Missense3D-TM produces predictions regarding the structural impact of missense variants on transmembrane protein structure. Missense3D-TM provides an overall binary prediction as structurally ‘Damaging’ or ‘Neutral’ based on structural features like ‘breakage of a salt bridge’ and ‘cavity altered’.
Missense3D-PTMdb is a comprehensive resource which allows users to explore millions of variants, post-translational modifications (PTMs), and topology information, if any, for the collection of canonical proteins within the human proteome (~20,000). Users can visualize these features on a 3D AlphaFold model for their protein of interest.
Missense3D-αDB is a database of pre-computed Missense3D predictions of naturally-occurring missense variants evaluated on AlphaFold models across the human proteome.
Missense3D-PPI predicts the structural changes introduced by an amino acid substitution affecting Protein-Protein interfaces. Use this option if your protein structure has multiple chains and the mutation may occur across the interface. It is applicable for the analyse both experimental coordinates and predicted structures.
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