_C 11:66084227 11:66316756 19 3.96
link to download the report for this variant 92 92 ARG TRP 5AO5_A MODEL Neutral none predicted - - 1.352e-05 rs565411308 ENST00000311330 deleterious(0) probably_damaging(0.999) - Lectin_C 11:66084225 11:66316754 1 3.03
link to download the report for this variant 92 92 ARG GLN 5AO5_A MODEL Neutral none predicted - - 4.537e-06 rs746250707 ENST00000311330 deleterious(0) probably_damaging(0.996) - Lectin_C 11:66084224 11:66316753 0 3.96
link to download the report for this variant 94 94 CYS TYR 5AO5_A MODEL Neutral none predicted - - 0.0002062 rs199828803 ENST00000311330 deleterious(0) probably_damaging(0.997) - Lectin_C 11:66084218 11:66316747 26 3.96
link to download the report for this variant 96 96 LEU PRO 5AO5_A MODEL Damaging Disallowed phi/psi - - - rs1252823600 ENST00000311330 tolerated(1) benign(0) - Lectin_C 11:66084212 11:66316741 52 1.93
link to download the report for this variant 98 98 ARG HIS 5AO5_A MODEL Neutral none predicted - - 4.416e-06 rs747508669 ENST00000311330 deleterious(0) probably_damaging(0.984) - Lectin_C 11:66084206 11:66316735 52 3.96
link to download the report for this variant 98 98 ARG CYS 5AO5_A MODEL Neutral none predicted - - 1.772e-05 rs763690833 ENST00000311330 deleterious(0) probably_damaging(0.993) - Lectin_C 11:66084207 11:66316736 52 3.96
link to download the report for this variant 99 99 PRO SER 5AO5_A MODEL Neutral none predicted - - 4.406e-06 rs1236884440 ENST00000311330 tolerated(0.06) probably_damaging(0.994) - Lectin_C 11:66084204 11:66316733 52 3.96
link to download the report for this variant 101 101 ARG CYS 5AO5_A MODEL Neutral none predicted - - 0.0 rs1201027563 ENST00000311330 deleterious(0) probably_damaging(1) - Lectin_C 11:66084198 11:66316727 51 3.96
link to download the report for this variant 102 102 GLY SER 5AO5_A MODEL Neutral none predicted - - 0.0 rs1278331560 ENST00000311330 deleterious(0) probably_damaging(1) - Lectin_C 11:66084195 11:66316724 51 3.96
link to download the report for this variant 104 104 THR MET 5AO5_A MODEL Neutral none predicted - - 8.718e-06 rs778542077 ENST00000311330 deleterious(0.04) possibly_damaging(0.708) - Lectin_C 11:66084188 11:66316717 0 3.02
link to download the report for this variant 104 104 THR ALA 5AO5_A MODEL Neutral none predicted - - 1.307e-05 rs780403655 ENST00000311330 deleterious(0.03) benign(0.19) - Lectin_C 11:66084189 11:66316718 51 3.96
link to download the report for this variant 105 105 TRP ARG 5AO5_A MODEL Neutral none predicted - - 4.349e-06 rs753687806 ENST00000311330 deleterious(0) probably_damaging(0.999) - Lectin_C 11:66084186 11:66316715 0 3.96
link to download the report for this variant 106 106 THR ILE 5AO5_A MODEL Neutral none predicted - - 0.0 rs1329257564 ENST00000311330 tolerated(0.14) benign(0.251) - Lectin_C 11:66084182 11:66316711 43 3.04
link to download the report for this variant 108 108 GLY GLU 5AO5_A MODEL Damaging Disallowed phi/psi - - 8.66e-06 rs1412464152 ENST00000311330 deleterious(0) probably_damaging(0.998) - Lectin_C 11:66084176 11:66316705 43 3.96
link to download the report for this variant 108 108 GLY ARG 5AO5_A MODEL Damaging Disallowed phi/psi - - 4.335e-06 rs750452631 ENST00000311330 deleterious(0) probably_damaging(0.966) - Lectin_C 11:66084177 11:66316706 43 3.96
link to download the report for this variant 109 109 ASP GLU 5AO5_A MODEL Neutral none predicted - - 4.335e-06 rs1426848971 ENST00000311330 tolerated(0.11) probably_damaging(0.99) - Lectin_C 11:66084172 11:66316701 9 3.96
link to download the report for this variant 112 112 THR ARG 5AO5_A MODEL Neutral none predicted - - 4.33e-06 rs1016367945 ENST00000311330 deleterious(0) probably_damaging(0.995) - Lectin_C 11:66084164 11:66316693 31 3.96
link to download the report for this variant 112 112 THR MET 5AO5_A MODEL Neutral none predicted - - 4.33e-06 rs1016367945 ENST00000311330 deleterious(0) probably_damaging(0.995) - Lectin_C 11:66084164 11:66316693 31 3.96
link to download the report for this variant 112 112 THR SER 5AO5_A MODEL Neutral none predicted - - - rs1295246512 ENST00000311330 deleterious(0) probably_damaging(0.953) - Lectin_C 11:66084165 11:66316694 31 3.96
link to download the report for this variant 113 113 ALA THR 5AO5_A MODEL Neutral none predicted - - 8.667e-05 rs373841229 ENST00000311330 tolerated(0.2) probably_damaging(0.977) - Lectin_C 11:66084162 11:66316691 1 3.96
link to download the report for this variant 115 115 THR ASN 5AO5_A MODEL Neutral none predicted - - - - - deleterious(0.03) probably_damaging(0.993) - Lectin_C - - - -
link to download the report for this variant 115 115 THR ALA 5AO5_A MODEL Neutral none predicted - - 0.002029 rs75789995 ENST00000311330 deleterious(0) probably_damaging(0.976) - Lectin_C 11:66084156 11:66316685 19 3.96
link to download the report for this variant 116 116 ASN SER 5AO5_A MODEL Neutral none predicted - - 4.337e-06 rs770088737 ENST00000311330 deleterious(0) probably_damaging(0.983) - Lectin_C 11:66084152 11:66316681 4 3.96
link to download the report for this variant 118 118 ALA VAL 5AO5_A MODEL Neutral none predicted - - 8.684e-06 rs1279642756 ENST00000311330 deleterious(0.04) possibly_damaging(0.859) - Lectin_C 11:66084146 11:66316675 60 3.96
link to download the report for this variant 119 119 GLN HIS 5AO5_A MODEL Neutral none predicted - - 3.043e-05 rs771265389 ENST00000311330 deleterious(0.02) benign(0.029) - Lectin_C 11:66084142 11:66316671 60 3.01
link to download the report for this variant 120 120 PRO SER 5AO5_A MODEL Neutral none predicted - - 4.345e-06 rs747356569 ENST00000311330 deleterious(0.04) benign(0.196) - Lectin_C 11:66084141 11:66316670 60 3.96
link to download the report for this variant 120 120 PRO ARG 5AO5_A MODEL Neutral none predicted - - - rs1311518287 ENST00000311330 deleterious(0.01) benign(0.36) - Lectin_C 11:66084140 11:66316669 60 3.01
link to download the report for this variant 120 120 PRO LEU 5AO5_A MODEL Neutral none predicted - - - rs1311518287 ENST00000311330 deleterious(0.01) benign(0.36) - Lectin_C 11:66084140 11:66316669 60 3.01
link to download the report for this variant 121 121 ALA SER 5AO5_A MODEL Neutral none predicted - - 4.345e-06 rs772500648 ENST00000311330 tolerated(0.16) probably_damaging(0.917) - Lectin_C 11:66084138 11:66316667 60 3.96
link to download the report for this variant 121 121 ALA PRO 5AO5_A MODEL Damaging Disallowed phi/psi - - 4.345e-06 rs772500648 ENST00000311330 tolerated(0.16) probably_damaging(0.917) - Lectin_C 11:66084138 11:66316667 60 3.96
link to download the report for this variant 123 123 GLY ARG 5AO5_A MODEL Neutral none predicted - - - rs1384714069 ENST00000311330 tolerated(0.56) benign(0.276) - Lectin_C 11:66084132 11:66316661 51 1.41
link to download the report for this variant 123 123 GLY GLU 5AO5_A MODEL Neutral none predicted - - - rs1296306817 ENST00000311330 tolerated(1) benign(0.007) - Lectin_C 11:66084131 11:66316660 51 0.5
link to download the report for this variant 125 125 PRO SER 5AO5_A MODEL Neutral none predicted - - 4.36e-06 rs151292327 ENST00000311330 tolerated(0.53) benign(0.012) - Lectin_C 11:66084126 11:66316655 51 0.7
link to download the report for this variant 125 125 PRO LEU 5AO5_A MODEL Neutral none predicted - - 1.307e-05 rs376672032 ENST00000311330 deleterious(0.02) benign(0.138) - Lectin_C 11:66084125 11:66316654 0 3.96
link to download the report for this variant 127 127 PRO LEU 3KQG_B MODEL Damaging Secondary structure altered - - - rs955375139 ENST00000311330 tolerated(0.19) benign(0.092) - Lectin_C 11:66084119 11:66316648 52 3.04
link to download the report for this variant 127 127 PRO SER 3KQG_B MODEL Damaging Secondary structure altered - - - rs1003127429 ENST00000311330 tolerated(1) benign(0.038) - Lectin_C 11:66084120 11:66316649 52 3.01
link to download the report for this variant 130 130 ARG HIS 5AO5_A MODEL Neutral none predicted - - 8.77e-06 rs755921687 ENST00000311330 deleterious(0) probably_damaging(0.989) - Lectin_C 11:66084110 11:66316639 0 3.96
link to download the report for this variant 130 130 ARG LEU 5AO5_A MODEL Neutral none predicted - - 8.77e-06 rs755921687 ENST00000311330 deleterious(0) probably_damaging(0.989) - Lectin_C 11:66084110 11:66316639 0 3.96
link to download the report for this variant 130 130 ARG CYS 5AO5_A MODEL Neutral none predicted - - 4.385e-06 rs779753603 ENST00000311330 deleterious(0) probably_damaging(0.988) - Lectin_C 11:66084111 11:66316640 52 3.96
link to download the report for this variant 130 130 ARG GLY 5AO5_A MODEL Neutral none predicted - - 4.385e-06 rs779753603 ENST00000311330 deleterious(0) probably_damaging(0.988) - Lectin_C 11:66084111 11:66316640 52 3.96
link to download the report for this variant 131 131 CYS ARG 5AO5_A MODEL Neutral none predicted - - 4.383e-06 rs767570725 ENST00000311330 deleterious(0) probably_damaging(0.999) - Lectin_C 11:66084108 11:66316637 63 3.96
link to download the report for this variant 133 133 ALA VAL 5AO5_A MODEL Neutral none predicted - - 0.0 rs1180582587 ENST00000311330 tolerated(0.47) possibly_damaging(0.872) - Lectin_C 11:66084101 11:66316630 63 4.1
link to download the report for this variant 135 135 GLU LYS 5AO5_A MODEL Neutral none predicted - - 8.794e-06 rs757222983 ENST00000311330 tolerated(0.15) probably_damaging(0.963) - Lectin_C 11:66084096 11:66316625 63 3.96
link to download the report for this variant 136 136 ALA GLY 5AO5_A MODEL Neutral none predicted - - 4.409e-06 rs752848894 ENST00000311330 tolerated(0.23) benign(0.202) - Lectin_C 11:66084092 11:66316621 9 3.96
link to download the report for this variant 137 137 SER ASN 5AO5_A MODEL Neutral none predicted - - 0.0 rs1216216283 ENST00000311330 tolerated(0.15) benign(0) - Lectin_C 11:66084089 11:66316618 31 0.64
link to download the report for this variant 139 139 GLU LYS 5AO5_A MODEL Neutral none predicted - - 1.325e-05 rs371429917 ENST00000311330 tolerated(0.17) benign(0.138) - Lectin_C 11:66084084 11:66316613 31 2.14
link to download the report for this variant 141 141 ARG CYS 5AO5_A MODEL Neutral none predicted - - 4.42e-06 rs759655028 ENST00000311330 deleterious(0) probably_damaging(0.947) - Lectin_C 11:66084078 11:66316607 19 3.11
link to download the report for this variant 144 144 GLU GLY 5AO5_A MODEL Neutral none predicted - - - rs1384149607 ENST00000311330 deleterious(0.01) benign(0.285) - Lectin_C 11:66084068 11:66316597 0 4.06
link to download the report for this variant 144 144 GLU GLN 5AO5_A MODEL Neutral none predicted - - 4.417e-06 rs1289095287 ENST00000311330 deleterious(0.01) probably_damaging(0.958) - Lectin_C 11:66084069 11:66316598 36 4.06
link to download the report for this variant 146 146 SER TRP 5AO5_A MODEL Neutral none predicted - - 4.428e-06 rs892922589 ENST00000311330 deleterious(0) probably_damaging(0.996) - Lectin_C 11:66084062 11:66316591 26 4.06
link to download the report for this variant 146 146 SER LEU 5AO5_A MODEL Neutral none predicted - - 4.428e-06 rs892922589 ENST00000311330 deleterious(0) probably_damaging(0.996) - Lectin_C 11:66084062 11:66316591 26 4.06
link to download the report for this variant 148 148 THR MET 5AO5_A MODEL Neutral none predicted - - 4.427e-06 rs142403837 ENST00000311330 deleterious(0) possibly_damaging(0.652) - Lectin_C 11:66084056 11:66316585 19 4.06
link to download the report for this variant 148 148 THR LYS 5AO5_A MODEL Neutral none predicted - - 4.427e-06 rs142403837 ENST00000311330 deleterious(0) possibly_damaging(0.652) - Lectin_C 11:66084056 11:66316585 19 4.06
link to download the report for this variant 148 148 THR ALA 5AO5_A MODEL Neutral none predicted - - 4.425e-06 rs761031710 ENST00000311330 tolerated(0.1) benign(0.403) - Lectin_C 11:66084057 11:66316586 19 4.1
link to download the report for this variant 149 149 LEU PRO 5AO5_A MODEL Neutral none predicted - - - rs890965251 ENST00000311330 deleterious(0) probably_damaging(0.993) - Lectin_C 11:66084053 11:66316582 47 4.06
link to download the report for this variant 150 150 ALA ASP 5AO5_A MODEL Damaging Buried hydrophilic introduced; Buried charge introduced - - - rs1259403529 ENST00000311330 tolerated(0.05) possibly_damaging(0.624) - Lectin_C 11:66084050 11:66316579 47 4.06
link to download the report for this variant 152 152 ASP ASN 5AO5_A MODEL Neutral none predicted - - 4.452e-06 rs554499998 ENST00000311330 deleterious(0) probably_damaging(0.996) - Lectin_C 11:66084045 11:66316574 47 4.06
link to download the report for this variant 153 153 GLY SER 5AO5_A MODEL Damaging Buried Gly replaced - - 4.453e-06 rs1407547395 ENST00000311330 deleterious(0) probably_damaging(1) - Lectin_C 11:66084042 11:66316571 3 4.06
link to download the report for this variant 154 154 TYR HIS 5AO5_A MODEL Damaging Buried charge introduced - - 8.92e-06 rs768119917 ENST00000311330 deleterious(0) probably_damaging(0.992) - Lectin_C 11:66084039 11:66316568 3 3.88
link to download the report for this variant 159 159 GLY SER 5AO5_A MODEL Neutral none predicted - - 0.0 rs1193382931 ENST00000311330 tolerated(0.12) benign(0.177) - - 11:66084024 11:66316553 75 4.06
link to download the report for this variant 160 160 PHE LEU 5AO5_A MODEL Neutral none predicted - - 4.469e-06 rs377719515 ENST00000311330 deleterious(0.01) benign(0.125) - - 11:66084019 11:66316548 75 -0.42
link to download the report for this variant 161 161 GLU LYS 5AO5_A MODEL Neutral none predicted - - 2.236e-05 rs1265621425 ENST00000311330 tolerated(0.31) benign(0.05) - - 11:66084018 11:66316547 0 4.06
link to download the report for this variant 162 162 GLY ASP 5AO5_A MODEL Damaging Clash - - - rs1206626988 ENST00000311330 deleterious(0.03) probably_damaging(0.973) - - 11:66084014 11:66316543 47 3.09
link to download the report for this variant 163 163 ALA THR 5AO5_A MODEL Neutral none predicted - - 1.345e-05 rs745693208 ENST00000311330 tolerated(0.15) benign(0.043) - - 11:66084012 11:66316541 47 2.12
link to download the report for this variant 163 163 ALA SER 5AO5_A MODEL Neutral none predicted - - 1.345e-05 rs745693208 ENST00000311330 tolerated(0.15) benign(0.043) - - 11:66084012 11:66316541 47 2.12
link to download the report for this variant 165 165 PRO LEU 5AO5_A MODEL Neutral none predicted - - 3.131e-05 rs146691747 ENST00000311330 tolerated(0.06) probably_damaging(0.98) - - 11:66084005 11:66316534 47 3.97
link to download the report for this variant 165 165 PRO ARG 5AO5_A MODEL Neutral none predicted - - 3.131e-05 rs146691747 ENST00000311330 tolerated(0.06) probably_damaging(0.98) - - 11:66084005 11:66316534 47 3.97
link to download the report for this variant 166 166 ALA VAL 5AO5_A MODEL Neutral none predicted - - 1.793e-05 rs764077687 ENST00000311330 deleterious(0.01) probably_damaging(0.926) - - 11:66084002 11:66316531 3 4.19
link to download the report for this variant 166 166 ALA THR 5AO5_A MODEL Neutral none predicted - - - rs1246987731 ENST00000311330 deleterious(0.01) possibly_damaging(0.888) - - 11:66084003 11:66316532 3 3.27
link to download the report for this variant 167 167 LEU PRO 5AO5_A MODEL Damaging Disallowed phi/psi - - 4.482e-06 rs1279721701 ENST00000311330 deleterious(0) probably_damaging(0.988) - - 11:66083999 11:66316528 3 4.1
link to download the report for this variant 168 168 GLN PRO 5AO5_A MODEL Damaging Clash; Disallowed phi/psi - - 4.472e-06 rs909334458 ENST00000311330 tolerated(0.97) benign(0) - - 11:66083996 11:66316525 3 0.19
link to download the report for this variant 169 169 ASP VAL 5AO5_A MODEL Neutral none predicted - - 4.471e-06 rs368665958 ENST00000311330 tolerated(0.3) benign(0) - - 11:66083993 11:66316522 3 -2.11
link to download the report for this variant 169 169 ASP GLY 5AO5_A MODEL Neutral none predicted - - 4.471e-06 rs368665958 ENST00000311330 tolerated(0.3) benign(0) - - 11:66083993 11:66316522 3 -2.11
link to download the report for this variant 202 202 GLN PRO 6B0H_J MODEL Neutral none predicted - - 0.0002 rs547272895 ENST00000311330 tolerated(1) benign(0) - - 11:66083894 11:66316423 36 0.61
link to download the report for this variant 203 203 CYS ARG 6B0H_J MODEL Neutral none predicted - - 4.332e-06 rs1379743405 ENST00000311330 deleterious(0) probably_damaging(0.997) - - 11:66083892 11:66316421 36 4.17
link to download the report for this variant 204 204 GLN LEU 6B0H_J MODEL Neutral none predicted - - 4.311e-06 rs1177982397 ENST00000311330 tolerated(0.64) benign(0) - - 11:66083888 11:66316417 26 0.18
link to download the report for this variant 204 204 GLN ARG 6B0H_J MODEL Neutral none predicted - - 4.311e-06 rs1177982397 ENST00000311330 tolerated(0.64) benign(0) - - 11:66083888 11:66316417 26 0.18
link to download the report for this variant 205 205 ALA VAL 6B0H_J MODEL Neutral none predicted - - 3.018e-05 rs534962077 ENST00000311330 tolerated(0.14) benign(0.001) - - 11:66083885 11:66316414 26 0.52
link to download the report for this variant 205 205 ALA THR 6B0H_J MODEL Neutral none predicted - - 4.31e-06 rs1437745483 ENST00000311330 tolerated(0.39) benign(0.007) - - 11:66083886 11:66316415 26 2.22
link to download the report for this variant 207 207 ARG LYS 6B0H_J MODEL Neutral none predicted - - 4.717e-05 rs775842730 ENST00000311330 tolerated(0.58) benign(0.003) - - 11:66083879 11:66316408 19 4.17
link to download the report for this variant 208 208 GLY GLU 6B0H_J MODEL Neutral none predicted - - 4.278e-06 rs769473334 ENST00000311330 tolerated(1) benign(0) - - 11:66083876 11:66316405 4 2.11
link to download the report for this variant 208 208 GLY ALA 6B0H_J MODEL Neutral none predicted - - 4.278e-06 rs769473334 ENST00000311330 tolerated(1) benign(0) - - 11:66083876 11:66316405 4 2.11
link to download the report for this variant 209 209 ALA VAL 6B0H_J MODEL Neutral none predicted - - 4.273e-06 rs759099892 ENST00000311330 tolerated(0.24) benign(0.022) - - 11:66083873 11:66316402 4 4.17
link to download the report for this variant 211 211 LEU PRO 6B0H_J MODEL Damaging Disallowed phi/psi - - 4.24e-06 rs1348032924 ENST00000311330 deleterious(0.01) possibly_damaging(0.88) - - 11:66083867 11:66316396 60 4.17
link to download the report for this variant 214 214 VAL MET 6B0H_J MODEL Damaging Cavity altered - - 3.375e-05 rs770638919 ENST00000311330 tolerated(0.91) benign(0.003) - - 11:66083859 11:66316388 60 1.51
link to download the report for this variant 214 214 VAL ALA 6B0H_J MODEL Neutral none predicted - - - rs1281666942 ENST00000311330 deleterious(0.03) benign(0.027) - - 11:66083858 11:66316387 0 4.17
link to download the report for this variant 217 217 PRO ALA 6B0H_J MODEL Neutral none predicted - - 4.201e-06 rs1379740685 ENST00000311330 tolerated(0.13) possibly_damaging(0.452) - - 11:66083850 11:66316379 52 4.17
link to download the report for this variant 217 217 PRO THR 6B0H_J MODEL Neutral none predicted - - 4.201e-06 rs1379740685 ENST00000311330 tolerated(0.13) possibly_damaging(0.452) - - 11:66083850 11:66316379 52 4.17
link to download the report for this variant 222 222 GLY SER 6B0H_J MODEL Neutral none predicted - - 4.164e-06 rs370925446 ENST00000311330 tolerated(0.07) benign(0.094) - - 11:66083835 11:66316364 14 2.26
link to download the report for this variant 222 222 GLY ARG 6B0H_J MODEL Neutral none predicted - - 4.164e-06 rs370925446 ENST00000311330 tolerated(0.07) benign(0.094) - - 11:66083835 11:66316364 14 2.26
link to download the report for this variant 225 225 ARG GLN 6B0H_J MODEL Neutral none predicted - - 1.245e-05 rs565157270 ENST00000311330 tolerated(0.57) benign(0.007) - - 11:66083825 11:66316354 20 3.07
link to download the report for this variant 225 225 ARG TRP 6B0H_J MODEL Damaging Cavity altered - - 8.302e-06 rs1024080268 ENST00000311330 deleterious(0) possibly_damaging(0.635) - - 11:66083826 11:66316355 20 4.17
link to download the report for this variant 226 226 ALA VAL 6B0H_J MODEL Neutral none predicted - - - - - tolerated(0.13) benign(0.027) - - - - - -
link to download the report for this variant 226 226 ALA ASP 6B0H_J MODEL Neutral none predicted - - - rs1250846340 ENST00000311330 tolerated(0.63) benign(0.003) - - 11:66083822 11:66316351 37 3.2
link to download the report for this variant 228 228 PRO LEU 6B0H_J MODEL Neutral none predicted - - 0.002074 rs149949198 ENST00000311330 deleterious(0.04) probably_damaging(0.966) - - 11:66083816 11:66316345 37 4.17
link to download the report for this variant 229 229 LEU PRO 6B0H_J MODEL Damaging Disallowed phi/psi - - 0.0 rs1485793713 ENST00000311330 deleterious(0.03) possibly_damaging(0.831) - - 11:66083813 11:66316342 89 4.17
link to download the report for this variant 235 235 CYS TRP 6B0H_J MODEL Neutral none predicted - - 0.0003349 rs764573416 ENST00000311330 deleterious(0) probably_damaging(0.993) - FXa_inhibition 11:66083794 11:66316323 89 -2.43
link to download the report for this variant 236 236 SER ILE 6B0H_J MODEL Neutral none predicted - - 8.277e-06 rs763200019 ENST00000311330 tolerated(0.05) benign(0.043) - FXa_inhibition 11:66083792 11:66316321 89 1.02
link to download the report for this variant 237 237 PRO THR 6B0H_J MODEL Neutral none predicted - - 4.136e-06 rs753301500 ENST00000311330 tolerated(0.3) benign(0.021) - FXa_inhibition 11:66083790 11:66316319 89 4.17
link to download the report for this variant 238 238 ASP TYR 6B0H_J MODEL Neutral none predicted - - 4.132e-06 rs1339118961 ENST00000311330 deleterious(0) possibly_damaging(0.707) - FXa_inhibition 11:66083787 11:66316316 89 3.25
link to download the report for this variant 239 239 ASN SER 6B0H_J MODEL Neutral none predicted - - 4.123e-06 rs1295495133 ENST00000311330 deleterious(0) possibly_damaging(0.683) - FXa_inhibition 11:66083783 11:66316312 10 4.17
link to download the report for this variant 240 240 GLY ARG 6B0H_J MODEL Neutral none predicted - - 2.057e-05 rs759120014 ENST00000311330 deleterious(0) possibly_damaging(0.678) - FXa_inhibition 11:66083781 11:66316310 1 4.17
link to download the report for this variant 240 240 GLY GLU 6B0H_J MODEL Neutral none predicted - - 4.114e-06 rs1296504209 ENST00000311330 deleterious(0) possibly_damaging(0.539) - FXa_inhibition 11:66083780 11:66316309 0 4.17
link to download the report for this variant 241 241 GLY CYS 6B0H_J MODEL Damaging Disallowed phi/psi - - - rs1443994193 ENST00000311330 deleterious(0.01) probably_damaging(0.998) - FXa_inhibition 11:66083778 11:66316307 38 4.17
link to download the report for this variant 241 241 GLY ASP 6B0H_J MODEL Damaging Disallowed phi/psi - - 0.0 rs1036312692 ENST00000311330 deleterious(0) probably_damaging(0.993) - FXa_inhibition 11:66083777 11:66316306 38 4.17
link to download the report for this variant 243 243 GLU GLN 6B0H_J MODEL Neutral none predicted - - 4.116e-06 rs1366572111 ENST00000311330 tolerated(0.2) probably_damaging(0.97) - FXa_inhibition 11:66083772 11:66316301 38 4.17
link to download the report for this variant 245 245 GLU LYS 6B0H_J MODEL Neutral none predicted - - 0.0 rs991947564 ENST00000311330 tolerated(0.32) benign(0.365) - FXa_inhibition 11:66083766 11:66316295 73 4.17
link to download the report for this variant 249 249 GLU ASP 6B0H_J MODEL Neutral none predicted - - 0.0 rs1448247846 ENST00000311330 tolerated(0.25) benign(0.001) - FXa_inhibition 11:66083752 11:66316281 0 1.16
link to download the report for this variant 249 249 GLU GLY 6B0H_J MODEL Neutral none predicted - - 4.104e-06 rs1191009162 ENST00000311330 tolerated(0.12) benign(0.039) - FXa_inhibition 11:66083753 11:66316282 73 1.71
link to download the report for this variant 251 251 ASP ASN 6B0H_J MODEL Neutral none predicted - - - - - tolerated(0.37) benign(0.003) - FXa_inhibition - - - -
link to download the report for this variant 251 251 ASP TYR 6B0H_J MODEL Neutral none predicted - - - - - deleterious(0.01) possibly_damaging(0.635) - FXa_inhibition - - - -
link to download the report for this variant 252 252 GLY VAL 6B0H_J MODEL Damaging Disallowed phi/psi; Gly in a bend - - 4.103e-06 rs1209835925 ENST00000311330 deleterious(0) possibly_damaging(0.527) - FXa_inhibition 11:66083744 11:66316273 20 4.17
link to download the report for this variant 253 253 HIS ASN 6B0H_J MODEL Neutral none predicted - - 6.154e-05 rs543288231 ENST00000311330 tolerated(0.15) benign(0.015) - FXa_inhibition 11:66083742 11:66316271 1 2.09
link to download the report for this variant 254 254 VAL MET 6B0H_J MODEL Neutral none predicted - - 0.0002545 rs202021533 ENST00000311330 tolerated(0.09) benign(0.037) - FXa_inhibition 11:66083739 11:66316268 4 2.16
link to download the report for this variant 254 254 VAL ALA 6B0H_J MODEL Neutral none predicted - - 4.103e-06 rs774286084 ENST00000311330 tolerated(0.14) benign(0.015) - FXa_inhibition 11:66083738 11:66316267 0 2.99
link to download the report for this variant 255 255 SER PHE 6B0H_J MODEL Neutral none predicted - - 4.101e-06 rs1433122967 ENST00000311330 tolerated(0.2) benign(0.028) - FXa_inhibition 11:66083735 11:66316264 4 4.17
link to download the report for this variant 257 257 ARG HIS 6B0H_J MODEL Neutral none predicted - - - - - tolerated(0.2) benign(0.003) - FXa_inhibition - - - -
link to download the report for this variant 259 259 THR SER 6B0H_J MODEL Neutral none predicted - - 4.097e-06 rs150759404 ENST00000311330 tolerated(1) benign(0) - FXa_inhibition 11:66083723 11:66316252 20 1.03
link to download the report for this variant 261 261 GLY SER 6B0H_J MODEL Neutral none predicted - - 4.097e-06 rs1388509192 ENST00000311330 deleterious(0) probably_damaging(0.998) - FXa_inhibition 11:66083718 11:66316247 14 4.08
link to download the report for this variant 263 263 ARG GLN 6B0H_J MODEL Neutral none predicted - - 1.64e-05 rs777857099 ENST00000311330 tolerated(0.64) benign(0.001) - FXa_inhibition 11:66083711 11:66316240 0 2.19
link to download the report for this variant 263 263 ARG LEU 6B0H_J MODEL Neutral none predicted - - 1.64e-05 rs777857099 ENST00000311330 tolerated(0.64) benign(0.001) - FXa_inhibition 11:66083711 11:66316240 0 2.19
link to download the report for this variant 263 263 ARG TRP 6B0H_J MODEL Neutral none predicted - - 7.38e-05 rs747299781 ENST00000311330 tolerated(0.11) possibly_damaging(0.451) - FXa_inhibition 11:66083712 11:66316241 20 3.1
link to download the report for this variant 264 264 LEU VAL 6B0H_J MODEL Neutral none predicted - - 4.101e-06 rs758800666 ENST00000311330 tolerated(0.06) possibly_damaging(0.513) - FXa_inhibition 11:66083709 11:66316238 1 3.16
link to download the report for this variant 266 266 ALA VAL 6B0H_J MODEL Neutral none predicted - - 4.105e-06 rs765874072 ENST00000311330 tolerated(0.19) benign(0) - FXa_inhibition 11:66083702 11:66316231 27 -0.49
link to download the report for this variant 267 267 ASP TYR 6B0H_J MODEL Neutral none predicted - - - - - deleterious(0) probably_damaging(0.995) - FXa_inhibition - - - -
link to download the report for this variant 268 268 GLY ARG 6B0H_J MODEL Damaging Disallowed phi/psi - - - - - deleterious(0.02) probably_damaging(0.995) - FXa_inhibition - - - -
link to download the report for this variant 269 269 ARG HIS 6B0H_J MODEL Neutral none predicted - - 3.289e-05 rs138870896 ENST00000311330 tolerated(0.67) benign(0) - FXa_inhibition 11:66083693 11:66316222 0 -3.66
link to download the report for this variant 269 269 ARG CYS 6B0H_J MODEL Neutral none predicted - - 1.645e-05 rs760099179 ENST00000311330 deleterious(0) benign(0.109) - FXa_inhibition 11:66083694 11:66316223 4 4.08
link to download the report for this variant 270 270 SER ASN 6B0H_J MODEL Neutral none predicted - - - rs767021528 ENST00000311330 tolerated(0.08) benign(0.043) - FXa_inhibition 11:66083690 11:66316219 4 4.08
link to download the report for this variant 270 270 SER THR 6B0H_J MODEL Neutral none predicted - - - rs767021528 ENST00000311330 tolerated(0.08) benign(0.043) - FXa_inhibition 11:66083690 11:66316219 4 4.08
link to download the report for this variant 272 272 GLU GLN 6B0H_J MODEL Damaging Buried charge replaced - - 1.235e-05 rs768605522 ENST00000311330 deleterious(0.02) benign(0.036) - - 11:66083685 11:66316214 14 3.12
link to download the report for this variant 272 272 GLU LYS 6B0H_J MODEL Damaging Buried / exposed switch - - 1.235e-05 rs768605522 ENST00000311330 deleterious(0.02) benign(0.036) - - 11:66083685 11:66316214 14 3.12
link to download the report for this variant 273 273 ASP VAL 6B0H_J MODEL Neutral none predicted - - 4.12e-06 rs1017953810 ENST00000311330 deleterious(0) probably_damaging(0.996) - - 11:66083681 11:66316210 10 4.08
link to download the report for this variant 273 273 ASP GLU 6B0H_J MODEL Neutral none predicted - - 4.116e-06 rs1231171921 ENST00000311330 deleterious(0.02) probably_damaging(0.981) - - 11:66083680 11:66316209 0 -0.13
link to download the report for this variant 274 274 PRO LEU 6B0H_J MODEL Neutral none predicted - - 0.000457 rs200973487 ENST00000311330 tolerated(0.07) benign(0.103) - - 11:66083678 11:66316207 0 4.08
link to download the report for this variant 274 274 PRO SER 6B0H_J MODEL Neutral none predicted - - 4.116e-06 rs749275216 ENST00000311330 tolerated(0.17) possibly_damaging(0.614) - - 11:66083679 11:66316208 0 4.08
link to download the report for this variant 276 276 ALA SER 6B0H_J MODEL Neutral none predicted - - 4.119e-06 rs1441518362 ENST00000311330 tolerated(0.44) benign(0.027) - - 11:66083673 11:66316202 14 3.25
link to download the report for this variant 276 276 ALA VAL 6B0H_J MODEL Neutral none predicted - - 0.001369 rs147266530 ENST00000311330 tolerated(0.31) benign(0.003) - - 11:66083672 11:66316201 0 3.22
link to download the report for this variant 277 277 GLN HIS 6B0H_J MODEL Neutral none predicted - - 8.247e-06 rs778056814 ENST00000311330 tolerated(0.28) benign(0) - - 11:66083668 11:66316197 0 -4.2
link to download the report for this variant 277 277 GLN PRO 6B0H_J MODEL Neutral none predicted - - 4.126e-06 rs746999750 ENST00000311330 deleterious(0.04) benign(0.062) - - 11:66083669 11:66316198 4 4.17
link to download the report for this variant 278 278 ALA ASP 6B0H_J MODEL Neutral none predicted - - 0.0005818 rs143931022 ENST00000311330 tolerated(0.17) possibly_damaging(0.888) - - 11:66083666 11:66316195 1 4.17
link to download the report for this variant 278 278 ALA VAL 6B0H_J MODEL Neutral none predicted - - 0.0005818 rs143931022 ENST00000311330 tolerated(0.17) possibly_damaging(0.888) - - 11:66083666 11:66316195 1 4.17
link to download the report for this variant 279 279 PRO GLN 6B0H_J MODEL Neutral none predicted - - - - - deleterious(0.01) probably_damaging(0.926) - - - - - -
link to download the report for this variant 279 279 PRO LEU 6B0H_J MODEL Neutral none predicted - - - - - deleterious(0.04) benign(0.028) - - - - - -
link to download the report for this variant 281 281 GLU LYS 6B0H_J MODEL Neutral none predicted - - 4.134e-06 rs1194843951 ENST00000311330 deleterious(0.02) possibly_damaging(0.45) - - 11:66083658 11:66316187 14 4.17
link to download the report for this variant 282 282 GLN LYS 6B0H_J MODEL Neutral none predicted - - 1.239e-05 rs1439623263 ENST00000311330 tolerated(0.36) benign(0.039) - - 11:66083655 11:66316184 4 4.17
link to download the report for this variant 284 284 CYS ARG 6B0H_J MODEL Damaging Disulphide breakage; Buried hydrophilic introduced; Buried charge introduced - - 4.122e-06 rs558286010 ENST00000311330 deleterious(0) probably_damaging(0.956) - - 11:66083649 11:66316178 20 4.17
link to download the report for this variant 286 286 PRO SER 6B0H_J MODEL Neutral none predicted - - 2.064e-05 rs755663502 ENST00000311330 tolerated(0.08) possibly_damaging(0.808) - - 11:66083643 11:66316172 20 4.17
link to download the report for this variant 287 287 GLY VAL 6B0H_J MODEL Neutral none predicted - - - - - tolerated(0.05) probably_damaging(0.946) - - - - - -
link to download the report for this variant 287 287 GLY SER 6B0H_J MODEL Neutral none predicted - - 7.844e-05 rs374192163 ENST00000311330 deleterious(0.02) possibly_damaging(0.894) - - 11:66083640 11:66316169 4 4.17
link to download the report for this variant 288 288 GLY GLU 6B0H_J MODEL Damaging Disallowed phi/psi - - 4.124e-06 rs767231925 ENST00000311330 tolerated(0.09) probably_damaging(0.976) - - 11:66083636 11:66316165 20 4.17
link to download the report for this variant 289 289 PRO SER 6B0H_J MODEL Neutral none predicted - - 8.251e-06 rs1376079245 ENST00000311330 tolerated(0.07) benign(0.003) - - 11:66083634 11:66316163 20 3.25
link to download the report for this variant 289 289 PRO LEU 6B0H_J MODEL Neutral none predicted - - 4.125e-06 rs751193713 ENST00000311330 deleterious(0) benign(0.058) - - 11:66083633 11:66316162 0 4.17
link to download the report for this variant 293 293 SER ASN 6B0H_J MODEL Neutral none predicted - - 8.324e-06 rs369829580 ENST00000311330 tolerated(0.39) benign(0.143) - - 11:66083621 11:66316150 53 3.24
link to download the report for this variant 296 296 CYS ARG 6B0H_J MODEL Damaging Buried hydrophilic introduced; Buried charge introduced - - 8.191e-06 rs775467640 ENST00000311330 deleterious(0) probably_damaging(0.942) - - 11:66083613 11:66316142 32 4.17
link to download the report for this variant 297 297 ARG CYS 6B0H_J MODEL Neutral none predicted - - 2.458e-05 rs200653218 ENST00000311330 tolerated(0.07) possibly_damaging(0.548) - - 11:66083610 11:66316139 4 4.17
link to download the report for this variant 297 297 ARG HIS 6B0H_J MODEL Neutral none predicted - - 2.043e-05 rs760835312 ENST00000311330 tolerated(0.53) benign(0.015) - - 11:66083609 11:66316138 0 3.22
link to download the report for this variant 301 301 ARG TRP 6B0H_J MODEL Neutral none predicted - - 2.041e-05 rs765999247 ENST00000311330 deleterious(0.01) possibly_damaging(0.897) - - 11:66083598 11:66316127 51 4.17
link to download the report for this variant 301 301 ARG GLN 6B0H_J MODEL Neutral none predicted - - 0.0001306 rs138947853 ENST00000311330 tolerated(0.12) benign(0.055) - - 11:66083597 11:66316126 0 4.17
link to download the report for this variant 302 302 PRO LEU 6B0H_J MODEL Damaging Clash - - 8.157e-06 rs748420625 ENST00000311330 tolerated(1) benign(0.333) - - 11:66083594 11:66316123 7 4.17
link to download the report for this variant 303 303 ALA THR 6B0H_J MODEL Neutral none predicted - - 4.078e-06 rs779271510 ENST00000311330 tolerated(0.13) possibly_damaging(0.698) - - 11:66083592 11:66316121 2 4.17
link to download the report for this variant 303 303 ALA VAL 6B0H_J MODEL Neutral none predicted - - 0.006552 rs150281243 ENST00000311330 tolerated(0.4) benign(0.125) - - 11:66083591 11:66316120 0 3.25
link to download the report for this variant 304 304 GLU LYS 6B0H_J MODEL Neutral none predicted - - 4.077e-06 rs780617204 ENST00000311330 deleterious(0.02) possibly_damaging(0.47) - - 11:66083589 11:66316118 2 4.17
link to download the report for this variant 305 305 ASP TYR 6B0H_J MODEL Neutral none predicted - - - - - deleterious(0) possibly_damaging(0.819) - - - - - -
link to download the report for this variant 306 306 ASP ASN 6B0H_J MODEL Neutral none predicted - - 2.037e-05 rs756539493 ENST00000311330 tolerated(0.21) benign(0.224) - - 11:66083583 11:66316112 24 4.41
link to download the report for this variant 306 306 ASP GLY 6B0H_J MODEL Neutral none predicted - - 4.074e-06 rs749972995 ENST00000311330 tolerated(0.26) benign(0.007) - - 11:66083582 11:66316111 0 4.41
link to download the report for this variant 307 307 PRO LEU 6B0H_J MODEL Neutral none predicted - - 6.926e-05 rs780618986 ENST00000311330 tolerated(0.06) benign(0.327) - - 11:66083579 11:66316108 7 4.41
link to download the report for this variant 309 309 ARG LEU 6B0H_J MODEL Neutral none predicted - - 1.629e-05 rs191098817 ENST00000311330 tolerated(0.08) benign(0.013) - - 11:66083573 11:66316102 0 3.49
link to download the report for this variant 309 309 ARG HIS 6B0H_J MODEL Neutral none predicted - - 1.629e-05 rs191098817 ENST00000311330 tolerated(0.08) benign(0.013) - - 11:66083573 11:66316102 0 3.49
link to download the report for this variant 309 309 ARG CYS 6B0H_J MODEL Neutral none predicted - - 1.222e-05 rs763727746 ENST00000311330 deleterious(0) possibly_damaging(0.762) - - 11:66083574 11:66316103 17 4.41
link to download the report for this variant 311 311 VAL MET 6B0H_J MODEL Neutral none predicted - - 8.142e-06 rs372966232 ENST00000311330 deleterious(0.04) benign(0.421) - - 11:66083568 11:66316097 17 3.45
link to download the report for this variant 312 312 ASP GLY 6B0H_J MODEL Damaging Buried charge replaced; Buried H-bond breakage; Buried salt bridge breakage - - 4.07e-06 rs1313040302 ENST00000311330 deleterious(0) probably_damaging(0.994) - - 11:66083564 11:66316093 0 4.41
link to download the report for this variant 314 314 ASP ASN 6B0H_J MODEL Neutral none predicted - - - - - tolerated(0.09) probably_damaging(0.994) - - - - - -
link to download the report for this variant 317 317 GLN HIS 6B0H_J MODEL Neutral none predicted - - - - - deleterious(0.01) possibly_damaging(0.89) - - - - - -
link to download the report for this variant 320 320 GLY SER 6B0H_J MODEL Neutral none predicted - - 1.627e-05 rs772343825 ENST00000311330 deleterious(0.04) probably_damaging(0.971) - - 11:66083541 11:66316070 83 4.41
link to download the report for this variant 330 330 VAL ALA 6B0H_J MODEL Neutral none predicted - - 4.066e-06 rs1476352928 ENST00000311330 tolerated(0.31) benign(0.012) - - 11:66083510 11:66316039 0 3.28
link to download the report for this variant 330 330 VAL ILE 6B0H_J MODEL Neutral none predicted - - 0.0002155 rs199986876 ENST00000311330 tolerated(0.36) benign(0.007) - - 11:66083511 11:66316040 90 1.41
link to download the report for this variant 331 331 GLY ASP 6B0H_J MODEL Neutral none predicted - - 4.067e-06 rs749702408 ENST00000311330 deleterious(0) probably_damaging(1) - - 11:66083507 11:66316036 7 4.41
link to download the report for this variant 334 334 GLU LYS 6B0H_J MODEL Damaging Buried / exposed switch - - - rs1348222117 ENST00000311330 deleterious(0) probably_damaging(0.965) - - 11:66083499 11:66316028 82 4.56
link to download the report for this variant 339 339 GLU LYS 6B0H_J MODEL Neutral none predicted - - 4.067e-06 rs368068385 ENST00000311330 deleterious(0.01) probably_damaging(0.993) - - 11:66083484 11:66316013 82 4.65
link to download the report for this variant 339 339 GLU GLY 6B0H_J MODEL Neutral none predicted - - 4.068e-06 rs1217943800 ENST00000311330 deleterious(0.01) probably_damaging(0.986) - - 11:66083483 11:66316012 82 4.65
link to download the report for this variant 341 341 HIS GLN 6B0H_J MODEL Neutral none predicted - - 4.069e-06 rs547161139 ENST00000311330 deleterious(0.02) possibly_damaging(0.767) - - 11:66083476 11:66316005 30 -3.6
link to download the report for this variant 344 344 GLU ASP 3M0C_C MODEL Neutral none predicted - - - - - tolerated(0.27) benign(0.045) - - - - - -
link to download the report for this variant 346 346 ASP HIS 3M0C_C MODEL Neutral none predicted - - - - - deleterious(0) probably_damaging(1) - - - - - -
link to download the report for this variant 349 349 SER ARG 3M0C_C MODEL Neutral none predicted - - - rs1485717691 ENST00000311330 deleterious(0) benign(0.357) - - 11:66083452 11:66315981 93 1.67
link to download the report for this variant 353 353 ALA THR 3M0C_C MODEL Neutral none predicted - - - - - tolerated_low_confidence(0.27) benign(0.005) - - - - - -
link to download the report for this variant 353 353 ALA VAL 3M0C_C MODEL Neutral none predicted - - 4.074e-06 rs1336628021 ENST00000311330 tolerated(0.47) benign(0.014) - - 11:66083441 11:66315970 93 1.68
link to download the report for this variant 354 354 GLY GLU 3M0C_C MODEL Neutral none predicted - - 1.222e-05 rs751016786 ENST00000311330 deleterious(0) possibly_damaging(0.813) - - 11:66083438 11:66315967 7 4.65
link to download the report for this variant 355 355 ALA SER 3M0C_C MODEL Neutral none predicted - - - rs1189145994 ENST00000311330 tolerated(0.06) benign(0.3) - - 11:66083436 11:66315965 30 3.71


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version 1.5.4 22/11/22