Documentation

Missense3DTM is prediction software which produces predictions regarding the structural impact of missense variants on transmembrane protein structure. Missense3DTM provides an overall binary prediction as structurally ‘Damaging’ or ‘Neutral’ based on 21 structural features like ‘breakage of a salt bridge’ and ‘cavity altered’. The salient feature of the software is that it works equally well on experimental structures and modelled structures.