Missense3D Portal
Welcome to the Missense3D suite of resources, developed by Professor Michael Sternberg's Group and Dr Alessia David's Group. The Missense3D portal hosts resources developed to characterise and prioritise missense variants using protein 3D structure information.
Predicts structural changes from amino‑acid substitutions across structures, complexes, and AlphaFold models.
Predicts structural disruption of missense variants in transmembrane proteins.
Contains ~4 million precomputed structural predictions for human missense variants.
Enables exploration of millions of variants, PTMs, and AlphaFold visualisations.
Contains Missense3D predictions for naturally occurring variants evaluated on AlphaFold models across the human proteome.
Predicts protein 3D structure using templates from the PDB and AlphaFold.
Checks whether a protein structure sequence is consistent with the current UniProt entry.
Provides modelled and experimental structures of proteins and complexes annotated with mutation effects.
Missense3D (Legacy): Classic implementation for analysing structural impact of missense variants.
Missense3D-PPI (Legacy): Predicts variant effects at protein–protein interfaces.
